Regulation of T Helper Cell Differentiation In Vivo by GP43 from Paracoccidioides brasiliensis Provided by Different Antigen-Presenting Cells
| ISSN: |
1365-3083
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|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
Paracoccidioidomycosis, endemic in Latin America, is a progressive systemic mycosis caused by Paracoccidioides brasiliensis. The infection can evolve into different clinical forms that are associated with various degrees of suppressed cell-mediated immunity. Assuming that the effector immune response is a consequence of the preferential activation of either Th1 or Th2 subsets, in the present work we evaluated whether the nature of antigen-presenting cells (APCs) can influence the Th1/Th2 balance in vivo. It was observed that the injection of mature dendritic cells (DCs), macrophages and B cells primed the mice and induced a proliferation of T cells in vitro. It was seen that DCs from resistant mice stimulated predominantly interleukin-2 (IL-2) and interferon-γ (IFN-γ), whereas macrophages activated IL-10, IL-4 and IFN-γ-secreting T cells and B cells IL-4 and IL-10 only. Results presented here clearly demonstrate that DC drives the development of cells secreting Th1-derived cytokines, whereas B cells induce the differentiation of a Th2 phenotype in vivo.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798290232001429505 |
|---|---|
| autor | Ferreira, K. S. Lopes, J. D. Almeida, S. R. |
| book_url | http://dx.doi.org/10.1046/j.1365-3083.2003.01291.x |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLZ243699123 |
| insertion_date | 2012-04-27 |
| issn | 1365-3083 |
| journal_name | Scandinavian journal of immunology |
| materialart | 1 |
| notes | Paracoccidioidomycosis, endemic in Latin America, is a progressive systemic mycosis caused by Paracoccidioides brasiliensis. The infection can evolve into different clinical forms that are associated with various degrees of suppressed cell-mediated immunity. Assuming that the effector immune response is a consequence of the preferential activation of either Th1 or Th2 subsets, in the present work we evaluated whether the nature of antigen-presenting cells (APCs) can influence the Th1/Th2 balance in vivo. It was observed that the injection of mature dendritic cells (DCs), macrophages and B cells primed the mice and induced a proliferation of T cells in vitro. It was seen that DCs from resistant mice stimulated predominantly interleukin-2 (IL-2) and interferon-γ (IFN-γ), whereas macrophages activated IL-10, IL-4 and IFN-γ-secreting T cells and B cells IL-4 and IL-10 only. Results presented here clearly demonstrate that DC drives the development of cells secreting Th1-derived cytokines, whereas B cells induce the differentiation of a Th2 phenotype in vivo. |
| package_name | Blackwell Publishing |
| publikationsjahr_anzeige | 2003 |
| publikationsjahr_facette | 2003 |
| publikationsjahr_intervall | 7999:2000-2004 |
| publikationsjahr_sort | 2003 |
| publikationsort | Oxford, UK |
| publisher | Blackwell Science Ltd |
| reference | 58 (2003), S. 0 |
| search_space | articles |
| shingle_author_1 | Ferreira, K. S. Lopes, J. D. Almeida, S. R. |
| shingle_author_2 | Ferreira, K. S. Lopes, J. D. Almeida, S. R. |
| shingle_author_3 | Ferreira, K. S. Lopes, J. D. Almeida, S. R. |
| shingle_author_4 | Ferreira, K. S. Lopes, J. D. Almeida, S. R. |
| shingle_catch_all_1 | Ferreira, K. S. Lopes, J. D. Almeida, S. R. Regulation of T Helper Cell Differentiation In Vivo by GP43 from Paracoccidioides brasiliensis Provided by Different Antigen-Presenting Cells Blackwell Science Ltd Paracoccidioidomycosis, endemic in Latin America, is a progressive systemic mycosis caused by Paracoccidioides brasiliensis. The infection can evolve into different clinical forms that are associated with various degrees of suppressed cell-mediated immunity. Assuming that the effector immune response is a consequence of the preferential activation of either Th1 or Th2 subsets, in the present work we evaluated whether the nature of antigen-presenting cells (APCs) can influence the Th1/Th2 balance in vivo. It was observed that the injection of mature dendritic cells (DCs), macrophages and B cells primed the mice and induced a proliferation of T cells in vitro. It was seen that DCs from resistant mice stimulated predominantly interleukin-2 (IL-2) and interferon-γ (IFN-γ), whereas macrophages activated IL-10, IL-4 and IFN-γ-secreting T cells and B cells IL-4 and IL-10 only. Results presented here clearly demonstrate that DC drives the development of cells secreting Th1-derived cytokines, whereas B cells induce the differentiation of a Th2 phenotype in vivo. 1365-3083 13653083 |
