Liposome-bound cyclosporine: Aqueous and vitreous level after subconjunctival injection
Alghadyan, Abdulrahman A. ; Peyman, Gholam A. ; Khoobehi, Bahram ; Milner, Steve ; Liu, K. R.
Springer
Published 1988
Springer
Published 1988
| ISSN: |
1573-2630
|
|---|---|
| Keywords: |
aqueous ; cyclosporine ; HPLC ; liposome ; rabbit ; vitreous
|
| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Medicine
|
| Notes: |
Abstract The concentration of cyclosporine in the aqueous and vitreous humors of albino rabbits was measured, using HPLC at intervals of 24, 48, 96, and 192 hours after subconjunctival injections of 2.5 mg of free or liposome-bound cyclosporine. The aqueous concentration was reasonably high in both groups until day 4: 1050 nanograms per milliliter in the group receiving free cyclosporine, and 1438 nanograms per milliliter in the group receiving liposome-bound cyclosporine. The vitreous concentration was very low in both groups.
|
| Type of Medium: |
Electronic Resource
|
| URL: |