Myasthenic syndrome and oligoclonal lymphocytosis: evolution into chronic lymphocytic leukemia
Radossi, P. ; Dazzi, F. ; de Franchis, G. ; Vianello, F. ; Tison, T. ; Menin, C. ; Montagna, M. ; D'Andrea, E.
Springer
Published 1998
Springer
Published 1998
| ISSN: |
1432-0584
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|---|---|
| Keywords: |
KEy words Myasthenic syndrome ; B-CLL ; Neoplastic progression ; IgH gene rearrangement ; Semi-nested PCR
|
| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Medicine
|
| Notes: |
Abstracts We report a patient with myasthenic syndrome who, 2 years after diagnosis, developed an oligoclonal lymphocytosis. This disorder was sustained by both κ+ and λ+ CD5+ B-cell clones; over the following year, the white blood cell count increased and phenotypic characterization revealed a clear imbalance in the immunoglobulin light chain ratio (84% κ+). Accordingly, persistence of a κ+ B-cell clone was disclosed by molecular analysis of immunoglobulin heavy chain gene rearrangements. Our results may suggest that prolonged immune system stimulation due to an autoimmune disease can drive a benign lymphoproliferation into a B-cell neoplastic process.
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| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798295419458945025 |
|---|---|
| autor | Radossi, P. Dazzi, F. de Franchis, G. Vianello, F. Tison, T. Menin, C. Montagna, M. D'Andrea, E. |
| autorsonst | Radossi, P. Dazzi, F. de Franchis, G. Vianello, F. Tison, T. Menin, C. Montagna, M. D'Andrea, E. |
| book_url | http://dx.doi.org/10.1007/s002770050360 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM20298009X |
| issn | 1432-0584 |
| journal_name | Annals of hematology |
| materialart | 1 |
| notes | Abstracts We report a patient with myasthenic syndrome who, 2 years after diagnosis, developed an oligoclonal lymphocytosis. This disorder was sustained by both κ+ and λ+ CD5+ B-cell clones; over the following year, the white blood cell count increased and phenotypic characterization revealed a clear imbalance in the immunoglobulin light chain ratio (84% κ+). Accordingly, persistence of a κ+ B-cell clone was disclosed by molecular analysis of immunoglobulin heavy chain gene rearrangements. Our results may suggest that prolonged immune system stimulation due to an autoimmune disease can drive a benign lymphoproliferation into a B-cell neoplastic process. |
| package_name | Springer |
| publikationsjahr_anzeige | 1998 |
| publikationsjahr_facette | 1998 |
| publikationsjahr_intervall | 8004:1995-1999 |
| publikationsjahr_sort | 1998 |
| publisher | Springer |
| reference | 76 (1998), S. 45-47 |
| schlagwort | KEy words Myasthenic syndrome B-CLL Neoplastic progression IgH gene rearrangement Semi-nested PCR |
| search_space | articles |
| shingle_author_1 | Radossi, P. Dazzi, F. de Franchis, G. Vianello, F. Tison, T. Menin, C. Montagna, M. D'Andrea, E. |
| shingle_author_2 | Radossi, P. Dazzi, F. de Franchis, G. Vianello, F. Tison, T. Menin, C. Montagna, M. D'Andrea, E. |
| shingle_author_3 | Radossi, P. Dazzi, F. de Franchis, G. Vianello, F. Tison, T. Menin, C. Montagna, M. D'Andrea, E. |
| shingle_author_4 | Radossi, P. Dazzi, F. de Franchis, G. Vianello, F. Tison, T. Menin, C. Montagna, M. D'Andrea, E. |
| shingle_catch_all_1 | Radossi, P. Dazzi, F. de Franchis, G. Vianello, F. Tison, T. Menin, C. Montagna, M. D'Andrea, E. Myasthenic syndrome and oligoclonal lymphocytosis: evolution into chronic lymphocytic leukemia KEy words Myasthenic syndrome B-CLL Neoplastic progression IgH gene rearrangement Semi-nested PCR KEy words Myasthenic syndrome B-CLL Neoplastic progression IgH gene rearrangement Semi-nested PCR Abstracts We report a patient with myasthenic syndrome who, 2 years after diagnosis, developed an oligoclonal lymphocytosis. This disorder was sustained by both κ+ and λ+ CD5+ B-cell clones; over the following year, the white blood cell count increased and phenotypic characterization revealed a clear imbalance in the immunoglobulin light chain ratio (84% κ+). Accordingly, persistence of a κ+ B-cell clone was disclosed by molecular analysis of immunoglobulin heavy chain gene rearrangements. Our results may suggest that prolonged immune system stimulation due to an autoimmune disease can drive a benign lymphoproliferation into a B-cell neoplastic process. 1432-0584 14320584 Springer |
