HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens
YOUNG, R. P. ; DEKKER, J. W. ; WORDSWORTH, B. P. ; SCHOU, C. ; PILE, K. D. ; MATTHIESEN, F. ; ROSENBERG, W. M. C. ; BELL, J. I. ; HOPKIN, J. M. ; COOKSON, W. O. C. M.
Oxford, UK : Blackwell Publishing Ltd
Published 1994
Oxford, UK : Blackwell Publishing Ltd
Published 1994
| ISSN: |
1365-2222
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| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
Abstract. In order to test for human histocompatibility leucocyte antigens (HLA) class II restriction of IgE responses, 431 subjects from 83 families were genotyped at the HLA-DR and HLA-DP loci and serotyped for IgE responses to six major allergens from common aero-allergen sources. A possible excess of HLA-DR 1 was found in subjects who were responsive to FeldI compared with those who were not (Odds Ratio (OR) = 2, P = 0.002), and a possible excess of HLA-DR4 was found in subjects responsive to Alt a I (OR = 1–9, P = 0.006). Increased sharing of HLA-DR/DP haplotypes was seen in sibling pairs responding to both allergens. Der p I, Der p II, Phi p V and Can f I were not associated with any definite excess of HLA-DR alleles. No significant correlations were seen with HLA-DP genotype and reactivity to any of the allergens. The results suggest class II HLA restriction is insufficient to account for individual differences in reactivity to common allergens.
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| Type of Medium: |
Electronic Resource
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| URL: |