Liposome-bound cyclosporine: Clearance after intravitreal injection
Alghadyan, Abdulrahman A. ; Peyman, Gholam A. ; Khoobehi, Bahram ; Milner, Steve ; Liu, Kwan-Rong
Springer
Published 1988
Springer
Published 1988
| ISSN: |
1573-2630
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|---|---|
| Keywords: |
aqueous ; cyclosporine ; HPLC ; liposome ; rabbit ; vitreous
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract The concentration of cyclosporine in the vitreous after intravitreal injection of 100 micrograms of either free or liposome-bound cyclosporine was studied in albino rabbits. We found that the half-life of free cyclosporine was about 6 hours and that of liposome-bound cyclosporine was about 3 days. The finding indicates that liposome-bound cyclosporine prolongs the availability of the drug.
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| Type of Medium: |
Electronic Resource
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| URL: |