Dipyridamole treatment in chronic obstructive airways disease: Effect on platelet regeneration time
Tremoli, E. ; Bertoli, L. ; Merlini, R. ; Colli, S. ; Maderna, P. ; Mantero, O. ; Sirtori, C. R.
Springer
Published 1982
Springer
Published 1982
| ISSN: |
1432-1041
|
|---|---|
| Keywords: |
chronic obstructive airways disease ; dipyridamole ; pulmonary thromboembolism ; platelet regeneration time
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| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Chemistry and Pharmacology
Medicine
|
| Notes: |
Summary The platelet regeneration time (PRT) determined in a group of hypoxaemic patients with chronic obstructive airways disease (COAD), before and after treatment with dipyridamole 150 mg tid, was compared with a group of control subjects. The PRT was computed by a modified non-radioisotope technique and was expressed as t1/2 in days. The patient group showed a significantly shortened PRT as compared to controls of the same age and sex (2.10±0.16 vs 3.65±0.26 days;p〈0.001). One month of dipyridamole administration resulted in prolongation of the PRT in COAD patients (2.10±0.16 days pre-treatment vs 2.75±0.20 post-treatment;p〈0.01), without affecting the platelet cyclo-oxygenase system. This study indicates that dipyridamole may be beneficial in pathological conditions, which are characterized by increased platelet turnover, possibly leading to frequent thromboembolic complications.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295565442744320 |
|---|---|
| autor | Tremoli, E. Bertoli, L. Merlini, R. Colli, S. Maderna, P. Mantero, O. Sirtori, C. R. |
| autorsonst | Tremoli, E. Bertoli, L. Merlini, R. Colli, S. Maderna, P. Mantero, O. Sirtori, C. R. |
| book_url | http://dx.doi.org/10.1007/BF00605992 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM202438260 |
| issn | 1432-1041 |
| journal_name | European journal of clinical pharmacology |
| materialart | 1 |
| notes | Summary The platelet regeneration time (PRT) determined in a group of hypoxaemic patients with chronic obstructive airways disease (COAD), before and after treatment with dipyridamole 150 mg tid, was compared with a group of control subjects. The PRT was computed by a modified non-radioisotope technique and was expressed as t1/2 in days. The patient group showed a significantly shortened PRT as compared to controls of the same age and sex (2.10±0.16 vs 3.65±0.26 days;p〈0.001). One month of dipyridamole administration resulted in prolongation of the PRT in COAD patients (2.10±0.16 days pre-treatment vs 2.75±0.20 post-treatment;p〈0.01), without affecting the platelet cyclo-oxygenase system. This study indicates that dipyridamole may be beneficial in pathological conditions, which are characterized by increased platelet turnover, possibly leading to frequent thromboembolic complications. |
| package_name | Springer |
| publikationsjahr_anzeige | 1982 |
| publikationsjahr_facette | 1982 |
| publikationsjahr_intervall | 8019:1980-1984 |
| publikationsjahr_sort | 1982 |
| publisher | Springer |
| reference | 23 (1982), S. 423-427 |
| schlagwort | chronic obstructive airways disease dipyridamole pulmonary thromboembolism platelet regeneration time |
| search_space | articles |
| shingle_author_1 | Tremoli, E. Bertoli, L. Merlini, R. Colli, S. Maderna, P. Mantero, O. Sirtori, C. R. |
| shingle_author_2 | Tremoli, E. Bertoli, L. Merlini, R. Colli, S. Maderna, P. Mantero, O. Sirtori, C. R. |
| shingle_author_3 | Tremoli, E. Bertoli, L. Merlini, R. Colli, S. Maderna, P. Mantero, O. Sirtori, C. R. |
| shingle_author_4 | Tremoli, E. Bertoli, L. Merlini, R. Colli, S. Maderna, P. Mantero, O. Sirtori, C. R. |
| shingle_catch_all_1 | Tremoli, E. Bertoli, L. Merlini, R. Colli, S. Maderna, P. Mantero, O. Sirtori, C. R. Dipyridamole treatment in chronic obstructive airways disease: Effect on platelet regeneration time chronic obstructive airways disease dipyridamole pulmonary thromboembolism platelet regeneration time chronic obstructive airways disease dipyridamole pulmonary thromboembolism platelet regeneration time Summary The platelet regeneration time (PRT) determined in a group of hypoxaemic patients with chronic obstructive airways disease (COAD), before and after treatment with dipyridamole 150 mg tid, was compared with a group of control subjects. The PRT was computed by a modified non-radioisotope technique and was expressed as t1/2 in days. The patient group showed a significantly shortened PRT as compared to controls of the same age and sex (2.10±0.16 vs 3.65±0.26 days;p〈0.001). One month of dipyridamole administration resulted in prolongation of the PRT in COAD patients (2.10±0.16 days pre-treatment vs 2.75±0.20 post-treatment;p〈0.01), without affecting the platelet cyclo-oxygenase system. This study indicates that dipyridamole may be beneficial in pathological conditions, which are characterized by increased platelet turnover, possibly leading to frequent thromboembolic complications. 1432-1041 14321041 Springer |
