Myasthenic syndrome and oligoclonal lymphocytosis: evolution into chronic lymphocytic leukemia
Radossi, P. ; Dazzi, F. ; de Franchis, G. ; Vianello, F. ; Tison, T. ; Menin, C. ; Montagna, M. ; D'Andrea, E.
Springer
Published 1998
Springer
Published 1998
| ISSN: |
1432-0584
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|---|---|
| Keywords: |
KEy words Myasthenic syndrome ; B-CLL ; Neoplastic progression ; IgH gene rearrangement ; Semi-nested PCR
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstracts We report a patient with myasthenic syndrome who, 2 years after diagnosis, developed an oligoclonal lymphocytosis. This disorder was sustained by both κ+ and λ+ CD5+ B-cell clones; over the following year, the white blood cell count increased and phenotypic characterization revealed a clear imbalance in the immunoglobulin light chain ratio (84% κ+). Accordingly, persistence of a κ+ B-cell clone was disclosed by molecular analysis of immunoglobulin heavy chain gene rearrangements. Our results may suggest that prolonged immune system stimulation due to an autoimmune disease can drive a benign lymphoproliferation into a B-cell neoplastic process.
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| Type of Medium: |
Electronic Resource
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| URL: |