Non–invasive liposome–mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice
Alton, E. W. F. W. ; Middleton, P. G. ; Caplen, N. J. ; Smith, S. N. ; Steel, D. M. ; Munkonge, F. M. ; Jeffery, P. K. ; Geddes, D. M. ; Hart, S. L. ; Williamson, R. ; Fasold, K. I. ; Miller, A. D. ; Dickinson, P. ; Stevenson, B. J. ; McLachlan, G. ; Dorin, J. R. ; Porteous, D. J.
[s.l.] : Nature Publishing Group
Published 1993
[s.l.] : Nature Publishing Group
Published 1993
| ISSN: |
1546-1718
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|---|---|
| Source: |
Nature Archives 1869 - 2009
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| Topics: |
Biology
Medicine
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| Notes: |
[Auszug] We report gene transfer to the Edinburgh insertional mutant mouse (cf/cf), delivering CFTR cDNA–liposome complexes into the airways by nebulization. We show full restoration of cAMP related chloride responses in some animals and demonstrate, in the same tissues, human CFTR cDNA expression. ...
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| Type of Medium: |
Electronic Resource
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| URL: |