Increased presence of common systemic lupus erythematosus (SLE) anti-DNA idiotypes (16/6 Id, 32/15 Id) is induced by procainamide
Shoenfeld, Yehuda ; Vilner, Yaffa ; Reshef, Tami ; Klajman, Abraham ; Skibin, A. ; Kooperman, O. ; Kennedy, R. C.
Springer
Published 1987
Springer
Published 1987
| ISSN: |
1573-2592
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| Keywords: |
Anti-DNA antibodies ; systemic lupus erythematosus ; drug-induced lupus ; autoimmunity ; idiotypes ; procainamide ; antihistone antibodies
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract Sixty-seven patients on treatment with procainamide were examined for the presence of two common idiotypes of anti-DNA antibodies (16/6 Id and 32/15 Id). These idiotypes have been shown previously to have clinical relevance in patients with systemic lupus erythematosus (SLE). An enzyme-linked immunosorbent assay (ELISA) with rabbit anti-Id antibodies revealed increased concentrations of the 16/6 Id and 32/15 Id in 25 (37%) and 16 (24%) patients, respectively. Five of eight patients with drug-induced lupus had elevated titers of both idiotypes. A high correlation (R=0.56,P〈0.001 for 16/6 Id) was found between Id levels and anti-single-stranded DNA (ssDNA) antibody titers and between 16/6 Id titers and antihistone antibodies (IgG,R=0.43; IgM,R=0.25). It seems that procainamide, a component known to be associated with drug-induced lupus, may induce an increased production of common anti-DNA idiotypes in apparently normal subjects.
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| Type of Medium: |
Electronic Resource
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| URL: |