Lamotrigine-antiparkinsonian activity by blockade of glutamate release?
| ISSN: |
1435-1463
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|---|---|
| Keywords: |
Glutamate ; excitatory neurotransmitter ; lamotrigine ; Parkinson's disease ; basal ganglia pathways
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Summary Recent experiments provide evidence that the NMDA-antagonist MK-801 has a locomotor-stimulating effect in monoamine-depleted rodents. These findings are based upon a hypothetical pathway-circuit including the basal ganglia as a model reflecting hypo- and hyperkinetic movement disorders. We have treated 5 patients suffering from Parkinson's disease with the antiepileptic drug “lamotrigine” which does not appear to be an NMDA-antagonist but acts functionally as a glutamate antagonist by inhibition of presynaptic glutamate release.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798296151414276096 |
|---|---|
| autor | Zipp, F. Baas, H. Fischer, P. -A. |
| autorsonst | Zipp, F. Baas, H. Fischer, P. -A. |
| book_url | http://dx.doi.org/10.1007/BF02260916 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM208159657 |
| issn | 1435-1463 |
| journal_name | Journal of neural transmission |
| materialart | 1 |
| notes | Summary Recent experiments provide evidence that the NMDA-antagonist MK-801 has a locomotor-stimulating effect in monoamine-depleted rodents. These findings are based upon a hypothetical pathway-circuit including the basal ganglia as a model reflecting hypo- and hyperkinetic movement disorders. We have treated 5 patients suffering from Parkinson's disease with the antiepileptic drug “lamotrigine” which does not appear to be an NMDA-antagonist but acts functionally as a glutamate antagonist by inhibition of presynaptic glutamate release. |
| package_name | Springer |
| publikationsjahr_anzeige | 1993 |
| publikationsjahr_facette | 1993 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1993 |
| publisher | Springer |
| reference | 5 (1993), S. 67-75 |
| schlagwort | Glutamate excitatory neurotransmitter lamotrigine Parkinson's disease basal ganglia pathways |
| search_space | articles |
| shingle_author_1 | Zipp, F. Baas, H. Fischer, P. -A. |
| shingle_author_2 | Zipp, F. Baas, H. Fischer, P. -A. |
| shingle_author_3 | Zipp, F. Baas, H. Fischer, P. -A. |
| shingle_author_4 | Zipp, F. Baas, H. Fischer, P. -A. |
| shingle_catch_all_1 | Zipp, F. Baas, H. Fischer, P. -A. Lamotrigine-antiparkinsonian activity by blockade of glutamate release? Glutamate excitatory neurotransmitter lamotrigine Parkinson's disease basal ganglia pathways Glutamate excitatory neurotransmitter lamotrigine Parkinson's disease basal ganglia pathways Summary Recent experiments provide evidence that the NMDA-antagonist MK-801 has a locomotor-stimulating effect in monoamine-depleted rodents. These findings are based upon a hypothetical pathway-circuit including the basal ganglia as a model reflecting hypo- and hyperkinetic movement disorders. We have treated 5 patients suffering from Parkinson's disease with the antiepileptic drug “lamotrigine” which does not appear to be an NMDA-antagonist but acts functionally as a glutamate antagonist by inhibition of presynaptic glutamate release. 1435-1463 14351463 Springer |
| shingle_catch_all_2 | Zipp, F. Baas, H. Fischer, P. -A. Lamotrigine-antiparkinsonian activity by blockade of glutamate release? Glutamate excitatory neurotransmitter lamotrigine Parkinson's disease basal ganglia pathways Glutamate excitatory neurotransmitter lamotrigine Parkinson's disease basal ganglia pathways Summary Recent experiments provide evidence that the NMDA-antagonist MK-801 has a locomotor-stimulating effect in monoamine-depleted rodents. These findings are based upon a hypothetical pathway-circuit including the basal ganglia as a model reflecting hypo- and hyperkinetic movement disorders. We have treated 5 patients suffering from Parkinson's disease with the antiepileptic drug “lamotrigine” which does not appear to be an NMDA-antagonist but acts functionally as a glutamate antagonist by inhibition of presynaptic glutamate release. 1435-1463 14351463 Springer |
| shingle_catch_all_3 | Zipp, F. Baas, H. Fischer, P. -A. Lamotrigine-antiparkinsonian activity by blockade of glutamate release? Glutamate excitatory neurotransmitter lamotrigine Parkinson's disease basal ganglia pathways Glutamate excitatory neurotransmitter lamotrigine Parkinson's disease basal ganglia pathways Summary Recent experiments provide evidence that the NMDA-antagonist MK-801 has a locomotor-stimulating effect in monoamine-depleted rodents. These findings are based upon a hypothetical pathway-circuit including the basal ganglia as a model reflecting hypo- and hyperkinetic movement disorders. We have treated 5 patients suffering from Parkinson's disease with the antiepileptic drug “lamotrigine” which does not appear to be an NMDA-antagonist but acts functionally as a glutamate antagonist by inhibition of presynaptic glutamate release. 1435-1463 14351463 Springer |
| shingle_catch_all_4 | Zipp, F. Baas, H. Fischer, P. -A. Lamotrigine-antiparkinsonian activity by blockade of glutamate release? Glutamate excitatory neurotransmitter lamotrigine Parkinson's disease basal ganglia pathways Glutamate excitatory neurotransmitter lamotrigine Parkinson's disease basal ganglia pathways Summary Recent experiments provide evidence that the NMDA-antagonist MK-801 has a locomotor-stimulating effect in monoamine-depleted rodents. These findings are based upon a hypothetical pathway-circuit including the basal ganglia as a model reflecting hypo- and hyperkinetic movement disorders. We have treated 5 patients suffering from Parkinson's disease with the antiepileptic drug “lamotrigine” which does not appear to be an NMDA-antagonist but acts functionally as a glutamate antagonist by inhibition of presynaptic glutamate release. 1435-1463 14351463 Springer |
| shingle_title_1 | Lamotrigine-antiparkinsonian activity by blockade of glutamate release? |
| shingle_title_2 | Lamotrigine-antiparkinsonian activity by blockade of glutamate release? |
| shingle_title_3 | Lamotrigine-antiparkinsonian activity by blockade of glutamate release? |
| shingle_title_4 | Lamotrigine-antiparkinsonian activity by blockade of glutamate release? |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:47:29.681Z |
| titel | Lamotrigine-antiparkinsonian activity by blockade of glutamate release? |
| titel_suche | Lamotrigine-antiparkinsonian activity by blockade of glutamate release? |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM208159657 |