HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens
YOUNG, R. P. ; DEKKER, J. W. ; WORDSWORTH, B. P. ; SCHOU, C. ; PILE, K. D. ; MATTHIESEN, F. ; ROSENBERG, W. M. C. ; BELL, J. I. ; HOPKIN, J. M. ; COOKSON, W. O. C. M.
Oxford, UK : Blackwell Publishing Ltd
Published 1994
Oxford, UK : Blackwell Publishing Ltd
Published 1994
| ISSN: |
1365-2222
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|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
Abstract. In order to test for human histocompatibility leucocyte antigens (HLA) class II restriction of IgE responses, 431 subjects from 83 families were genotyped at the HLA-DR and HLA-DP loci and serotyped for IgE responses to six major allergens from common aero-allergen sources. A possible excess of HLA-DR 1 was found in subjects who were responsive to FeldI compared with those who were not (Odds Ratio (OR) = 2, P = 0.002), and a possible excess of HLA-DR4 was found in subjects responsive to Alt a I (OR = 1–9, P = 0.006). Increased sharing of HLA-DR/DP haplotypes was seen in sibling pairs responding to both allergens. Der p I, Der p II, Phi p V and Can f I were not associated with any definite excess of HLA-DR alleles. No significant correlations were seen with HLA-DP genotype and reactivity to any of the allergens. The results suggest class II HLA restriction is insufficient to account for individual differences in reactivity to common allergens.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798290193350918144 |
|---|---|
| autor | YOUNG, R. P. DEKKER, J. W. WORDSWORTH, B. P. SCHOU, C. PILE, K. D. MATTHIESEN, F. ROSENBERG, W. M. C. BELL, J. I. HOPKIN, J. M. COOKSON, W. O. C. M. |
| autorsonst | YOUNG, R. P. DEKKER, J. W. WORDSWORTH, B. P. SCHOU, C. PILE, K. D. MATTHIESEN, F. ROSENBERG, W. M. C. BELL, J. I. HOPKIN, J. M. COOKSON, W. O. C. M. |
| book_url | http://dx.doi.org/10.1111/j.1365-2222.1994.tb00931.x |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLZ238653897 |
| insertion_date | 2012-04-17 |
| issn | 1365-2222 |
| journal_name | Clinical & experimental allergy |
| materialart | 1 |
| notes | Abstract. In order to test for human histocompatibility leucocyte antigens (HLA) class II restriction of IgE responses, 431 subjects from 83 families were genotyped at the HLA-DR and HLA-DP loci and serotyped for IgE responses to six major allergens from common aero-allergen sources. A possible excess of HLA-DR 1 was found in subjects who were responsive to FeldI compared with those who were not (Odds Ratio (OR) = 2, P = 0.002), and a possible excess of HLA-DR4 was found in subjects responsive to Alt a I (OR = 1–9, P = 0.006). Increased sharing of HLA-DR/DP haplotypes was seen in sibling pairs responding to both allergens. Der p I, Der p II, Phi p V and Can f I were not associated with any definite excess of HLA-DR alleles. No significant correlations were seen with HLA-DP genotype and reactivity to any of the allergens. The results suggest class II HLA restriction is insufficient to account for individual differences in reactivity to common allergens. |
| package_name | Blackwell Publishing |
| publikationsjahr_anzeige | 1994 |
| publikationsjahr_facette | 1994 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1994 |
| publikationsort | Oxford, UK |
| publisher | Blackwell Publishing Ltd |
| reference | 24 (1994), S. 0 |
| search_space | articles |
| shingle_author_1 | YOUNG, R. P. DEKKER, J. W. WORDSWORTH, B. P. SCHOU, C. PILE, K. D. MATTHIESEN, F. ROSENBERG, W. M. C. BELL, J. I. HOPKIN, J. M. COOKSON, W. O. C. M. |
| shingle_author_2 | YOUNG, R. P. DEKKER, J. W. WORDSWORTH, B. P. SCHOU, C. PILE, K. D. MATTHIESEN, F. ROSENBERG, W. M. C. BELL, J. I. HOPKIN, J. M. COOKSON, W. O. C. M. |
| shingle_author_3 | YOUNG, R. P. DEKKER, J. W. WORDSWORTH, B. P. SCHOU, C. PILE, K. D. MATTHIESEN, F. ROSENBERG, W. M. C. BELL, J. I. HOPKIN, J. M. COOKSON, W. O. C. M. |
| shingle_author_4 | YOUNG, R. P. DEKKER, J. W. WORDSWORTH, B. P. SCHOU, C. PILE, K. D. MATTHIESEN, F. ROSENBERG, W. M. C. BELL, J. I. HOPKIN, J. M. COOKSON, W. O. C. M. |
| shingle_catch_all_1 | YOUNG, R. P. DEKKER, J. W. WORDSWORTH, B. P. SCHOU, C. PILE, K. D. MATTHIESEN, F. ROSENBERG, W. M. C. BELL, J. I. HOPKIN, J. M. COOKSON, W. O. C. M. HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens Blackwell Publishing Ltd Abstract. In order to test for human histocompatibility leucocyte antigens (HLA) class II restriction of IgE responses, 431 subjects from 83 families were genotyped at the HLA-DR and HLA-DP loci and serotyped for IgE responses to six major allergens from common aero-allergen sources. A possible excess of HLA-DR 1 was found in subjects who were responsive to FeldI compared with those who were not (Odds Ratio (OR) = 2, P = 0.002), and a possible excess of HLA-DR4 was found in subjects responsive to Alt a I (OR = 1–9, P = 0.006). Increased sharing of HLA-DR/DP haplotypes was seen in sibling pairs responding to both allergens. Der p I, Der p II, Phi p V and Can f I were not associated with any definite excess of HLA-DR alleles. No significant correlations were seen with HLA-DP genotype and reactivity to any of the allergens. The results suggest class II HLA restriction is insufficient to account for individual differences in reactivity to common allergens. 1365-2222 13652222 |
