Kinetics and efficacy of theophylline in the treatment of apnea in the premature newborn
Latini, R. ; Assael, B. M. ; Bonati, M. ; Caccamo, M. L. ; Gerna, M. ; Mandelli, M. ; Marini, A. ; Sereni, F. ; Tognoni, G.
Springer
Published 1978
Springer
Published 1978
| ISSN: |
1432-1041
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| Keywords: |
Theophylline ; kinetics ; apnea ; premature newborns ; developmental pharmacology
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Chemistry and Pharmacology
Medicine
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| Notes: |
Summary Aminophylline (theophylline-ethylenediamine) was administered to 27 premature newborns to prevent apneic spells. Of the 22 patients monitored for theophylline concentration, a therapeutic blood level was reached in 19 in 1–2 days, and 3 stayed below it. ‘Toxic’ blood levels (≥20 µg/ml) were reached in 3 cases, one of whom showed signs of toxicity. Theophylline treatment was not efficient in the prevention of apnea when a serious underlying disease was present. Theophylline blood half-life (mean : 27.0 h) and clearance (mean 12.9 ml/h/kg) confirmed the slow elimination pattern of the drug in the premature infant.
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| Type of Medium: |
Electronic Resource
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| URL: |