Inhibitory effect of econazole on the release of thromboxanes
Jancar, S. ; Teixeira, C. F. P. ; Tavares de Lima, W. ; Hoshikawa Fujimura, A. Y. ; Sirois, P.
Springer
Published 1991
Springer
Published 1991
ISSN: |
1420-908X
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Source: |
Springer Online Journal Archives 1860-2000
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Topics: |
Medicine
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Notes: |
Abstract The effect of econazole on the release of thromboxanes was investigated. It was found that econazole inhibited concentration-dependently the aggregation of guinea pig platelets stimulated with arachidonic acid. The compound also reduced significantly the LTB4-induced contraction of guinea pig lung parenchyma strips and the contraction of rabbit aorta to the effluent of LTD4-stimulated guinea pig lungs, both effects mediated mostly by thromboxane generation. The concentration of TXB2 in the effluents from LTD4 stimulated lungs, assayed by EIA, was significantly reduced following pretreatment of the lungs with 10−4 M and 10−5 M of econazole, whereas the levels of PGE2 were increased. These results demonstrate that econazole is a selective inhibitor of thromboxane synthesis.
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Type of Medium: |
Electronic Resource
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URL: |