Enhanced Activation of CD83-Positive T Cells
Wolenski, M. ; Cramer, S. O. ; Ehrlich, S. ; Steeg, C. ; Fleischer, B. ; Von Bonin, A.
Oxford, UK : Blackwell Science Ltd
Published 2003
Oxford, UK : Blackwell Science Ltd
Published 2003
| ISSN: |
1365-3083
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|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
CD83 is a marker molecule for mature dendritic cells (DCs) but is also substantially expressed on activated T cells in humans and mice. Its function is unknown, but CD83 knockout mice show an impaired thymic maturation of CD4-positive cells and soluble CD83 inhibits partially antigen-specific responses in vitro pointing to a role of CD83 in the immune system. Here we show that CD83-positive T cells produce strongly increased amounts of interferon-γ and interleukin-2. In contrast, constitutive expression of CD83 on DCs alters neither the activation of DCs following addition of lipopolysaccharide nor the ability to present antigenic peptides. Thus, the expression of CD83 on T cells has direct functional consequences for tuning the activation threshold.
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| Type of Medium: |
Electronic Resource
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| URL: |