Short term follow up of childhood focal segmental glomerulosclerosis in India
GULATI, S ; KHER, V ; JAIN, M ; MITTAL, S ; ARORA, P ; GUPTA, A ; GUPTA, RK
Oxford, UK : Blackwell Publishing Ltd
Published 1997
Oxford, UK : Blackwell Publishing Ltd
Published 1997
ISSN: |
1440-1797
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Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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Topics: |
Medicine
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Notes: |
Summary: A retrospective analysis of 67 biopsy proven cases of focal segmental glomerulosclerosis (FSGS) in children was performed. After a mean duration of disease of 48.5 ± 44 months, 20 patients (30%) achieved sustained remission (SR), 23 (34%) had frequent relapses (FR) and 24 (36%) were steroid non-responders (NR). the NR group had a significantly higher mean age of onset 9.1 ± 1.01 years (P= 0.003) and had higher number of females (P= 0.0009). They also had a significantly higher prevalence of microhaematuria as compared to FR and SR groups (P= 0.002). the initial steroid response category (P〈0.00001) and the percentage of glomeruli with segmental sclerosis on histopathology (P= 0.001) correlated with the subsequent outcome. During this period six children developed progressive renal failure and all of them belonged to NR group (25%). There were four deaths and all of them were non-responders (16.6%). Features predictive of a poor therapeutic outcome in childhood FSGS are age of onset more than 9 years, female sex, microhaematuria, renal dysfunction at onset, initial non-response to steroids and percentage of glomeruli with segmental sclerosis on histopathology.
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Type of Medium: |
Electronic Resource
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URL: |
_version_ | 1798290150034243584 |
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autor | GULATI, S KHER, V JAIN, M MITTAL, S ARORA, P GUPTA, A GUPTA, RK |
autorsonst | MITTAL, S ARORA, P GUPTA, A GUPTA, RK |
book_url | http://dx.doi.org/10.1111/j.1440-1797.1997.tb00263.x |
datenlieferant | nat_lic_papers |
hauptsatz | hsatz_simple |
identnr | NLZ24351834X |
insertion_date | 2012-04-27 |
issn | 1440-1797 |
journal_name | Nephrology |
materialart | 1 |
notes | Summary: A retrospective analysis of 67 biopsy proven cases of focal segmental glomerulosclerosis (FSGS) in children was performed. After a mean duration of disease of 48.5 ± 44 months, 20 patients (30%) achieved sustained remission (SR), 23 (34%) had frequent relapses (FR) and 24 (36%) were steroid non-responders (NR). the NR group had a significantly higher mean age of onset 9.1 ± 1.01 years (P= 0.003) and had higher number of females (P= 0.0009). They also had a significantly higher prevalence of microhaematuria as compared to FR and SR groups (P= 0.002). the initial steroid response category (P〈0.00001) and the percentage of glomeruli with segmental sclerosis on histopathology (P= 0.001) correlated with the subsequent outcome. During this period six children developed progressive renal failure and all of them belonged to NR group (25%). There were four deaths and all of them were non-responders (16.6%). Features predictive of a poor therapeutic outcome in childhood FSGS are age of onset more than 9 years, female sex, microhaematuria, renal dysfunction at onset, initial non-response to steroids and percentage of glomeruli with segmental sclerosis on histopathology. |
package_name | Blackwell Publishing |
publikationsjahr_anzeige | 1997 |
publikationsjahr_facette | 1997 |
publikationsjahr_intervall | 8004:1995-1999 |
publikationsjahr_sort | 1997 |
publikationsort | Oxford, UK |
publisher | Blackwell Publishing Ltd |
reference | 3 (1997), S. 0 |
search_space | articles |
shingle_author_1 | GULATI, S KHER, V JAIN, M MITTAL, S ARORA, P GUPTA, A GUPTA, RK |
shingle_author_2 | GULATI, S KHER, V JAIN, M MITTAL, S ARORA, P GUPTA, A GUPTA, RK |
shingle_author_3 | GULATI, S KHER, V JAIN, M MITTAL, S ARORA, P GUPTA, A GUPTA, RK |
shingle_author_4 | GULATI, S KHER, V JAIN, M MITTAL, S ARORA, P GUPTA, A GUPTA, RK |
shingle_catch_all_1 | GULATI, S KHER, V JAIN, M MITTAL, S ARORA, P GUPTA, A GUPTA, RK Short term follow up of childhood focal segmental glomerulosclerosis in India Blackwell Publishing Ltd Summary: A retrospective analysis of 67 biopsy proven cases of focal segmental glomerulosclerosis (FSGS) in children was performed. After a mean duration of disease of 48.5 ± 44 months, 20 patients (30%) achieved sustained remission (SR), 23 (34%) had frequent relapses (FR) and 24 (36%) were steroid non-responders (NR). the NR group had a significantly higher mean age of onset 9.1 ± 1.01 years (P= 0.003) and had higher number of females (P= 0.0009). They also had a significantly higher prevalence of microhaematuria as compared to FR and SR groups (P= 0.002). the initial steroid response category (P〈0.00001) and the percentage of glomeruli with segmental sclerosis on histopathology (P= 0.001) correlated with the subsequent outcome. During this period six children developed progressive renal failure and all of them belonged to NR group (25%). There were four deaths and all of them were non-responders (16.6%). Features predictive of a poor therapeutic outcome in childhood FSGS are age of onset more than 9 years, female sex, microhaematuria, renal dysfunction at onset, initial non-response to steroids and percentage of glomeruli with segmental sclerosis on histopathology. 1440-1797 14401797 |