| shingle_catch_all_2 | Radossi, P. Dazzi, F. de Franchis, G. Vianello, F. Tison, T. Menin, C. Montagna, M. D'Andrea, E. Myasthenic syndrome and oligoclonal lymphocytosis: evolution into chronic lymphocytic leukemia KEy words Myasthenic syndrome B-CLL Neoplastic progression IgH gene rearrangement Semi-nested PCR KEy words Myasthenic syndrome B-CLL Neoplastic progression IgH gene rearrangement Semi-nested PCR Abstracts We report a patient with myasthenic syndrome who, 2 years after diagnosis, developed an oligoclonal lymphocytosis. This disorder was sustained by both κ+ and λ+ CD5+ B-cell clones; over the following year, the white blood cell count increased and phenotypic characterization revealed a clear imbalance in the immunoglobulin light chain ratio (84% κ+). Accordingly, persistence of a κ+ B-cell clone was disclosed by molecular analysis of immunoglobulin heavy chain gene rearrangements. Our results may suggest that prolonged immune system stimulation due to an autoimmune disease can drive a benign lymphoproliferation into a B-cell neoplastic process. 1432-0584 14320584 Springer |
| shingle_catch_all_3 | Radossi, P. Dazzi, F. de Franchis, G. Vianello, F. Tison, T. Menin, C. Montagna, M. D'Andrea, E. Myasthenic syndrome and oligoclonal lymphocytosis: evolution into chronic lymphocytic leukemia KEy words Myasthenic syndrome B-CLL Neoplastic progression IgH gene rearrangement Semi-nested PCR KEy words Myasthenic syndrome B-CLL Neoplastic progression IgH gene rearrangement Semi-nested PCR Abstracts We report a patient with myasthenic syndrome who, 2 years after diagnosis, developed an oligoclonal lymphocytosis. This disorder was sustained by both κ+ and λ+ CD5+ B-cell clones; over the following year, the white blood cell count increased and phenotypic characterization revealed a clear imbalance in the immunoglobulin light chain ratio (84% κ+). Accordingly, persistence of a κ+ B-cell clone was disclosed by molecular analysis of immunoglobulin heavy chain gene rearrangements. Our results may suggest that prolonged immune system stimulation due to an autoimmune disease can drive a benign lymphoproliferation into a B-cell neoplastic process. 1432-0584 14320584 Springer |
| shingle_catch_all_4 | Radossi, P. Dazzi, F. de Franchis, G. Vianello, F. Tison, T. Menin, C. Montagna, M. D'Andrea, E. Myasthenic syndrome and oligoclonal lymphocytosis: evolution into chronic lymphocytic leukemia KEy words Myasthenic syndrome B-CLL Neoplastic progression IgH gene rearrangement Semi-nested PCR KEy words Myasthenic syndrome B-CLL Neoplastic progression IgH gene rearrangement Semi-nested PCR Abstracts We report a patient with myasthenic syndrome who, 2 years after diagnosis, developed an oligoclonal lymphocytosis. This disorder was sustained by both κ+ and λ+ CD5+ B-cell clones; over the following year, the white blood cell count increased and phenotypic characterization revealed a clear imbalance in the immunoglobulin light chain ratio (84% κ+). Accordingly, persistence of a κ+ B-cell clone was disclosed by molecular analysis of immunoglobulin heavy chain gene rearrangements. Our results may suggest that prolonged immune system stimulation due to an autoimmune disease can drive a benign lymphoproliferation into a B-cell neoplastic process. 1432-0584 14320584 Springer |
| shingle_title_1 | Myasthenic syndrome and oligoclonal lymphocytosis: evolution into chronic lymphocytic leukemia |
| shingle_title_2 | Myasthenic syndrome and oligoclonal lymphocytosis: evolution into chronic lymphocytic leukemia |
| shingle_title_3 | Myasthenic syndrome and oligoclonal lymphocytosis: evolution into chronic lymphocytic leukemia |
| shingle_title_4 | Myasthenic syndrome and oligoclonal lymphocytosis: evolution into chronic lymphocytic leukemia |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:35:54.635Z |
| titel | Myasthenic syndrome and oligoclonal lymphocytosis: evolution into chronic lymphocytic leukemia |
| titel_suche | Myasthenic syndrome and oligoclonal lymphocytosis: evolution into chronic lymphocytic leukemia |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM20298009X |