Inhibitory effect of econazole on the release of thromboxanes
Jancar, S. ; Teixeira, C. F. P. ; Tavares de Lima, W. ; Hoshikawa Fujimura, A. Y. ; Sirois, P.
Springer
Published 1991
Springer
Published 1991
| ISSN: |
1420-908X
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|---|---|
| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract The effect of econazole on the release of thromboxanes was investigated. It was found that econazole inhibited concentration-dependently the aggregation of guinea pig platelets stimulated with arachidonic acid. The compound also reduced significantly the LTB4-induced contraction of guinea pig lung parenchyma strips and the contraction of rabbit aorta to the effluent of LTD4-stimulated guinea pig lungs, both effects mediated mostly by thromboxane generation. The concentration of TXB2 in the effluents from LTD4 stimulated lungs, assayed by EIA, was significantly reduced following pretreatment of the lungs with 10−4 M and 10−5 M of econazole, whereas the levels of PGE2 were increased. These results demonstrate that econazole is a selective inhibitor of thromboxane synthesis.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295353906167808 |
|---|---|
| autor | Jancar, S. Teixeira, C. F. P. Tavares de Lima, W. Hoshikawa Fujimura, A. Y. Sirois, P. |
| autorsonst | Jancar, S. Teixeira, C. F. P. Tavares de Lima, W. Hoshikawa Fujimura, A. Y. Sirois, P. |
| book_url | http://dx.doi.org/10.1007/BF01988733 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM18911097X |
| issn | 1420-908X |
| journal_name | Inflammation research |
| materialart | 1 |
| notes | Abstract The effect of econazole on the release of thromboxanes was investigated. It was found that econazole inhibited concentration-dependently the aggregation of guinea pig platelets stimulated with arachidonic acid. The compound also reduced significantly the LTB4-induced contraction of guinea pig lung parenchyma strips and the contraction of rabbit aorta to the effluent of LTD4-stimulated guinea pig lungs, both effects mediated mostly by thromboxane generation. The concentration of TXB2 in the effluents from LTD4 stimulated lungs, assayed by EIA, was significantly reduced following pretreatment of the lungs with 10−4 M and 10−5 M of econazole, whereas the levels of PGE2 were increased. These results demonstrate that econazole is a selective inhibitor of thromboxane synthesis. |
| package_name | Springer |
| publikationsjahr_anzeige | 1991 |
| publikationsjahr_facette | 1991 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1991 |
| publisher | Springer |
| reference | 34 (1991), S. 387-392 |
| search_space | articles |
| shingle_author_1 | Jancar, S. Teixeira, C. F. P. Tavares de Lima, W. Hoshikawa Fujimura, A. Y. Sirois, P. |
| shingle_author_2 | Jancar, S. Teixeira, C. F. P. Tavares de Lima, W. Hoshikawa Fujimura, A. Y. Sirois, P. |
| shingle_author_3 | Jancar, S. Teixeira, C. F. P. Tavares de Lima, W. Hoshikawa Fujimura, A. Y. Sirois, P. |
| shingle_author_4 | Jancar, S. Teixeira, C. F. P. Tavares de Lima, W. Hoshikawa Fujimura, A. Y. Sirois, P. |
| shingle_catch_all_1 | Jancar, S. Teixeira, C. F. P. Tavares de Lima, W. Hoshikawa Fujimura, A. Y. Sirois, P. Inhibitory effect of econazole on the release of thromboxanes Abstract The effect of econazole on the release of thromboxanes was investigated. It was found that econazole inhibited concentration-dependently the aggregation of guinea pig platelets stimulated with arachidonic acid. The compound also reduced significantly the LTB4-induced contraction of guinea pig lung parenchyma strips and the contraction of rabbit aorta to the effluent of LTD4-stimulated guinea pig lungs, both effects mediated mostly by thromboxane generation. The concentration of TXB2 in the effluents from LTD4 stimulated lungs, assayed by EIA, was significantly reduced following pretreatment of the lungs with 10−4 M and 10−5 M of econazole, whereas the levels of PGE2 were increased. These results demonstrate that econazole is a selective inhibitor of thromboxane synthesis. 1420-908X 1420908X Springer |
| shingle_catch_all_2 | Jancar, S. Teixeira, C. F. P. Tavares de Lima, W. Hoshikawa Fujimura, A. Y. Sirois, P. Inhibitory effect of econazole on the release of thromboxanes Abstract The effect of econazole on the release of thromboxanes was investigated. It was found that econazole inhibited concentration-dependently the aggregation of guinea pig platelets stimulated with arachidonic acid. The compound also reduced significantly the LTB4-induced contraction of guinea pig lung parenchyma strips and the contraction of rabbit aorta to the effluent of LTD4-stimulated guinea pig lungs, both effects mediated mostly by thromboxane generation. The concentration of TXB2 in the effluents from LTD4 stimulated lungs, assayed by EIA, was significantly reduced following pretreatment of the lungs with 10−4 M and 10−5 M of econazole, whereas the levels of PGE2 were increased. These results demonstrate that econazole is a selective inhibitor of thromboxane synthesis. 1420-908X 1420908X Springer |
| shingle_catch_all_3 | Jancar, S. Teixeira, C. F. P. Tavares de Lima, W. Hoshikawa Fujimura, A. Y. Sirois, P. Inhibitory effect of econazole on the release of thromboxanes Abstract The effect of econazole on the release of thromboxanes was investigated. It was found that econazole inhibited concentration-dependently the aggregation of guinea pig platelets stimulated with arachidonic acid. The compound also reduced significantly the LTB4-induced contraction of guinea pig lung parenchyma strips and the contraction of rabbit aorta to the effluent of LTD4-stimulated guinea pig lungs, both effects mediated mostly by thromboxane generation. The concentration of TXB2 in the effluents from LTD4 stimulated lungs, assayed by EIA, was significantly reduced following pretreatment of the lungs with 10−4 M and 10−5 M of econazole, whereas the levels of PGE2 were increased. These results demonstrate that econazole is a selective inhibitor of thromboxane synthesis. 1420-908X 1420908X Springer |
| shingle_catch_all_4 | Jancar, S. Teixeira, C. F. P. Tavares de Lima, W. Hoshikawa Fujimura, A. Y. Sirois, P. Inhibitory effect of econazole on the release of thromboxanes Abstract The effect of econazole on the release of thromboxanes was investigated. It was found that econazole inhibited concentration-dependently the aggregation of guinea pig platelets stimulated with arachidonic acid. The compound also reduced significantly the LTB4-induced contraction of guinea pig lung parenchyma strips and the contraction of rabbit aorta to the effluent of LTD4-stimulated guinea pig lungs, both effects mediated mostly by thromboxane generation. The concentration of TXB2 in the effluents from LTD4 stimulated lungs, assayed by EIA, was significantly reduced following pretreatment of the lungs with 10−4 M and 10−5 M of econazole, whereas the levels of PGE2 were increased. These results demonstrate that econazole is a selective inhibitor of thromboxane synthesis. 1420-908X 1420908X Springer |
| shingle_title_1 | Inhibitory effect of econazole on the release of thromboxanes |
| shingle_title_2 | Inhibitory effect of econazole on the release of thromboxanes |
| shingle_title_3 | Inhibitory effect of econazole on the release of thromboxanes |
| shingle_title_4 | Inhibitory effect of econazole on the release of thromboxanes |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:34:51.346Z |
| titel | Inhibitory effect of econazole on the release of thromboxanes |
| titel_suche | Inhibitory effect of econazole on the release of thromboxanes |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM18911097X |