Increased presence of common systemic lupus erythematosus (SLE) anti-DNA idiotypes (16/6 Id, 32/15 Id) is induced by procainamide
Shoenfeld, Yehuda ; Vilner, Yaffa ; Reshef, Tami ; Klajman, Abraham ; Skibin, A. ; Kooperman, O. ; Kennedy, R. C.
Springer
Published 1987
Springer
Published 1987
| ISSN: |
1573-2592
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|---|---|
| Keywords: |
Anti-DNA antibodies ; systemic lupus erythematosus ; drug-induced lupus ; autoimmunity ; idiotypes ; procainamide ; antihistone antibodies
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract Sixty-seven patients on treatment with procainamide were examined for the presence of two common idiotypes of anti-DNA antibodies (16/6 Id and 32/15 Id). These idiotypes have been shown previously to have clinical relevance in patients with systemic lupus erythematosus (SLE). An enzyme-linked immunosorbent assay (ELISA) with rabbit anti-Id antibodies revealed increased concentrations of the 16/6 Id and 32/15 Id in 25 (37%) and 16 (24%) patients, respectively. Five of eight patients with drug-induced lupus had elevated titers of both idiotypes. A high correlation (R=0.56,P〈0.001 for 16/6 Id) was found between Id levels and anti-single-stranded DNA (ssDNA) antibody titers and between 16/6 Id titers and antihistone antibodies (IgG,R=0.43; IgM,R=0.25). It seems that procainamide, a component known to be associated with drug-induced lupus, may induce an increased production of common anti-DNA idiotypes in apparently normal subjects.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798296648606023681 |
|---|---|
| autor | Shoenfeld, Yehuda Vilner, Yaffa Reshef, Tami Klajman, Abraham Skibin, A. Kooperman, O. Kennedy, R. C. |
| autorsonst | Shoenfeld, Yehuda Vilner, Yaffa Reshef, Tami Klajman, Abraham Skibin, A. Kooperman, O. Kennedy, R. C. |
| book_url | http://dx.doi.org/10.1007/BF00917019 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM197591671 |
| issn | 1573-2592 |
| journal_name | Journal of clinical immunology |
| materialart | 1 |
| notes | Abstract Sixty-seven patients on treatment with procainamide were examined for the presence of two common idiotypes of anti-DNA antibodies (16/6 Id and 32/15 Id). These idiotypes have been shown previously to have clinical relevance in patients with systemic lupus erythematosus (SLE). An enzyme-linked immunosorbent assay (ELISA) with rabbit anti-Id antibodies revealed increased concentrations of the 16/6 Id and 32/15 Id in 25 (37%) and 16 (24%) patients, respectively. Five of eight patients with drug-induced lupus had elevated titers of both idiotypes. A high correlation (R=0.56,P〈0.001 for 16/6 Id) was found between Id levels and anti-single-stranded DNA (ssDNA) antibody titers and between 16/6 Id titers and antihistone antibodies (IgG,R=0.43; IgM,R=0.25). It seems that procainamide, a component known to be associated with drug-induced lupus, may induce an increased production of common anti-DNA idiotypes in apparently normal subjects. |
| package_name | Springer |
| publikationsjahr_anzeige | 1987 |
| publikationsjahr_facette | 1987 |
| publikationsjahr_intervall | 8014:1985-1989 |
| publikationsjahr_sort | 1987 |
| publisher | Springer |
| reference | 7 (1987), S. 410-419 |
| schlagwort | Anti-DNA antibodies systemic lupus erythematosus drug-induced lupus autoimmunity idiotypes procainamide antihistone antibodies |
| search_space | articles |
| shingle_author_1 | Shoenfeld, Yehuda Vilner, Yaffa Reshef, Tami Klajman, Abraham Skibin, A. Kooperman, O. Kennedy, R. C. |
| shingle_author_2 | Shoenfeld, Yehuda Vilner, Yaffa Reshef, Tami Klajman, Abraham Skibin, A. Kooperman, O. Kennedy, R. C. |
