Short term follow up of childhood focal segmental glomerulosclerosis in India

GULATI, S ; KHER, V ; JAIN, M ; MITTAL, S ; ARORA, P ; GUPTA, A ; GUPTA, RK

Oxford, UK : Blackwell Publishing Ltd
Published 1997
ISSN:
1440-1797
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Summary: A retrospective analysis of 67 biopsy proven cases of focal segmental glomerulosclerosis (FSGS) in children was performed. After a mean duration of disease of 48.5 ± 44 months, 20 patients (30%) achieved sustained remission (SR), 23 (34%) had frequent relapses (FR) and 24 (36%) were steroid non-responders (NR). the NR group had a significantly higher mean age of onset 9.1 ± 1.01 years (P= 0.003) and had higher number of females (P= 0.0009). They also had a significantly higher prevalence of microhaematuria as compared to FR and SR groups (P= 0.002). the initial steroid response category (P〈0.00001) and the percentage of glomeruli with segmental sclerosis on histopathology (P= 0.001) correlated with the subsequent outcome. During this period six children developed progressive renal failure and all of them belonged to NR group (25%). There were four deaths and all of them were non-responders (16.6%). Features predictive of a poor therapeutic outcome in childhood FSGS are age of onset more than 9 years, female sex, microhaematuria, renal dysfunction at onset, initial non-response to steroids and percentage of glomeruli with segmental sclerosis on histopathology.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1440-1797.1997.tb00263.x
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autor GULATI, S
KHER, V
JAIN, M
MITTAL, S
ARORA, P
GUPTA, A
GUPTA, RK
autorsonst MITTAL, S
ARORA, P
GUPTA, A
GUPTA, RK
book_url http://dx.doi.org/10.1111/j.1440-1797.1997.tb00263.x
datenlieferant nat_lic_papers
hauptsatz hsatz_simple
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insertion_date 2012-04-27
issn 1440-1797
journal_name Nephrology
materialart 1
notes Summary: A retrospective analysis of 67 biopsy proven cases of focal segmental glomerulosclerosis (FSGS) in children was performed. After a mean duration of disease of 48.5 ± 44 months, 20 patients (30%) achieved sustained remission (SR), 23 (34%) had frequent relapses (FR) and 24 (36%) were steroid non-responders (NR). the NR group had a significantly higher mean age of onset 9.1 ± 1.01 years (P= 0.003) and had higher number of females (P= 0.0009). They also had a significantly higher prevalence of microhaematuria as compared to FR and SR groups (P= 0.002). the initial steroid response category (P〈0.00001) and the percentage of glomeruli with segmental sclerosis on histopathology (P= 0.001) correlated with the subsequent outcome. During this period six children developed progressive renal failure and all of them belonged to NR group (25%). There were four deaths and all of them were non-responders (16.6%). Features predictive of a poor therapeutic outcome in childhood FSGS are age of onset more than 9 years, female sex, microhaematuria, renal dysfunction at onset, initial non-response to steroids and percentage of glomeruli with segmental sclerosis on histopathology.
package_name Blackwell Publishing
publikationsjahr_anzeige 1997
publikationsjahr_facette 1997
publikationsjahr_intervall 8004:1995-1999
publikationsjahr_sort 1997
publikationsort Oxford, UK
publisher Blackwell Publishing Ltd
reference 3 (1997), S. 0
search_space articles
shingle_author_1 GULATI, S
KHER, V
JAIN, M
MITTAL, S
ARORA, P
GUPTA, A
GUPTA, RK
shingle_author_2 GULATI, S
KHER, V
JAIN, M
MITTAL, S
ARORA, P
GUPTA, A
GUPTA, RK
shingle_author_3 GULATI, S
KHER, V
JAIN, M
MITTAL, S
ARORA, P
GUPTA, A
GUPTA, RK
shingle_author_4 GULATI, S
KHER, V
JAIN, M
MITTAL, S
ARORA, P
GUPTA, A
GUPTA, RK
shingle_catch_all_1 GULATI, S
KHER, V
JAIN, M
MITTAL, S
ARORA, P
GUPTA, A
GUPTA, RK
Short term follow up of childhood focal segmental glomerulosclerosis in India
Blackwell Publishing Ltd
Summary: A retrospective analysis of 67 biopsy proven cases of focal segmental glomerulosclerosis (FSGS) in children was performed. After a mean duration of disease of 48.5 ± 44 months, 20 patients (30%) achieved sustained remission (SR), 23 (34%) had frequent relapses (FR) and 24 (36%) were steroid non-responders (NR). the NR group had a significantly higher mean age of onset 9.1 ± 1.01 years (P= 0.003) and had higher number of females (P= 0.0009). They also had a significantly higher prevalence of microhaematuria as compared to FR and SR groups (P= 0.002). the initial steroid response category (P〈0.00001) and the percentage of glomeruli with segmental sclerosis on histopathology (P= 0.001) correlated with the subsequent outcome. During this period six children developed progressive renal failure and all of them belonged to NR group (25%). There were four deaths and all of them were non-responders (16.6%). Features predictive of a poor therapeutic outcome in childhood FSGS are age of onset more than 9 years, female sex, microhaematuria, renal dysfunction at onset, initial non-response to steroids and percentage of glomeruli with segmental sclerosis on histopathology.