| shingle_catch_all_2 | Tremoli, E. Bertoli, L. Merlini, R. Colli, S. Maderna, P. Mantero, O. Sirtori, C. R. Dipyridamole treatment in chronic obstructive airways disease: Effect on platelet regeneration time chronic obstructive airways disease dipyridamole pulmonary thromboembolism platelet regeneration time chronic obstructive airways disease dipyridamole pulmonary thromboembolism platelet regeneration time Summary The platelet regeneration time (PRT) determined in a group of hypoxaemic patients with chronic obstructive airways disease (COAD), before and after treatment with dipyridamole 150 mg tid, was compared with a group of control subjects. The PRT was computed by a modified non-radioisotope technique and was expressed as t1/2 in days. The patient group showed a significantly shortened PRT as compared to controls of the same age and sex (2.10±0.16 vs 3.65±0.26 days;p〈0.001). One month of dipyridamole administration resulted in prolongation of the PRT in COAD patients (2.10±0.16 days pre-treatment vs 2.75±0.20 post-treatment;p〈0.01), without affecting the platelet cyclo-oxygenase system. This study indicates that dipyridamole may be beneficial in pathological conditions, which are characterized by increased platelet turnover, possibly leading to frequent thromboembolic complications. 1432-1041 14321041 Springer |
| shingle_catch_all_3 | Tremoli, E. Bertoli, L. Merlini, R. Colli, S. Maderna, P. Mantero, O. Sirtori, C. R. Dipyridamole treatment in chronic obstructive airways disease: Effect on platelet regeneration time chronic obstructive airways disease dipyridamole pulmonary thromboembolism platelet regeneration time chronic obstructive airways disease dipyridamole pulmonary thromboembolism platelet regeneration time Summary The platelet regeneration time (PRT) determined in a group of hypoxaemic patients with chronic obstructive airways disease (COAD), before and after treatment with dipyridamole 150 mg tid, was compared with a group of control subjects. The PRT was computed by a modified non-radioisotope technique and was expressed as t1/2 in days. The patient group showed a significantly shortened PRT as compared to controls of the same age and sex (2.10±0.16 vs 3.65±0.26 days;p〈0.001). One month of dipyridamole administration resulted in prolongation of the PRT in COAD patients (2.10±0.16 days pre-treatment vs 2.75±0.20 post-treatment;p〈0.01), without affecting the platelet cyclo-oxygenase system. This study indicates that dipyridamole may be beneficial in pathological conditions, which are characterized by increased platelet turnover, possibly leading to frequent thromboembolic complications. 1432-1041 14321041 Springer |
| shingle_catch_all_4 | Tremoli, E. Bertoli, L. Merlini, R. Colli, S. Maderna, P. Mantero, O. Sirtori, C. R. Dipyridamole treatment in chronic obstructive airways disease: Effect on platelet regeneration time chronic obstructive airways disease dipyridamole pulmonary thromboembolism platelet regeneration time chronic obstructive airways disease dipyridamole pulmonary thromboembolism platelet regeneration time Summary The platelet regeneration time (PRT) determined in a group of hypoxaemic patients with chronic obstructive airways disease (COAD), before and after treatment with dipyridamole 150 mg tid, was compared with a group of control subjects. The PRT was computed by a modified non-radioisotope technique and was expressed as t1/2 in days. The patient group showed a significantly shortened PRT as compared to controls of the same age and sex (2.10±0.16 vs 3.65±0.26 days;p〈0.001). One month of dipyridamole administration resulted in prolongation of the PRT in COAD patients (2.10±0.16 days pre-treatment vs 2.75±0.20 post-treatment;p〈0.01), without affecting the platelet cyclo-oxygenase system. This study indicates that dipyridamole may be beneficial in pathological conditions, which are characterized by increased platelet turnover, possibly leading to frequent thromboembolic complications. 1432-1041 14321041 Springer |
| shingle_title_1 | Dipyridamole treatment in chronic obstructive airways disease: Effect on platelet regeneration time |
| shingle_title_2 | Dipyridamole treatment in chronic obstructive airways disease: Effect on platelet regeneration time |
| shingle_title_3 | Dipyridamole treatment in chronic obstructive airways disease: Effect on platelet regeneration time |
| shingle_title_4 | Dipyridamole treatment in chronic obstructive airways disease: Effect on platelet regeneration time |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:38:13.877Z |
| titel | Dipyridamole treatment in chronic obstructive airways disease: Effect on platelet regeneration time |
| titel_suche | Dipyridamole treatment in chronic obstructive airways disease: Effect on platelet regeneration time |
| topic | V WW-YZ |
| uid | nat_lic_papers_NLM202438260 |