Kinetics and efficacy of theophylline in the treatment of apnea in the premature newborn
Latini, R. ; Assael, B. M. ; Bonati, M. ; Caccamo, M. L. ; Gerna, M. ; Mandelli, M. ; Marini, A. ; Sereni, F. ; Tognoni, G.
Springer
Published 1978
Springer
Published 1978
| ISSN: |
1432-1041
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|---|---|
| Keywords: |
Theophylline ; kinetics ; apnea ; premature newborns ; developmental pharmacology
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Chemistry and Pharmacology
Medicine
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| Notes: |
Summary Aminophylline (theophylline-ethylenediamine) was administered to 27 premature newborns to prevent apneic spells. Of the 22 patients monitored for theophylline concentration, a therapeutic blood level was reached in 19 in 1–2 days, and 3 stayed below it. ‘Toxic’ blood levels (≥20 µg/ml) were reached in 3 cases, one of whom showed signs of toxicity. Theophylline treatment was not efficient in the prevention of apnea when a serious underlying disease was present. Theophylline blood half-life (mean : 27.0 h) and clearance (mean 12.9 ml/h/kg) confirmed the slow elimination pattern of the drug in the premature infant.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295564698255360 |
|---|---|
| autor | Latini, R. Assael, B. M. Bonati, M. Caccamo, M. L. Gerna, M. Mandelli, M. Marini, A. Sereni, F. Tognoni, G. |
| autorsonst | Latini, R. Assael, B. M. Bonati, M. Caccamo, M. L. Gerna, M. Mandelli, M. Marini, A. Sereni, F. Tognoni, G. |
| book_url | http://dx.doi.org/10.1007/BF00609983 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM202429199 |
| issn | 1432-1041 |
| journal_name | European journal of clinical pharmacology |
| materialart | 1 |
| notes | Summary Aminophylline (theophylline-ethylenediamine) was administered to 27 premature newborns to prevent apneic spells. Of the 22 patients monitored for theophylline concentration, a therapeutic blood level was reached in 19 in 1–2 days, and 3 stayed below it. ‘Toxic’ blood levels (≥20 µg/ml) were reached in 3 cases, one of whom showed signs of toxicity. Theophylline treatment was not efficient in the prevention of apnea when a serious underlying disease was present. Theophylline blood half-life (mean : 27.0 h) and clearance (mean 12.9 ml/h/kg) confirmed the slow elimination pattern of the drug in the premature infant. |
| package_name | Springer |
| publikationsjahr_anzeige | 1978 |
| publikationsjahr_facette | 1978 |
| publikationsjahr_intervall | 8024:1975-1979 |
| publikationsjahr_sort | 1978 |
| publisher | Springer |
| reference | 13 (1978), S. 203-207 |
| schlagwort | Theophylline kinetics apnea premature newborns developmental pharmacology |
| search_space | articles |
| shingle_author_1 | Latini, R. Assael, B. M. Bonati, M. Caccamo, M. L. Gerna, M. Mandelli, M. Marini, A. Sereni, F. Tognoni, G. |
| shingle_author_2 | Latini, R. Assael, B. M. Bonati, M. Caccamo, M. L. Gerna, M. Mandelli, M. Marini, A. Sereni, F. Tognoni, G. |
| shingle_author_3 | Latini, R. Assael, B. M. Bonati, M. Caccamo, M. L. Gerna, M. Mandelli, M. Marini, A. Sereni, F. Tognoni, G. |
| shingle_author_4 | Latini, R. Assael, B. M. Bonati, M. Caccamo, M. L. Gerna, M. Mandelli, M. Marini, A. Sereni, F. Tognoni, G. |
| shingle_catch_all_1 | Latini, R. Assael, B. M. Bonati, M. Caccamo, M. L. Gerna, M. Mandelli, M. Marini, A. Sereni, F. Tognoni, G. Kinetics and efficacy of theophylline in the treatment of apnea in the premature newborn Theophylline kinetics apnea premature newborns developmental pharmacology Theophylline kinetics apnea premature newborns developmental pharmacology Summary Aminophylline (theophylline-ethylenediamine) was administered to 27 premature newborns to prevent apneic spells. Of the 22 patients monitored for theophylline concentration, a therapeutic blood level was reached in 19 in 1–2 days, and 3 stayed below it. ‘Toxic’ blood levels (≥20 µg/ml) were reached in 3 cases, one of whom showed signs of toxicity. Theophylline treatment was not efficient in the prevention of apnea when a serious underlying disease was present. Theophylline blood half-life (mean : 27.0 h) and clearance (mean 12.9 ml/h/kg) confirmed the slow elimination pattern of the drug in the premature infant. 1432-1041 14321041 Springer |