1440-1797
14401797
shingle_catch_all_2 GULATI, S
KHER, V
JAIN, M
MITTAL, S
ARORA, P
GUPTA, A
GUPTA, RK
Short term follow up of childhood focal segmental glomerulosclerosis in India
Blackwell Publishing Ltd
Summary: A retrospective analysis of 67 biopsy proven cases of focal segmental glomerulosclerosis (FSGS) in children was performed. After a mean duration of disease of 48.5 ± 44 months, 20 patients (30%) achieved sustained remission (SR), 23 (34%) had frequent relapses (FR) and 24 (36%) were steroid non-responders (NR). the NR group had a significantly higher mean age of onset 9.1 ± 1.01 years (P= 0.003) and had higher number of females (P= 0.0009). They also had a significantly higher prevalence of microhaematuria as compared to FR and SR groups (P= 0.002). the initial steroid response category (P〈0.00001) and the percentage of glomeruli with segmental sclerosis on histopathology (P= 0.001) correlated with the subsequent outcome. During this period six children developed progressive renal failure and all of them belonged to NR group (25%). There were four deaths and all of them were non-responders (16.6%). Features predictive of a poor therapeutic outcome in childhood FSGS are age of onset more than 9 years, female sex, microhaematuria, renal dysfunction at onset, initial non-response to steroids and percentage of glomeruli with segmental sclerosis on histopathology.
1440-1797
14401797
shingle_catch_all_3 GULATI, S
KHER, V
JAIN, M
MITTAL, S
ARORA, P
GUPTA, A
GUPTA, RK
Short term follow up of childhood focal segmental glomerulosclerosis in India
Blackwell Publishing Ltd
Summary: A retrospective analysis of 67 biopsy proven cases of focal segmental glomerulosclerosis (FSGS) in children was performed. After a mean duration of disease of 48.5 ± 44 months, 20 patients (30%) achieved sustained remission (SR), 23 (34%) had frequent relapses (FR) and 24 (36%) were steroid non-responders (NR). the NR group had a significantly higher mean age of onset 9.1 ± 1.01 years (P= 0.003) and had higher number of females (P= 0.0009). They also had a significantly higher prevalence of microhaematuria as compared to FR and SR groups (P= 0.002). the initial steroid response category (P〈0.00001) and the percentage of glomeruli with segmental sclerosis on histopathology (P= 0.001) correlated with the subsequent outcome. During this period six children developed progressive renal failure and all of them belonged to NR group (25%). There were four deaths and all of them were non-responders (16.6%). Features predictive of a poor therapeutic outcome in childhood FSGS are age of onset more than 9 years, female sex, microhaematuria, renal dysfunction at onset, initial non-response to steroids and percentage of glomeruli with segmental sclerosis on histopathology.
1440-1797
14401797
shingle_catch_all_4 GULATI, S
KHER, V
JAIN, M
MITTAL, S
ARORA, P
GUPTA, A
GUPTA, RK
Short term follow up of childhood focal segmental glomerulosclerosis in India
Blackwell Publishing Ltd
Summary: A retrospective analysis of 67 biopsy proven cases of focal segmental glomerulosclerosis (FSGS) in children was performed. After a mean duration of disease of 48.5 ± 44 months, 20 patients (30%) achieved sustained remission (SR), 23 (34%) had frequent relapses (FR) and 24 (36%) were steroid non-responders (NR). the NR group had a significantly higher mean age of onset 9.1 ± 1.01 years (P= 0.003) and had higher number of females (P= 0.0009). They also had a significantly higher prevalence of microhaematuria as compared to FR and SR groups (P= 0.002). the initial steroid response category (P〈0.00001) and the percentage of glomeruli with segmental sclerosis on histopathology (P= 0.001) correlated with the subsequent outcome. During this period six children developed progressive renal failure and all of them belonged to NR group (25%). There were four deaths and all of them were non-responders (16.6%). Features predictive of a poor therapeutic outcome in childhood FSGS are age of onset more than 9 years, female sex, microhaematuria, renal dysfunction at onset, initial non-response to steroids and percentage of glomeruli with segmental sclerosis on histopathology.
1440-1797
14401797
shingle_title_1 Short term follow up of childhood focal segmental glomerulosclerosis in India
shingle_title_2 Short term follow up of childhood focal segmental glomerulosclerosis in India
shingle_title_3 Short term follow up of childhood focal segmental glomerulosclerosis in India
shingle_title_4 Short term follow up of childhood focal segmental glomerulosclerosis in India
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titel Short term follow up of childhood focal segmental glomerulosclerosis in India
titel_suche Short term follow up of childhood focal segmental glomerulosclerosis in India
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