In vitro synthesized immunoglobulin A from nu/+ and reconstituted nu/nu mice against a dominant surface antigen ofGiardia lamblia
| ISSN: |
1432-1955
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Biology
Medicine
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| Notes: |
Abstract Nu/+ mice (ZU.ICR-strain) experimentally infected withGiardia lamblia (clone GS/M-83-H7) cleared the infection by day 45 postinfection (p.i.). Athymic nu/nu mice were reconstituted with immune Peyer's patch lymphocytes obtained from self-healed nu/+ littermates and thus acquired the potential to decrease their intestinal parasite mass. Intestinal B-cells from self-healed nu/+ mice as well as from immune-reconstituted athymic nude mice synthesized in vitro parasite-specific immunoglobulin A (IgA). This IgA was subsequently analyzed by immunoblotting, showing a predominant reaction with the major surface antigen (a 72000-Da polypeptide) characterizing theGiardia clone in question. The hypothesis on the causative role of intestinal IgA and immune lymphocytes in the control ofG. lamblia infection thus deserves further attention.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798297665609400323 |
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| autor | Gottstein, B. Deplazes, P. Tanner, I. |
| autorsonst | Gottstein, B. Deplazes, P. Tanner, I. |
| book_url | http://dx.doi.org/10.1007/BF00932506 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM205416578 |
| issn | 1432-1955 |
| journal_name | Parasitology research |
| materialart | 1 |
| notes | Abstract Nu/+ mice (ZU.ICR-strain) experimentally infected withGiardia lamblia (clone GS/M-83-H7) cleared the infection by day 45 postinfection (p.i.). Athymic nu/nu mice were reconstituted with immune Peyer's patch lymphocytes obtained from self-healed nu/+ littermates and thus acquired the potential to decrease their intestinal parasite mass. Intestinal B-cells from self-healed nu/+ mice as well as from immune-reconstituted athymic nude mice synthesized in vitro parasite-specific immunoglobulin A (IgA). This IgA was subsequently analyzed by immunoblotting, showing a predominant reaction with the major surface antigen (a 72000-Da polypeptide) characterizing theGiardia clone in question. The hypothesis on the causative role of intestinal IgA and immune lymphocytes in the control ofG. lamblia infection thus deserves further attention. |
| package_name | Springer |
| publikationsjahr_anzeige | 1993 |
| publikationsjahr_facette | 1993 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1993 |
| publisher | Springer |
| reference | 79 (1993), S. 644-648 |
| search_space | articles |
| shingle_author_1 | Gottstein, B. Deplazes, P. Tanner, I. |
| shingle_author_2 | Gottstein, B. Deplazes, P. Tanner, I. |
| shingle_author_3 | Gottstein, B. Deplazes, P. Tanner, I. |
| shingle_author_4 | Gottstein, B. Deplazes, P. Tanner, I. |
| shingle_catch_all_1 | Gottstein, B. Deplazes, P. Tanner, I. In vitro synthesized immunoglobulin A from nu/+ and reconstituted nu/nu mice against a dominant surface antigen ofGiardia lamblia Abstract Nu/+ mice (ZU.ICR-strain) experimentally infected withGiardia lamblia (clone GS/M-83-H7) cleared the infection by day 45 postinfection (p.i.). Athymic nu/nu mice were reconstituted with immune Peyer's patch lymphocytes obtained from self-healed nu/+ littermates and thus acquired the potential to decrease their intestinal parasite mass. Intestinal B-cells from self-healed nu/+ mice as well as from immune-reconstituted athymic nude mice synthesized in vitro parasite-specific immunoglobulin A (IgA). This IgA was subsequently analyzed by immunoblotting, showing a predominant reaction with the major surface antigen (a 72000-Da polypeptide) characterizing theGiardia clone in question. The hypothesis on the causative role of intestinal IgA and immune lymphocytes in the control ofG. lamblia infection thus deserves further attention. 1432-1955 14321955 Springer |