| shingle_author_3 | Shoenfeld, Yehuda Vilner, Yaffa Reshef, Tami Klajman, Abraham Skibin, A. Kooperman, O. Kennedy, R. C. |
| shingle_author_4 | Shoenfeld, Yehuda Vilner, Yaffa Reshef, Tami Klajman, Abraham Skibin, A. Kooperman, O. Kennedy, R. C. |
| shingle_catch_all_1 | Shoenfeld, Yehuda Vilner, Yaffa Reshef, Tami Klajman, Abraham Skibin, A. Kooperman, O. Kennedy, R. C. Increased presence of common systemic lupus erythematosus (SLE) anti-DNA idiotypes (16/6 Id, 32/15 Id) is induced by procainamide Anti-DNA antibodies systemic lupus erythematosus drug-induced lupus autoimmunity idiotypes procainamide antihistone antibodies Anti-DNA antibodies systemic lupus erythematosus drug-induced lupus autoimmunity idiotypes procainamide antihistone antibodies Abstract Sixty-seven patients on treatment with procainamide were examined for the presence of two common idiotypes of anti-DNA antibodies (16/6 Id and 32/15 Id). These idiotypes have been shown previously to have clinical relevance in patients with systemic lupus erythematosus (SLE). An enzyme-linked immunosorbent assay (ELISA) with rabbit anti-Id antibodies revealed increased concentrations of the 16/6 Id and 32/15 Id in 25 (37%) and 16 (24%) patients, respectively. Five of eight patients with drug-induced lupus had elevated titers of both idiotypes. A high correlation (R=0.56,P〈0.001 for 16/6 Id) was found between Id levels and anti-single-stranded DNA (ssDNA) antibody titers and between 16/6 Id titers and antihistone antibodies (IgG,R=0.43; IgM,R=0.25). It seems that procainamide, a component known to be associated with drug-induced lupus, may induce an increased production of common anti-DNA idiotypes in apparently normal subjects. 1573-2592 15732592 Springer |
| shingle_catch_all_2 | Shoenfeld, Yehuda Vilner, Yaffa Reshef, Tami Klajman, Abraham Skibin, A. Kooperman, O. Kennedy, R. C. Increased presence of common systemic lupus erythematosus (SLE) anti-DNA idiotypes (16/6 Id, 32/15 Id) is induced by procainamide Anti-DNA antibodies systemic lupus erythematosus drug-induced lupus autoimmunity idiotypes procainamide antihistone antibodies Anti-DNA antibodies systemic lupus erythematosus drug-induced lupus autoimmunity idiotypes procainamide antihistone antibodies Abstract Sixty-seven patients on treatment with procainamide were examined for the presence of two common idiotypes of anti-DNA antibodies (16/6 Id and 32/15 Id). These idiotypes have been shown previously to have clinical relevance in patients with systemic lupus erythematosus (SLE). An enzyme-linked immunosorbent assay (ELISA) with rabbit anti-Id antibodies revealed increased concentrations of the 16/6 Id and 32/15 Id in 25 (37%) and 16 (24%) patients, respectively. Five of eight patients with drug-induced lupus had elevated titers of both idiotypes. A high correlation (R=0.56,P〈0.001 for 16/6 Id) was found between Id levels and anti-single-stranded DNA (ssDNA) antibody titers and between 16/6 Id titers and antihistone antibodies (IgG,R=0.43; IgM,R=0.25). It seems that procainamide, a component known to be associated with drug-induced lupus, may induce an increased production of common anti-DNA idiotypes in apparently normal subjects. 1573-2592 15732592 Springer |
