The accumulation and disposition of benz(a)acridine in the fathead minnow,Pimephales promelas
| ISSN: |
1432-0703
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Energy, Environment Protection, Nuclear Power Engineering
Medicine
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| Notes: |
Abstract The bioconcentration and metabolism of benz(a)acridine in fathead minnows (Pimephales promelas) was investigated using14C-labelled benz(a)acridine. The rates of uptake, elimination, and metabolic transformation of benz(a)acridine were estimated in the fish. The equilibrium concentration factor [ratio of benz(a)acridine concentration in fish (wet weight) to benz(a)acridine concentration in water] was estimated at 106±17. The observed bioconcentration factor was about one tenth of that predicted by octanol-water partitioning models. Metabolic alteration was estimated to reduce the degree of bioconcentration 50 to 90% from the hypothetical case in which metabolic transformation did not occur. Benz(a)acridine metabolites attained concentrations in the fish considerably in excess of benz(a)acridine itself.
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| Type of Medium: |
Electronic Resource
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| URL: |