G"M"2 Activator Protein Expression in Mouse Tissues - Beccari, T.; Palmerini, C.A.; Servillo, G.; Dellafazia, M.A.; Magni, M.P.V.; Orlacchio, A. (Elsevier)
The G"M"2 activator protein is an essential cofactor of hexosaminidase A in the degradation of G"M"2 ganglioside and it is responsible for the variant AB of G"M"2 gangliosidosis in man. In this study G"M"2 activator protein and its mRNA were determined in different mouse tissues. It was found that this protein is expressed mostly in the spleen and testis followed by brain and kidney which represent the main source in man. It is also interesting that in mouse testis there is a higher expression of the α subunit of hexosaminidase, thus suggesting a relationship between α subunit and G"M"2 activator protein. Furthermore the results indicate that the expression of G"M"2 activator protein is regulated, at least in part, at the transcriptional level.
http://dx.doi.org/10.1006/bbrc.1994.2521
Keywords: W; V; U