Failure to control AIDS-related CMV-retinitis with intravenous ganciclovir
Bernauer, Wolfgang ; Meyer, Peter ; Zimmerli, Werner ; Daicker, Basil ; Ruettimann, Sigmund
Springer
Published 1992
Springer
Published 1992
| ISSN: |
1573-2630
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|---|---|
| Keywords: |
cytomegalovirus ; retinitis ; ganciclovir (DHPG) ; treatment failure ; resistance ; virustatic drug ; AIDS-patients
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| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Medicine
|
| Notes: |
Abstract Between January 1988 and May 1991 intravenous ganciclovir (GCV) treatment was administered to eight male AIDS-patients with unilateral cytomegalovirus(CMV)-retinitis. Despite of continuous therapy with at least the recommended dose of GCV, three patients developed slowly progressive CMV-retinitis in the fellow eye after 4 to 13 months. The progression could not be stopped by GCV and thus bilateral blindness resulted after 12 to 22 months. The number of CD4-lymphocytes in the blood was reduced in all patients, but particularly in patients with progressive disease. Treatment failure was partly related to the duration of CMV-retinitis and partly to the degree of immunodeficiency. Intravenous treatment with GCV alone can not stop the progression of CMV-retinitis in long-term survivors and in those with advanced immunodeficiency.
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798296653883506689 |
|---|---|
| autor | Bernauer, Wolfgang Meyer, Peter Zimmerli, Werner Daicker, Basil Ruettimann, Sigmund |
| autorsonst | Bernauer, Wolfgang Meyer, Peter Zimmerli, Werner Daicker, Basil Ruettimann, Sigmund |
| book_url | http://dx.doi.org/10.1007/BF00918436 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM194444708 |
| issn | 1573-2630 |
| journal_name | International ophthalmology |
| materialart | 1 |
| notes | Abstract Between January 1988 and May 1991 intravenous ganciclovir (GCV) treatment was administered to eight male AIDS-patients with unilateral cytomegalovirus(CMV)-retinitis. Despite of continuous therapy with at least the recommended dose of GCV, three patients developed slowly progressive CMV-retinitis in the fellow eye after 4 to 13 months. The progression could not be stopped by GCV and thus bilateral blindness resulted after 12 to 22 months. The number of CD4-lymphocytes in the blood was reduced in all patients, but particularly in patients with progressive disease. Treatment failure was partly related to the duration of CMV-retinitis and partly to the degree of immunodeficiency. Intravenous treatment with GCV alone can not stop the progression of CMV-retinitis in long-term survivors and in those with advanced immunodeficiency. |
| package_name | Springer |
| publikationsjahr_anzeige | 1992 |
| publikationsjahr_facette | 1992 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1992 |
| publisher | Springer |
| reference | 16 (1992), S. 453-457 |
| schlagwort | cytomegalovirus retinitis ganciclovir (DHPG) treatment failure resistance virustatic drug AIDS-patients |
| search_space | articles |
| shingle_author_1 | Bernauer, Wolfgang Meyer, Peter Zimmerli, Werner Daicker, Basil Ruettimann, Sigmund |
| shingle_author_2 | Bernauer, Wolfgang Meyer, Peter Zimmerli, Werner Daicker, Basil Ruettimann, Sigmund |
| shingle_author_3 | Bernauer, Wolfgang Meyer, Peter Zimmerli, Werner Daicker, Basil Ruettimann, Sigmund |
| shingle_author_4 | Bernauer, Wolfgang Meyer, Peter Zimmerli, Werner Daicker, Basil Ruettimann, Sigmund |
| shingle_catch_all_1 | Bernauer, Wolfgang Meyer, Peter Zimmerli, Werner Daicker, Basil Ruettimann, Sigmund Failure to control AIDS-related CMV-retinitis with intravenous ganciclovir cytomegalovirus retinitis ganciclovir (DHPG) treatment failure resistance virustatic drug AIDS-patients cytomegalovirus retinitis ganciclovir (DHPG) treatment failure resistance virustatic drug AIDS-patients Abstract Between January 1988 and May 1991 intravenous ganciclovir (GCV) treatment was administered to eight male AIDS-patients with unilateral cytomegalovirus(CMV)-retinitis. Despite of continuous therapy with at least the recommended dose of GCV, three patients developed slowly progressive CMV-retinitis in the fellow eye after 4 to 13 months. The progression could not be stopped by GCV and thus bilateral blindness resulted after 12 to 22 months. The number of CD4-lymphocytes in the blood was reduced in all patients, but particularly in patients with progressive disease. Treatment failure was partly related to the duration of CMV-retinitis and partly to the degree of immunodeficiency. Intravenous treatment with GCV alone can not stop the progression of CMV-retinitis in long-term survivors and in those with advanced immunodeficiency. 1573-2630 15732630 Springer |