| shingle_catch_all_2 | Gottstein, B. Deplazes, P. Tanner, I. In vitro synthesized immunoglobulin A from nu/+ and reconstituted nu/nu mice against a dominant surface antigen ofGiardia lamblia Abstract Nu/+ mice (ZU.ICR-strain) experimentally infected withGiardia lamblia (clone GS/M-83-H7) cleared the infection by day 45 postinfection (p.i.). Athymic nu/nu mice were reconstituted with immune Peyer's patch lymphocytes obtained from self-healed nu/+ littermates and thus acquired the potential to decrease their intestinal parasite mass. Intestinal B-cells from self-healed nu/+ mice as well as from immune-reconstituted athymic nude mice synthesized in vitro parasite-specific immunoglobulin A (IgA). This IgA was subsequently analyzed by immunoblotting, showing a predominant reaction with the major surface antigen (a 72000-Da polypeptide) characterizing theGiardia clone in question. The hypothesis on the causative role of intestinal IgA and immune lymphocytes in the control ofG. lamblia infection thus deserves further attention. 1432-1955 14321955 Springer |
| shingle_catch_all_3 | Gottstein, B. Deplazes, P. Tanner, I. In vitro synthesized immunoglobulin A from nu/+ and reconstituted nu/nu mice against a dominant surface antigen ofGiardia lamblia Abstract Nu/+ mice (ZU.ICR-strain) experimentally infected withGiardia lamblia (clone GS/M-83-H7) cleared the infection by day 45 postinfection (p.i.). Athymic nu/nu mice were reconstituted with immune Peyer's patch lymphocytes obtained from self-healed nu/+ littermates and thus acquired the potential to decrease their intestinal parasite mass. Intestinal B-cells from self-healed nu/+ mice as well as from immune-reconstituted athymic nude mice synthesized in vitro parasite-specific immunoglobulin A (IgA). This IgA was subsequently analyzed by immunoblotting, showing a predominant reaction with the major surface antigen (a 72000-Da polypeptide) characterizing theGiardia clone in question. The hypothesis on the causative role of intestinal IgA and immune lymphocytes in the control ofG. lamblia infection thus deserves further attention. 1432-1955 14321955 Springer |
| shingle_catch_all_4 | Gottstein, B. Deplazes, P. Tanner, I. In vitro synthesized immunoglobulin A from nu/+ and reconstituted nu/nu mice against a dominant surface antigen ofGiardia lamblia Abstract Nu/+ mice (ZU.ICR-strain) experimentally infected withGiardia lamblia (clone GS/M-83-H7) cleared the infection by day 45 postinfection (p.i.). Athymic nu/nu mice were reconstituted with immune Peyer's patch lymphocytes obtained from self-healed nu/+ littermates and thus acquired the potential to decrease their intestinal parasite mass. Intestinal B-cells from self-healed nu/+ mice as well as from immune-reconstituted athymic nude mice synthesized in vitro parasite-specific immunoglobulin A (IgA). This IgA was subsequently analyzed by immunoblotting, showing a predominant reaction with the major surface antigen (a 72000-Da polypeptide) characterizing theGiardia clone in question. The hypothesis on the causative role of intestinal IgA and immune lymphocytes in the control ofG. lamblia infection thus deserves further attention. 1432-1955 14321955 Springer |
| shingle_title_1 | In vitro synthesized immunoglobulin A from nu/+ and reconstituted nu/nu mice against a dominant surface antigen ofGiardia lamblia |
| shingle_title_2 | In vitro synthesized immunoglobulin A from nu/+ and reconstituted nu/nu mice against a dominant surface antigen ofGiardia lamblia |
| shingle_title_3 | In vitro synthesized immunoglobulin A from nu/+ and reconstituted nu/nu mice against a dominant surface antigen ofGiardia lamblia |
| shingle_title_4 | In vitro synthesized immunoglobulin A from nu/+ and reconstituted nu/nu mice against a dominant surface antigen ofGiardia lamblia |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T10:11:36.790Z |
| titel | In vitro synthesized immunoglobulin A from nu/+ and reconstituted nu/nu mice against a dominant surface antigen ofGiardia lamblia |
| titel_suche | In vitro synthesized immunoglobulin A from nu/+ and reconstituted nu/nu mice against a dominant surface antigen ofGiardia lamblia |
| topic | W WW-YZ |
| uid | nat_lic_papers_NLM205416578 |