| shingle_catch_all_3 | Shoenfeld, Yehuda Vilner, Yaffa Reshef, Tami Klajman, Abraham Skibin, A. Kooperman, O. Kennedy, R. C. Increased presence of common systemic lupus erythematosus (SLE) anti-DNA idiotypes (16/6 Id, 32/15 Id) is induced by procainamide Anti-DNA antibodies systemic lupus erythematosus drug-induced lupus autoimmunity idiotypes procainamide antihistone antibodies Anti-DNA antibodies systemic lupus erythematosus drug-induced lupus autoimmunity idiotypes procainamide antihistone antibodies Abstract Sixty-seven patients on treatment with procainamide were examined for the presence of two common idiotypes of anti-DNA antibodies (16/6 Id and 32/15 Id). These idiotypes have been shown previously to have clinical relevance in patients with systemic lupus erythematosus (SLE). An enzyme-linked immunosorbent assay (ELISA) with rabbit anti-Id antibodies revealed increased concentrations of the 16/6 Id and 32/15 Id in 25 (37%) and 16 (24%) patients, respectively. Five of eight patients with drug-induced lupus had elevated titers of both idiotypes. A high correlation (R=0.56,P〈0.001 for 16/6 Id) was found between Id levels and anti-single-stranded DNA (ssDNA) antibody titers and between 16/6 Id titers and antihistone antibodies (IgG,R=0.43; IgM,R=0.25). It seems that procainamide, a component known to be associated with drug-induced lupus, may induce an increased production of common anti-DNA idiotypes in apparently normal subjects. 1573-2592 15732592 Springer |
| shingle_catch_all_4 | Shoenfeld, Yehuda Vilner, Yaffa Reshef, Tami Klajman, Abraham Skibin, A. Kooperman, O. Kennedy, R. C. Increased presence of common systemic lupus erythematosus (SLE) anti-DNA idiotypes (16/6 Id, 32/15 Id) is induced by procainamide Anti-DNA antibodies systemic lupus erythematosus drug-induced lupus autoimmunity idiotypes procainamide antihistone antibodies Anti-DNA antibodies systemic lupus erythematosus drug-induced lupus autoimmunity idiotypes procainamide antihistone antibodies Abstract Sixty-seven patients on treatment with procainamide were examined for the presence of two common idiotypes of anti-DNA antibodies (16/6 Id and 32/15 Id). These idiotypes have been shown previously to have clinical relevance in patients with systemic lupus erythematosus (SLE). An enzyme-linked immunosorbent assay (ELISA) with rabbit anti-Id antibodies revealed increased concentrations of the 16/6 Id and 32/15 Id in 25 (37%) and 16 (24%) patients, respectively. Five of eight patients with drug-induced lupus had elevated titers of both idiotypes. A high correlation (R=0.56,P〈0.001 for 16/6 Id) was found between Id levels and anti-single-stranded DNA (ssDNA) antibody titers and between 16/6 Id titers and antihistone antibodies (IgG,R=0.43; IgM,R=0.25). It seems that procainamide, a component known to be associated with drug-induced lupus, may induce an increased production of common anti-DNA idiotypes in apparently normal subjects. 1573-2592 15732592 Springer |
| shingle_title_1 | Increased presence of common systemic lupus erythematosus (SLE) anti-DNA idiotypes (16/6 Id, 32/15 Id) is induced by procainamide |
| shingle_title_2 | Increased presence of common systemic lupus erythematosus (SLE) anti-DNA idiotypes (16/6 Id, 32/15 Id) is induced by procainamide |
| shingle_title_3 | Increased presence of common systemic lupus erythematosus (SLE) anti-DNA idiotypes (16/6 Id, 32/15 Id) is induced by procainamide |
| shingle_title_4 | Increased presence of common systemic lupus erythematosus (SLE) anti-DNA idiotypes (16/6 Id, 32/15 Id) is induced by procainamide |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:55:26.833Z |
| titel | Increased presence of common systemic lupus erythematosus (SLE) anti-DNA idiotypes (16/6 Id, 32/15 Id) is induced by procainamide |
| titel_suche | Increased presence of common systemic lupus erythematosus (SLE) anti-DNA idiotypes (16/6 Id, 32/15 Id) is induced by procainamide |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM197591671 |