| shingle_catch_all_2 | Bernauer, Wolfgang Meyer, Peter Zimmerli, Werner Daicker, Basil Ruettimann, Sigmund Failure to control AIDS-related CMV-retinitis with intravenous ganciclovir cytomegalovirus retinitis ganciclovir (DHPG) treatment failure resistance virustatic drug AIDS-patients cytomegalovirus retinitis ganciclovir (DHPG) treatment failure resistance virustatic drug AIDS-patients Abstract Between January 1988 and May 1991 intravenous ganciclovir (GCV) treatment was administered to eight male AIDS-patients with unilateral cytomegalovirus(CMV)-retinitis. Despite of continuous therapy with at least the recommended dose of GCV, three patients developed slowly progressive CMV-retinitis in the fellow eye after 4 to 13 months. The progression could not be stopped by GCV and thus bilateral blindness resulted after 12 to 22 months. The number of CD4-lymphocytes in the blood was reduced in all patients, but particularly in patients with progressive disease. Treatment failure was partly related to the duration of CMV-retinitis and partly to the degree of immunodeficiency. Intravenous treatment with GCV alone can not stop the progression of CMV-retinitis in long-term survivors and in those with advanced immunodeficiency. 1573-2630 15732630 Springer |
| shingle_catch_all_3 | Bernauer, Wolfgang Meyer, Peter Zimmerli, Werner Daicker, Basil Ruettimann, Sigmund Failure to control AIDS-related CMV-retinitis with intravenous ganciclovir cytomegalovirus retinitis ganciclovir (DHPG) treatment failure resistance virustatic drug AIDS-patients cytomegalovirus retinitis ganciclovir (DHPG) treatment failure resistance virustatic drug AIDS-patients Abstract Between January 1988 and May 1991 intravenous ganciclovir (GCV) treatment was administered to eight male AIDS-patients with unilateral cytomegalovirus(CMV)-retinitis. Despite of continuous therapy with at least the recommended dose of GCV, three patients developed slowly progressive CMV-retinitis in the fellow eye after 4 to 13 months. The progression could not be stopped by GCV and thus bilateral blindness resulted after 12 to 22 months. The number of CD4-lymphocytes in the blood was reduced in all patients, but particularly in patients with progressive disease. Treatment failure was partly related to the duration of CMV-retinitis and partly to the degree of immunodeficiency. Intravenous treatment with GCV alone can not stop the progression of CMV-retinitis in long-term survivors and in those with advanced immunodeficiency. 1573-2630 15732630 Springer |
| shingle_catch_all_4 | Bernauer, Wolfgang Meyer, Peter Zimmerli, Werner Daicker, Basil Ruettimann, Sigmund Failure to control AIDS-related CMV-retinitis with intravenous ganciclovir cytomegalovirus retinitis ganciclovir (DHPG) treatment failure resistance virustatic drug AIDS-patients cytomegalovirus retinitis ganciclovir (DHPG) treatment failure resistance virustatic drug AIDS-patients Abstract Between January 1988 and May 1991 intravenous ganciclovir (GCV) treatment was administered to eight male AIDS-patients with unilateral cytomegalovirus(CMV)-retinitis. Despite of continuous therapy with at least the recommended dose of GCV, three patients developed slowly progressive CMV-retinitis in the fellow eye after 4 to 13 months. The progression could not be stopped by GCV and thus bilateral blindness resulted after 12 to 22 months. The number of CD4-lymphocytes in the blood was reduced in all patients, but particularly in patients with progressive disease. Treatment failure was partly related to the duration of CMV-retinitis and partly to the degree of immunodeficiency. Intravenous treatment with GCV alone can not stop the progression of CMV-retinitis in long-term survivors and in those with advanced immunodeficiency. 1573-2630 15732630 Springer |
| shingle_title_1 | Failure to control AIDS-related CMV-retinitis with intravenous ganciclovir |
| shingle_title_2 | Failure to control AIDS-related CMV-retinitis with intravenous ganciclovir |
| shingle_title_3 | Failure to control AIDS-related CMV-retinitis with intravenous ganciclovir |
| shingle_title_4 | Failure to control AIDS-related CMV-retinitis with intravenous ganciclovir |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:55:31.938Z |
| titel | Failure to control AIDS-related CMV-retinitis with intravenous ganciclovir |
| titel_suche | Failure to control AIDS-related CMV-retinitis with intravenous ganciclovir |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM194444708 |