| shingle_catch_all_2 | Ferreira, K. S. Lopes, J. D. Almeida, S. R. Regulation of T Helper Cell Differentiation In Vivo by GP43 from Paracoccidioides brasiliensis Provided by Different Antigen-Presenting Cells Blackwell Science Ltd Paracoccidioidomycosis, endemic in Latin America, is a progressive systemic mycosis caused by Paracoccidioides brasiliensis. The infection can evolve into different clinical forms that are associated with various degrees of suppressed cell-mediated immunity. Assuming that the effector immune response is a consequence of the preferential activation of either Th1 or Th2 subsets, in the present work we evaluated whether the nature of antigen-presenting cells (APCs) can influence the Th1/Th2 balance in vivo. It was observed that the injection of mature dendritic cells (DCs), macrophages and B cells primed the mice and induced a proliferation of T cells in vitro. It was seen that DCs from resistant mice stimulated predominantly interleukin-2 (IL-2) and interferon-γ (IFN-γ), whereas macrophages activated IL-10, IL-4 and IFN-γ-secreting T cells and B cells IL-4 and IL-10 only. Results presented here clearly demonstrate that DC drives the development of cells secreting Th1-derived cytokines, whereas B cells induce the differentiation of a Th2 phenotype in vivo. 1365-3083 13653083 |
| shingle_catch_all_3 | Ferreira, K. S. Lopes, J. D. Almeida, S. R. Regulation of T Helper Cell Differentiation In Vivo by GP43 from Paracoccidioides brasiliensis Provided by Different Antigen-Presenting Cells Blackwell Science Ltd Paracoccidioidomycosis, endemic in Latin America, is a progressive systemic mycosis caused by Paracoccidioides brasiliensis. The infection can evolve into different clinical forms that are associated with various degrees of suppressed cell-mediated immunity. Assuming that the effector immune response is a consequence of the preferential activation of either Th1 or Th2 subsets, in the present work we evaluated whether the nature of antigen-presenting cells (APCs) can influence the Th1/Th2 balance in vivo. It was observed that the injection of mature dendritic cells (DCs), macrophages and B cells primed the mice and induced a proliferation of T cells in vitro. It was seen that DCs from resistant mice stimulated predominantly interleukin-2 (IL-2) and interferon-γ (IFN-γ), whereas macrophages activated IL-10, IL-4 and IFN-γ-secreting T cells and B cells IL-4 and IL-10 only. Results presented here clearly demonstrate that DC drives the development of cells secreting Th1-derived cytokines, whereas B cells induce the differentiation of a Th2 phenotype in vivo. 1365-3083 13653083 |
| shingle_catch_all_4 | Ferreira, K. S. Lopes, J. D. Almeida, S. R. Regulation of T Helper Cell Differentiation In Vivo by GP43 from Paracoccidioides brasiliensis Provided by Different Antigen-Presenting Cells Blackwell Science Ltd Paracoccidioidomycosis, endemic in Latin America, is a progressive systemic mycosis caused by Paracoccidioides brasiliensis. The infection can evolve into different clinical forms that are associated with various degrees of suppressed cell-mediated immunity. Assuming that the effector immune response is a consequence of the preferential activation of either Th1 or Th2 subsets, in the present work we evaluated whether the nature of antigen-presenting cells (APCs) can influence the Th1/Th2 balance in vivo. It was observed that the injection of mature dendritic cells (DCs), macrophages and B cells primed the mice and induced a proliferation of T cells in vitro. It was seen that DCs from resistant mice stimulated predominantly interleukin-2 (IL-2) and interferon-γ (IFN-γ), whereas macrophages activated IL-10, IL-4 and IFN-γ-secreting T cells and B cells IL-4 and IL-10 only. Results presented here clearly demonstrate that DC drives the development of cells secreting Th1-derived cytokines, whereas B cells induce the differentiation of a Th2 phenotype in vivo. 1365-3083 13653083 |
| shingle_title_1 | Regulation of T Helper Cell Differentiation In Vivo by GP43 from Paracoccidioides brasiliensis Provided by Different Antigen-Presenting Cells |
| shingle_title_2 | Regulation of T Helper Cell Differentiation In Vivo by GP43 from Paracoccidioides brasiliensis Provided by Different Antigen-Presenting Cells |
| shingle_title_3 | Regulation of T Helper Cell Differentiation In Vivo by GP43 from Paracoccidioides brasiliensis Provided by Different Antigen-Presenting Cells |
| shingle_title_4 | Regulation of T Helper Cell Differentiation In Vivo by GP43 from Paracoccidioides brasiliensis Provided by Different Antigen-Presenting Cells |
| sigel_instance_filter | dkfz geomar wilbert ipn albert |
| source_archive | Blackwell Publishing Journal Backfiles 1879-2005 |
| timestamp | 2024-05-06T08:13:27.252Z |
| titel | Regulation of T Helper Cell Differentiation In Vivo by GP43 from Paracoccidioides brasiliensis Provided by Different Antigen-Presenting Cells |
| titel_suche | Regulation of T Helper Cell Differentiation In Vivo by GP43 from Paracoccidioides brasiliensis Provided by Different Antigen-Presenting Cells |
| topic | WW-YZ |
| uid | nat_lic_papers_NLZ243699123 |