Failure to control AIDS-related CMV-retinitis with intravenous ganciclovir
Bernauer, Wolfgang ; Meyer, Peter ; Zimmerli, Werner ; Daicker, Basil ; Ruettimann, Sigmund
Springer
Published 1992
Springer
Published 1992
| ISSN: |
1573-2630
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|---|---|
| Keywords: |
cytomegalovirus ; retinitis ; ganciclovir (DHPG) ; treatment failure ; resistance ; virustatic drug ; AIDS-patients
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract Between January 1988 and May 1991 intravenous ganciclovir (GCV) treatment was administered to eight male AIDS-patients with unilateral cytomegalovirus(CMV)-retinitis. Despite of continuous therapy with at least the recommended dose of GCV, three patients developed slowly progressive CMV-retinitis in the fellow eye after 4 to 13 months. The progression could not be stopped by GCV and thus bilateral blindness resulted after 12 to 22 months. The number of CD4-lymphocytes in the blood was reduced in all patients, but particularly in patients with progressive disease. Treatment failure was partly related to the duration of CMV-retinitis and partly to the degree of immunodeficiency. Intravenous treatment with GCV alone can not stop the progression of CMV-retinitis in long-term survivors and in those with advanced immunodeficiency.
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| Type of Medium: |
Electronic Resource
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| URL: |