The accumulation and disposition of benz(a)acridine in the fathead minnow,Pimephales promelas
| ISSN: |
1432-0703
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Energy, Environment Protection, Nuclear Power Engineering
Medicine
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| Notes: |
Abstract The bioconcentration and metabolism of benz(a)acridine in fathead minnows (Pimephales promelas) was investigated using14C-labelled benz(a)acridine. The rates of uptake, elimination, and metabolic transformation of benz(a)acridine were estimated in the fish. The equilibrium concentration factor [ratio of benz(a)acridine concentration in fish (wet weight) to benz(a)acridine concentration in water] was estimated at 106±17. The observed bioconcentration factor was about one tenth of that predicted by octanol-water partitioning models. Metabolic alteration was estimated to reduce the degree of bioconcentration 50 to 90% from the hypothetical case in which metabolic transformation did not occur. Benz(a)acridine metabolites attained concentrations in the fish considerably in excess of benz(a)acridine itself.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295465571123200 |
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| autor | Southworth, G. R. Keffer, C. C. Beauchamp, J. J. |
| autorsonst | Southworth, G. R. Keffer, C. C. Beauchamp, J. J. |
| book_url | http://dx.doi.org/10.1007/BF01054879 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM207114803 |
| issn | 1432-0703 |
| journal_name | Archives of environmental contamination and toxicology |
| materialart | 1 |
| notes | Abstract The bioconcentration and metabolism of benz(a)acridine in fathead minnows (Pimephales promelas) was investigated using14C-labelled benz(a)acridine. The rates of uptake, elimination, and metabolic transformation of benz(a)acridine were estimated in the fish. The equilibrium concentration factor [ratio of benz(a)acridine concentration in fish (wet weight) to benz(a)acridine concentration in water] was estimated at 106±17. The observed bioconcentration factor was about one tenth of that predicted by octanol-water partitioning models. Metabolic alteration was estimated to reduce the degree of bioconcentration 50 to 90% from the hypothetical case in which metabolic transformation did not occur. Benz(a)acridine metabolites attained concentrations in the fish considerably in excess of benz(a)acridine itself. |
| package_name | Springer |
| publikationsjahr_anzeige | 1981 |
| publikationsjahr_facette | 1981 |
| publikationsjahr_intervall | 8019:1980-1984 |
| publikationsjahr_sort | 1981 |
| publisher | Springer |
| reference | 10 (1981), S. 561-569 |
| search_space | articles |
| shingle_author_1 | Southworth, G. R. Keffer, C. C. Beauchamp, J. J. |
| shingle_author_2 | Southworth, G. R. Keffer, C. C. Beauchamp, J. J. |
| shingle_author_3 | Southworth, G. R. Keffer, C. C. Beauchamp, J. J. |
| shingle_author_4 | Southworth, G. R. Keffer, C. C. Beauchamp, J. J. |
| shingle_catch_all_1 | Southworth, G. R. Keffer, C. C. Beauchamp, J. J. The accumulation and disposition of benz(a)acridine in the fathead minnow,Pimephales promelas Abstract The bioconcentration and metabolism of benz(a)acridine in fathead minnows (Pimephales promelas) was investigated using14C-labelled benz(a)acridine. The rates of uptake, elimination, and metabolic transformation of benz(a)acridine were estimated in the fish. The equilibrium concentration factor [ratio of benz(a)acridine concentration in fish (wet weight) to benz(a)acridine concentration in water] was estimated at 106±17. The observed bioconcentration factor was about one tenth of that predicted by octanol-water partitioning models. Metabolic alteration was estimated to reduce the degree of bioconcentration 50 to 90% from the hypothetical case in which metabolic transformation did not occur. Benz(a)acridine metabolites attained concentrations in the fish considerably in excess of benz(a)acridine itself. 1432-0703 14320703 Springer |
| shingle_catch_all_2 | Southworth, G. R. Keffer, C. C. Beauchamp, J. J. The accumulation and disposition of benz(a)acridine in the fathead minnow,Pimephales promelas Abstract The bioconcentration and metabolism of benz(a)acridine in fathead minnows (Pimephales promelas) was investigated using14C-labelled benz(a)acridine. The rates of uptake, elimination, and metabolic transformation of benz(a)acridine were estimated in the fish. The equilibrium concentration factor [ratio of benz(a)acridine concentration in fish (wet weight) to benz(a)acridine concentration in water] was estimated at 106±17. The observed bioconcentration factor was about one tenth of that predicted by octanol-water partitioning models. Metabolic alteration was estimated to reduce the degree of bioconcentration 50 to 90% from the hypothetical case in which metabolic transformation did not occur. Benz(a)acridine metabolites attained concentrations in the fish considerably in excess of benz(a)acridine itself. 1432-0703 14320703 Springer |
| shingle_catch_all_3 | Southworth, G. R. Keffer, C. C. Beauchamp, J. J. The accumulation and disposition of benz(a)acridine in the fathead minnow,Pimephales promelas Abstract The bioconcentration and metabolism of benz(a)acridine in fathead minnows (Pimephales promelas) was investigated using14C-labelled benz(a)acridine. The rates of uptake, elimination, and metabolic transformation of benz(a)acridine were estimated in the fish. The equilibrium concentration factor [ratio of benz(a)acridine concentration in fish (wet weight) to benz(a)acridine concentration in water] was estimated at 106±17. The observed bioconcentration factor was about one tenth of that predicted by octanol-water partitioning models. Metabolic alteration was estimated to reduce the degree of bioconcentration 50 to 90% from the hypothetical case in which metabolic transformation did not occur. Benz(a)acridine metabolites attained concentrations in the fish considerably in excess of benz(a)acridine itself. 1432-0703 14320703 Springer |
| shingle_catch_all_4 | Southworth, G. R. Keffer, C. C. Beauchamp, J. J. The accumulation and disposition of benz(a)acridine in the fathead minnow,Pimephales promelas Abstract The bioconcentration and metabolism of benz(a)acridine in fathead minnows (Pimephales promelas) was investigated using14C-labelled benz(a)acridine. The rates of uptake, elimination, and metabolic transformation of benz(a)acridine were estimated in the fish. The equilibrium concentration factor [ratio of benz(a)acridine concentration in fish (wet weight) to benz(a)acridine concentration in water] was estimated at 106±17. The observed bioconcentration factor was about one tenth of that predicted by octanol-water partitioning models. Metabolic alteration was estimated to reduce the degree of bioconcentration 50 to 90% from the hypothetical case in which metabolic transformation did not occur. Benz(a)acridine metabolites attained concentrations in the fish considerably in excess of benz(a)acridine itself. 1432-0703 14320703 Springer |
| shingle_title_1 | The accumulation and disposition of benz(a)acridine in the fathead minnow,Pimephales promelas |
| shingle_title_2 | The accumulation and disposition of benz(a)acridine in the fathead minnow,Pimephales promelas |
| shingle_title_3 | The accumulation and disposition of benz(a)acridine in the fathead minnow,Pimephales promelas |
| shingle_title_4 | The accumulation and disposition of benz(a)acridine in the fathead minnow,Pimephales promelas |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:36:38.631Z |
| titel | The accumulation and disposition of benz(a)acridine in the fathead minnow,Pimephales promelas |
| titel_suche | The accumulation and disposition of benz(a)acridine in the fathead minnow,Pimephales promelas |
| topic | ZP WW-YZ |
| uid | nat_lic_papers_NLM207114803 |