Myotonic dystrophy is closely linked to the gene for muscle-type creatine kinase (CKMM)
Brunner, H. G. ; Korneluk, R. G. ; Coerwinkel-Driessen, M. ; MacKenzie, A. ; Smeets, H. ; Lambermon, H. M. M. ; Oost, B. A. ; Wieringa, B. ; Ropers, H. -H.
Springer
Published 1989
Springer
Published 1989
| ISSN: |
1432-1203
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Biology
Medicine
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| Notes: |
Summary We have studied genetic linkage between the gene for creatine kinase muscle type (CKMM) and the gene for myotonic dystrophy (DM). In a panel of 65 myotonic dystrophy families from Canada and the Netherlands, a maximum lod score (Zmax) of 22.8 at a recombination frequency (Θ) of 0.03 was obtained. Tight linkage was also demonstrated for CKMM and the gene for apolipoprotein C2 (ApoC2). This establishes CKMM as a useful marker for myotonic dystrophy.
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| Type of Medium: |
Electronic Resource
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| URL: |