The immune response in iron-deficient young children: Effect of iron supplementation on cell-mediated immunity
Thibault, H. ; Galan, P. ; Selz, F. ; Preziosi, P. ; Olivier, C. ; Badoual, J. ; Hercberg, S.
Springer
Published 1993
Springer
Published 1993
| ISSN: |
1432-1076
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|---|---|
| Keywords: |
Iron deficiency ; Iron supplementation ; Immune functions ; Cell-mediated immunity ; Interleukin-2
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract The effects of iron deficiency on immunity remain controversial. This study was designed to assess the impact of iron supplementation on the immune status, in 81 children aged 6 months–3 years, at high risk for iron deficiency, using a longitudinal double blind randomised and placebo-controlled study. Lymphocytes of iron-deficient children produced less interleukin-2 in vitro. Iron supplementation for 2 months increased mean corpuscular volume, serum ferritin and serum transferrin, but had no effect on the parameters of T-cell mediated immunity. The lower interleukin-2 levels in iron-deficient suggest that cell-mediated immunity may be impaired in iron deficiency.
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| Type of Medium: |
Electronic Resource
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| URL: |