Dipyridamole treatment in chronic obstructive airways disease: Effect on platelet regeneration time
Tremoli, E. ; Bertoli, L. ; Merlini, R. ; Colli, S. ; Maderna, P. ; Mantero, O. ; Sirtori, C. R.
Springer
Published 1982
Springer
Published 1982
| ISSN: |
1432-1041
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|---|---|
| Keywords: |
chronic obstructive airways disease ; dipyridamole ; pulmonary thromboembolism ; platelet regeneration time
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Chemistry and Pharmacology
Medicine
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| Notes: |
Summary The platelet regeneration time (PRT) determined in a group of hypoxaemic patients with chronic obstructive airways disease (COAD), before and after treatment with dipyridamole 150 mg tid, was compared with a group of control subjects. The PRT was computed by a modified non-radioisotope technique and was expressed as t1/2 in days. The patient group showed a significantly shortened PRT as compared to controls of the same age and sex (2.10±0.16 vs 3.65±0.26 days;p〈0.001). One month of dipyridamole administration resulted in prolongation of the PRT in COAD patients (2.10±0.16 days pre-treatment vs 2.75±0.20 post-treatment;p〈0.01), without affecting the platelet cyclo-oxygenase system. This study indicates that dipyridamole may be beneficial in pathological conditions, which are characterized by increased platelet turnover, possibly leading to frequent thromboembolic complications.
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| Type of Medium: |
Electronic Resource
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| URL: |