Germline TCR-A restriction of immunoglobulin E responses to allergen
Moffatt, M. F. ; Schou, Carsten ; Faux, Jennie A. ; Cookson, William O. C. M.
Springer
Published 1997
Springer
Published 1997
| ISSN: |
1432-1211
|
|---|---|
| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Biology
Medicine
|
| Notes: |
Abstract Immunoglobulin E responses to known environmental antigens (allergens) may serve as a general model to investigate germline genetic restriction of the immune response. We have previously shown genetic linkage between IgE responses to major allergens and the T-cell receptor (TCR) A/D locus, but not to TCR-B, implying that elements in TCR A/D restrict the ability to react to specific antigens. We now show, in two sets of subjects from the same population, a strong allelic association between a VA8.1 polymorphism (VA8.1 * 2) and reactivity to Der p II, a major antigenic component of the house dust mite Dermatophagoides pteronyssinus. Association was also seen between Der p II IgE titres and HLA-DRB1 * 1501 alleles. Reactivity to Der p II was confined to subjects who were positive for VA8.1 * 2 and HLA-DRB1 * 1501, demonstrating germline HLA-DR and TCR-A interaction in restricting the response to exogenous antigen.
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798295629060898819 |
|---|---|
| autor | Moffatt, M. F. Schou, Carsten Faux, Jennie A. Cookson, William O. C. M. |
| autorsonst | Moffatt, M. F. Schou, Carsten Faux, Jennie A. Cookson, William O. C. M. |
| book_url | http://dx.doi.org/10.1007/s002510050266 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM202697614 |
| issn | 1432-1211 |
| journal_name | Immunogenetics |
| materialart | 1 |
| notes | Abstract Immunoglobulin E responses to known environmental antigens (allergens) may serve as a general model to investigate germline genetic restriction of the immune response. We have previously shown genetic linkage between IgE responses to major allergens and the T-cell receptor (TCR) A/D locus, but not to TCR-B, implying that elements in TCR A/D restrict the ability to react to specific antigens. We now show, in two sets of subjects from the same population, a strong allelic association between a VA8.1 polymorphism (VA8.1 * 2) and reactivity to Der p II, a major antigenic component of the house dust mite Dermatophagoides pteronyssinus. Association was also seen between Der p II IgE titres and HLA-DRB1 * 1501 alleles. Reactivity to Der p II was confined to subjects who were positive for VA8.1 * 2 and HLA-DRB1 * 1501, demonstrating germline HLA-DR and TCR-A interaction in restricting the response to exogenous antigen. |
| package_name | Springer |
| publikationsjahr_anzeige | 1997 |
| publikationsjahr_facette | 1997 |
| publikationsjahr_intervall | 8004:1995-1999 |
| publikationsjahr_sort | 1997 |
| publisher | Springer |
| reference | 46 (1997), S. 226-230 |
| search_space | articles |
| shingle_author_1 | Moffatt, M. F. Schou, Carsten Faux, Jennie A. Cookson, William O. C. M. |
| shingle_author_2 | Moffatt, M. F. Schou, Carsten Faux, Jennie A. Cookson, William O. C. M. |
| shingle_author_3 | Moffatt, M. F. Schou, Carsten Faux, Jennie A. Cookson, William O. C. M. |
| shingle_author_4 | Moffatt, M. F. Schou, Carsten Faux, Jennie A. Cookson, William O. C. M. |
| shingle_catch_all_1 | Moffatt, M. F. Schou, Carsten Faux, Jennie A. Cookson, William O. C. M. Germline TCR-A restriction of immunoglobulin E responses to allergen Abstract Immunoglobulin E responses to known environmental antigens (allergens) may serve as a general model to investigate germline genetic restriction of the immune response. We have previously shown genetic linkage between IgE responses to major allergens and the T-cell receptor (TCR) A/D locus, but not to TCR-B, implying that elements in TCR A/D restrict the ability to react to specific antigens. We now show, in two sets of subjects from the same population, a strong allelic association between a VA8.1 polymorphism (VA8.1 * 2) and reactivity to Der p II, a major antigenic component of the house dust mite Dermatophagoides pteronyssinus. Association was also seen between Der p II IgE titres and HLA-DRB1 * 1501 alleles. Reactivity to Der p II was confined to subjects who were positive for VA8.1 * 2 and HLA-DRB1 * 1501, demonstrating germline HLA-DR and TCR-A interaction in restricting the response to exogenous antigen. 1432-1211 14321211 Springer |
