Dendritic Cells Present an Intracellular Viral Antigen Derived from Apoptotic Cells and Induce a T-Cell Response
VAN ZANTEN, J. ; HOSPERS, G. A. P. ; HARMSEN, M. C. ; THE, T. H. ; MULDER, N. H. ; DE LEIJ, L. F. M. H.
Oxford, UK : Blackwell Science Ltd
Published 2002
Oxford, UK : Blackwell Science Ltd
Published 2002
| ISSN: |
1365-3083
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| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
We investigated if dendritic cells (DCs) were able to present intracellularly located antigens derived from apoptotic cells to T cells, thereby inducing a CD4+ and a CD8+ response. A transfected cell line with the cytomegalovirus-derived protein pp65 was triggered to go into apoptosis by ultraviolet B (UVB) irradiation, and after the uptake of apoptotic cells by DC, the activation and proliferation of T cells were determined. We found that DC efficiently phagocytosed apoptotic cells and induced a CD4+ and a CD8+ T-cell response specific for the viral protein pp65. This mechanism can be useful for vaccination studies to induce an antiviral immune response.
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| Type of Medium: |
Electronic Resource
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| URL: |