shingle_catch_all_2 | GULATI, S KHER, V JAIN, M MITTAL, S ARORA, P GUPTA, A GUPTA, RK Short term follow up of childhood focal segmental glomerulosclerosis in India Blackwell Publishing Ltd Summary: A retrospective analysis of 67 biopsy proven cases of focal segmental glomerulosclerosis (FSGS) in children was performed. After a mean duration of disease of 48.5 ± 44 months, 20 patients (30%) achieved sustained remission (SR), 23 (34%) had frequent relapses (FR) and 24 (36%) were steroid non-responders (NR). the NR group had a significantly higher mean age of onset 9.1 ± 1.01 years (P= 0.003) and had higher number of females (P= 0.0009). They also had a significantly higher prevalence of microhaematuria as compared to FR and SR groups (P= 0.002). the initial steroid response category (P〈0.00001) and the percentage of glomeruli with segmental sclerosis on histopathology (P= 0.001) correlated with the subsequent outcome. During this period six children developed progressive renal failure and all of them belonged to NR group (25%). There were four deaths and all of them were non-responders (16.6%). Features predictive of a poor therapeutic outcome in childhood FSGS are age of onset more than 9 years, female sex, microhaematuria, renal dysfunction at onset, initial non-response to steroids and percentage of glomeruli with segmental sclerosis on histopathology. 1440-1797 14401797 |
shingle_catch_all_3 | GULATI, S KHER, V JAIN, M MITTAL, S ARORA, P GUPTA, A GUPTA, RK Short term follow up of childhood focal segmental glomerulosclerosis in India Blackwell Publishing Ltd Summary: A retrospective analysis of 67 biopsy proven cases of focal segmental glomerulosclerosis (FSGS) in children was performed. After a mean duration of disease of 48.5 ± 44 months, 20 patients (30%) achieved sustained remission (SR), 23 (34%) had frequent relapses (FR) and 24 (36%) were steroid non-responders (NR). the NR group had a significantly higher mean age of onset 9.1 ± 1.01 years (P= 0.003) and had higher number of females (P= 0.0009). They also had a significantly higher prevalence of microhaematuria as compared to FR and SR groups (P= 0.002). the initial steroid response category (P〈0.00001) and the percentage of glomeruli with segmental sclerosis on histopathology (P= 0.001) correlated with the subsequent outcome. During this period six children developed progressive renal failure and all of them belonged to NR group (25%). There were four deaths and all of them were non-responders (16.6%). Features predictive of a poor therapeutic outcome in childhood FSGS are age of onset more than 9 years, female sex, microhaematuria, renal dysfunction at onset, initial non-response to steroids and percentage of glomeruli with segmental sclerosis on histopathology. 1440-1797 14401797 |
shingle_catch_all_4 | GULATI, S KHER, V JAIN, M MITTAL, S ARORA, P GUPTA, A GUPTA, RK Short term follow up of childhood focal segmental glomerulosclerosis in India Blackwell Publishing Ltd Summary: A retrospective analysis of 67 biopsy proven cases of focal segmental glomerulosclerosis (FSGS) in children was performed. After a mean duration of disease of 48.5 ± 44 months, 20 patients (30%) achieved sustained remission (SR), 23 (34%) had frequent relapses (FR) and 24 (36%) were steroid non-responders (NR). the NR group had a significantly higher mean age of onset 9.1 ± 1.01 years (P= 0.003) and had higher number of females (P= 0.0009). They also had a significantly higher prevalence of microhaematuria as compared to FR and SR groups (P= 0.002). the initial steroid response category (P〈0.00001) and the percentage of glomeruli with segmental sclerosis on histopathology (P= 0.001) correlated with the subsequent outcome. During this period six children developed progressive renal failure and all of them belonged to NR group (25%). There were four deaths and all of them were non-responders (16.6%). Features predictive of a poor therapeutic outcome in childhood FSGS are age of onset more than 9 years, female sex, microhaematuria, renal dysfunction at onset, initial non-response to steroids and percentage of glomeruli with segmental sclerosis on histopathology. 1440-1797 14401797 |
shingle_title_1 | Short term follow up of childhood focal segmental glomerulosclerosis in India |
shingle_title_2 | Short term follow up of childhood focal segmental glomerulosclerosis in India |
shingle_title_3 | Short term follow up of childhood focal segmental glomerulosclerosis in India |
shingle_title_4 | Short term follow up of childhood focal segmental glomerulosclerosis in India |
sigel_instance_filter | dkfz geomar wilbert ipn albert |
source_archive | Blackwell Publishing Journal Backfiles 1879-2005 |
timestamp | 2024-05-06T08:12:09.238Z |
titel | Short term follow up of childhood focal segmental glomerulosclerosis in India |
titel_suche | Short term follow up of childhood focal segmental glomerulosclerosis in India |
topic | WW-YZ |
uid | nat_lic_papers_NLZ24351834X |