| shingle_catch_all_2 | YOUNG, R. P. DEKKER, J. W. WORDSWORTH, B. P. SCHOU, C. PILE, K. D. MATTHIESEN, F. ROSENBERG, W. M. C. BELL, J. I. HOPKIN, J. M. COOKSON, W. O. C. M. HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens Blackwell Publishing Ltd Abstract. In order to test for human histocompatibility leucocyte antigens (HLA) class II restriction of IgE responses, 431 subjects from 83 families were genotyped at the HLA-DR and HLA-DP loci and serotyped for IgE responses to six major allergens from common aero-allergen sources. A possible excess of HLA-DR 1 was found in subjects who were responsive to FeldI compared with those who were not (Odds Ratio (OR) = 2, P = 0.002), and a possible excess of HLA-DR4 was found in subjects responsive to Alt a I (OR = 1–9, P = 0.006). Increased sharing of HLA-DR/DP haplotypes was seen in sibling pairs responding to both allergens. Der p I, Der p II, Phi p V and Can f I were not associated with any definite excess of HLA-DR alleles. No significant correlations were seen with HLA-DP genotype and reactivity to any of the allergens. The results suggest class II HLA restriction is insufficient to account for individual differences in reactivity to common allergens. 1365-2222 13652222 |
| shingle_catch_all_3 | YOUNG, R. P. DEKKER, J. W. WORDSWORTH, B. P. SCHOU, C. PILE, K. D. MATTHIESEN, F. ROSENBERG, W. M. C. BELL, J. I. HOPKIN, J. M. COOKSON, W. O. C. M. HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens Blackwell Publishing Ltd Abstract. In order to test for human histocompatibility leucocyte antigens (HLA) class II restriction of IgE responses, 431 subjects from 83 families were genotyped at the HLA-DR and HLA-DP loci and serotyped for IgE responses to six major allergens from common aero-allergen sources. A possible excess of HLA-DR 1 was found in subjects who were responsive to FeldI compared with those who were not (Odds Ratio (OR) = 2, P = 0.002), and a possible excess of HLA-DR4 was found in subjects responsive to Alt a I (OR = 1–9, P = 0.006). Increased sharing of HLA-DR/DP haplotypes was seen in sibling pairs responding to both allergens. Der p I, Der p II, Phi p V and Can f I were not associated with any definite excess of HLA-DR alleles. No significant correlations were seen with HLA-DP genotype and reactivity to any of the allergens. The results suggest class II HLA restriction is insufficient to account for individual differences in reactivity to common allergens. 1365-2222 13652222 |
| shingle_catch_all_4 | YOUNG, R. P. DEKKER, J. W. WORDSWORTH, B. P. SCHOU, C. PILE, K. D. MATTHIESEN, F. ROSENBERG, W. M. C. BELL, J. I. HOPKIN, J. M. COOKSON, W. O. C. M. HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens Blackwell Publishing Ltd Abstract. In order to test for human histocompatibility leucocyte antigens (HLA) class II restriction of IgE responses, 431 subjects from 83 families were genotyped at the HLA-DR and HLA-DP loci and serotyped for IgE responses to six major allergens from common aero-allergen sources. A possible excess of HLA-DR 1 was found in subjects who were responsive to FeldI compared with those who were not (Odds Ratio (OR) = 2, P = 0.002), and a possible excess of HLA-DR4 was found in subjects responsive to Alt a I (OR = 1–9, P = 0.006). Increased sharing of HLA-DR/DP haplotypes was seen in sibling pairs responding to both allergens. Der p I, Der p II, Phi p V and Can f I were not associated with any definite excess of HLA-DR alleles. No significant correlations were seen with HLA-DP genotype and reactivity to any of the allergens. The results suggest class II HLA restriction is insufficient to account for individual differences in reactivity to common allergens. 1365-2222 13652222 |
| shingle_title_1 | HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens |
| shingle_title_2 | HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens |
| shingle_title_3 | HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens |
| shingle_title_4 | HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens |
| sigel_instance_filter | dkfz geomar wilbert ipn albert |
| source_archive | Blackwell Publishing Journal Backfiles 1879-2005 |
| timestamp | 2024-05-06T08:12:50.168Z |
| titel | HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens |
| titel_suche | HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens |
| topic | WW-YZ |
| uid | nat_lic_papers_NLZ238653897 |