G"M"2 Activator Protein Expression in Mouse Tissues
Beccari, T. ; Palmerini, C.A. ; Servillo, G. ; Dellafazia, M.A. ; Magni, M.P.V. ; Orlacchio, A.
Amsterdam : Elsevier
Amsterdam : Elsevier
| ISSN: |
0006-291X
|
|---|---|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
|
| Topics: |
Biology
Chemistry and Pharmacology
Physics
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798292263590166528 |
|---|---|
| autor | Beccari, T. Palmerini, C.A. Servillo, G. Dellafazia, M.A. Magni, M.P.V. Orlacchio, A. |
| autorsonst | Beccari, T. Palmerini, C.A. Servillo, G. Dellafazia, M.A. Magni, M.P.V. Orlacchio, A. |
| book_url | http://dx.doi.org/10.1006/bbrc.1994.2521 |
| datenlieferant | nat_lic_papers |
| fussnote | The G"M"2 activator protein is an essential cofactor of hexosaminidase A in the degradation of G"M"2 ganglioside and it is responsible for the variant AB of G"M"2 gangliosidosis in man. In this study G"M"2 activator protein and its mRNA were determined in different mouse tissues. It was found that this protein is expressed mostly in the spleen and testis followed by brain and kidney which represent the main source in man. It is also interesting that in mouse testis there is a higher expression of the α subunit of hexosaminidase, thus suggesting a relationship between α subunit and G"M"2 activator protein. Furthermore the results indicate that the expression of G"M"2 activator protein is regulated, at least in part, at the transcriptional level. |
| hauptsatz | hsatz_simple |
| identnr | NLZ183472950 |
| issn | 0006-291X |
| journal_name | Biochemical and Biophysical Research Communications |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 204 (1994), S. 741-745 |
| search_space | articles |
| shingle_author_1 | Beccari, T. Palmerini, C.A. Servillo, G. Dellafazia, M.A. Magni, M.P.V. Orlacchio, A. |
| shingle_author_2 | Beccari, T. Palmerini, C.A. Servillo, G. Dellafazia, M.A. Magni, M.P.V. Orlacchio, A. |
| shingle_author_3 | Beccari, T. Palmerini, C.A. Servillo, G. Dellafazia, M.A. Magni, M.P.V. Orlacchio, A. |
| shingle_author_4 | Beccari, T. Palmerini, C.A. Servillo, G. Dellafazia, M.A. Magni, M.P.V. Orlacchio, A. |
| shingle_catch_all_1 | Beccari, T. Palmerini, C.A. Servillo, G. Dellafazia, M.A. Magni, M.P.V. Orlacchio, A. G"M"2 Activator Protein Expression in Mouse Tissues 0006-291X 0006291X Elsevier |
| shingle_catch_all_2 | Beccari, T. Palmerini, C.A. Servillo, G. Dellafazia, M.A. Magni, M.P.V. Orlacchio, A. G"M"2 Activator Protein Expression in Mouse Tissues 0006-291X 0006291X Elsevier |
| shingle_catch_all_3 | Beccari, T. Palmerini, C.A. Servillo, G. Dellafazia, M.A. Magni, M.P.V. Orlacchio, A. G"M"2 Activator Protein Expression in Mouse Tissues 0006-291X 0006291X Elsevier |
| shingle_catch_all_4 | Beccari, T. Palmerini, C.A. Servillo, G. Dellafazia, M.A. Magni, M.P.V. Orlacchio, A. G"M"2 Activator Protein Expression in Mouse Tissues 0006-291X 0006291X Elsevier |
| shingle_title_1 | G"M"2 Activator Protein Expression in Mouse Tissues |
| shingle_title_2 | G"M"2 Activator Protein Expression in Mouse Tissues |
| shingle_title_3 | G"M"2 Activator Protein Expression in Mouse Tissues |
| shingle_title_4 | G"M"2 Activator Protein Expression in Mouse Tissues |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:45:44.620Z |
| titel | G"M"2 Activator Protein Expression in Mouse Tissues |
| titel_suche | G"M"2 Activator Protein Expression in Mouse Tissues The G"M"2 activator protein is an essential cofactor of hexosaminidase A in the degradation of G"M"2 ganglioside and it is responsible for the variant AB of G"M"2 gangliosidosis in man. In this study G"M"2 activator protein and its mRNA were determined in different mouse tissues. It was found that this protein is expressed mostly in the spleen and testis followed by brain and kidney which represent the main source in man. It is also interesting that in mouse testis there is a higher expression of the α subunit of hexosaminidase, thus suggesting a relationship between α subunit and G"M"2 activator protein. Furthermore the results indicate that the expression of G"M"2 activator protein is regulated, at least in part, at the transcriptional level. |
| topic | W V U |
| uid | nat_lic_papers_NLZ183472950 |