Germline TCR-A restriction of immunoglobulin E responses to allergen
Moffatt, M. F. ; Schou, Carsten ; Faux, Jennie A. ; Cookson, William O. C. M.
Springer
Published 1997
Springer
Published 1997
| ISSN: |
1432-1211
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|---|---|
| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Biology
Medicine
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| Notes: |
Abstract  Immunoglobulin E responses to known environmental antigens (allergens) may serve as a general model to investigate germline genetic restriction of the immune response. We have previously shown genetic linkage between IgE responses to major allergens and the T-cell receptor (TCR) A/D locus, but not to TCR-B, implying that elements in TCR A/D restrict the ability to react to specific antigens. We now show, in two sets of subjects from the same population, a strong allelic association between a VA8.1 polymorphism (VA8.1 * 2) and reactivity to Der p II, a major antigenic component of the house dust mite Dermatophagoides pteronyssinus. Association was also seen between Der p II IgE titres and HLA-DRB1 * 1501 alleles. Reactivity to Der p II was confined to subjects who were positive for VA8.1 * 2 and HLA-DRB1 * 1501, demonstrating germline HLA-DR and TCR-A interaction in restricting the response to exogenous antigen.
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| Type of Medium: |
Electronic Resource
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| URL: |