| shingle_catch_all_2 | Moffatt, M. F. Schou, Carsten Faux, Jennie A. Cookson, William O. C. M. Germline TCR-A restriction of immunoglobulin E responses to allergen Abstract Immunoglobulin E responses to known environmental antigens (allergens) may serve as a general model to investigate germline genetic restriction of the immune response. We have previously shown genetic linkage between IgE responses to major allergens and the T-cell receptor (TCR) A/D locus, but not to TCR-B, implying that elements in TCR A/D restrict the ability to react to specific antigens. We now show, in two sets of subjects from the same population, a strong allelic association between a VA8.1 polymorphism (VA8.1 * 2) and reactivity to Der p II, a major antigenic component of the house dust mite Dermatophagoides pteronyssinus. Association was also seen between Der p II IgE titres and HLA-DRB1 * 1501 alleles. Reactivity to Der p II was confined to subjects who were positive for VA8.1 * 2 and HLA-DRB1 * 1501, demonstrating germline HLA-DR and TCR-A interaction in restricting the response to exogenous antigen. 1432-1211 14321211 Springer |
| shingle_catch_all_3 | Moffatt, M. F. Schou, Carsten Faux, Jennie A. Cookson, William O. C. M. Germline TCR-A restriction of immunoglobulin E responses to allergen Abstract Immunoglobulin E responses to known environmental antigens (allergens) may serve as a general model to investigate germline genetic restriction of the immune response. We have previously shown genetic linkage between IgE responses to major allergens and the T-cell receptor (TCR) A/D locus, but not to TCR-B, implying that elements in TCR A/D restrict the ability to react to specific antigens. We now show, in two sets of subjects from the same population, a strong allelic association between a VA8.1 polymorphism (VA8.1 * 2) and reactivity to Der p II, a major antigenic component of the house dust mite Dermatophagoides pteronyssinus. Association was also seen between Der p II IgE titres and HLA-DRB1 * 1501 alleles. Reactivity to Der p II was confined to subjects who were positive for VA8.1 * 2 and HLA-DRB1 * 1501, demonstrating germline HLA-DR and TCR-A interaction in restricting the response to exogenous antigen. 1432-1211 14321211 Springer |
| shingle_catch_all_4 | Moffatt, M. F. Schou, Carsten Faux, Jennie A. Cookson, William O. C. M. Germline TCR-A restriction of immunoglobulin E responses to allergen Abstract Immunoglobulin E responses to known environmental antigens (allergens) may serve as a general model to investigate germline genetic restriction of the immune response. We have previously shown genetic linkage between IgE responses to major allergens and the T-cell receptor (TCR) A/D locus, but not to TCR-B, implying that elements in TCR A/D restrict the ability to react to specific antigens. We now show, in two sets of subjects from the same population, a strong allelic association between a VA8.1 polymorphism (VA8.1 * 2) and reactivity to Der p II, a major antigenic component of the house dust mite Dermatophagoides pteronyssinus. Association was also seen between Der p II IgE titres and HLA-DRB1 * 1501 alleles. Reactivity to Der p II was confined to subjects who were positive for VA8.1 * 2 and HLA-DRB1 * 1501, demonstrating germline HLA-DR and TCR-A interaction in restricting the response to exogenous antigen. 1432-1211 14321211 Springer |
| shingle_title_1 | Germline TCR-A restriction of immunoglobulin E responses to allergen |
| shingle_title_2 | Germline TCR-A restriction of immunoglobulin E responses to allergen |
| shingle_title_3 | Germline TCR-A restriction of immunoglobulin E responses to allergen |
| shingle_title_4 | Germline TCR-A restriction of immunoglobulin E responses to allergen |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:39:14.427Z |
| titel | Germline TCR-A restriction of immunoglobulin E responses to allergen |
| titel_suche | Germline TCR-A restriction of immunoglobulin E responses to allergen |
| topic | W WW-YZ |
| uid | nat_lic_papers_NLM202697614 |