| shingle_catch_all_2 | Latini, R. Assael, B. M. Bonati, M. Caccamo, M. L. Gerna, M. Mandelli, M. Marini, A. Sereni, F. Tognoni, G. Kinetics and efficacy of theophylline in the treatment of apnea in the premature newborn Theophylline kinetics apnea premature newborns developmental pharmacology Theophylline kinetics apnea premature newborns developmental pharmacology Summary Aminophylline (theophylline-ethylenediamine) was administered to 27 premature newborns to prevent apneic spells. Of the 22 patients monitored for theophylline concentration, a therapeutic blood level was reached in 19 in 1–2 days, and 3 stayed below it. ‘Toxic’ blood levels (≥20 µg/ml) were reached in 3 cases, one of whom showed signs of toxicity. Theophylline treatment was not efficient in the prevention of apnea when a serious underlying disease was present. Theophylline blood half-life (mean : 27.0 h) and clearance (mean 12.9 ml/h/kg) confirmed the slow elimination pattern of the drug in the premature infant. 1432-1041 14321041 Springer |
| shingle_catch_all_3 | Latini, R. Assael, B. M. Bonati, M. Caccamo, M. L. Gerna, M. Mandelli, M. Marini, A. Sereni, F. Tognoni, G. Kinetics and efficacy of theophylline in the treatment of apnea in the premature newborn Theophylline kinetics apnea premature newborns developmental pharmacology Theophylline kinetics apnea premature newborns developmental pharmacology Summary Aminophylline (theophylline-ethylenediamine) was administered to 27 premature newborns to prevent apneic spells. Of the 22 patients monitored for theophylline concentration, a therapeutic blood level was reached in 19 in 1–2 days, and 3 stayed below it. ‘Toxic’ blood levels (≥20 µg/ml) were reached in 3 cases, one of whom showed signs of toxicity. Theophylline treatment was not efficient in the prevention of apnea when a serious underlying disease was present. Theophylline blood half-life (mean : 27.0 h) and clearance (mean 12.9 ml/h/kg) confirmed the slow elimination pattern of the drug in the premature infant. 1432-1041 14321041 Springer |
| shingle_catch_all_4 | Latini, R. Assael, B. M. Bonati, M. Caccamo, M. L. Gerna, M. Mandelli, M. Marini, A. Sereni, F. Tognoni, G. Kinetics and efficacy of theophylline in the treatment of apnea in the premature newborn Theophylline kinetics apnea premature newborns developmental pharmacology Theophylline kinetics apnea premature newborns developmental pharmacology Summary Aminophylline (theophylline-ethylenediamine) was administered to 27 premature newborns to prevent apneic spells. Of the 22 patients monitored for theophylline concentration, a therapeutic blood level was reached in 19 in 1–2 days, and 3 stayed below it. ‘Toxic’ blood levels (≥20 µg/ml) were reached in 3 cases, one of whom showed signs of toxicity. Theophylline treatment was not efficient in the prevention of apnea when a serious underlying disease was present. Theophylline blood half-life (mean : 27.0 h) and clearance (mean 12.9 ml/h/kg) confirmed the slow elimination pattern of the drug in the premature infant. 1432-1041 14321041 Springer |
| shingle_title_1 | Kinetics and efficacy of theophylline in the treatment of apnea in the premature newborn |
| shingle_title_2 | Kinetics and efficacy of theophylline in the treatment of apnea in the premature newborn |
| shingle_title_3 | Kinetics and efficacy of theophylline in the treatment of apnea in the premature newborn |
| shingle_title_4 | Kinetics and efficacy of theophylline in the treatment of apnea in the premature newborn |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:38:12.780Z |
| titel | Kinetics and efficacy of theophylline in the treatment of apnea in the premature newborn |
| titel_suche | Kinetics and efficacy of theophylline in the treatment of apnea in the premature newborn |
| topic | V WW-YZ |
| uid | nat_lic_papers_NLM202429199 |