Lamotrigine-antiparkinsonian activity by blockade of glutamate release?
| ISSN: |
1435-1463
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| Keywords: |
Glutamate ; excitatory neurotransmitter ; lamotrigine ; Parkinson's disease ; basal ganglia pathways
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Summary Recent experiments provide evidence that the NMDA-antagonist MK-801 has a locomotor-stimulating effect in monoamine-depleted rodents. These findings are based upon a hypothetical pathway-circuit including the basal ganglia as a model reflecting hypo- and hyperkinetic movement disorders. We have treated 5 patients suffering from Parkinson's disease with the antiepileptic drug “lamotrigine” which does not appear to be an NMDA-antagonist but acts functionally as a glutamate antagonist by inhibition of presynaptic glutamate release.
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| Type of Medium: |
Electronic Resource
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| URL: |