Gonadotrophin Inhibitory Hormone Depresses Gonadotrophin α and Follicle-Stimulating Hormone β Subunit Expression in the Pituitary of the Domestic Chicken
Ciccone, N. A. ; Dunn, I. C. ; Boswell, T. ; Tsutsui, K. ; Ubuka, T. ; Ukena, K. ; Sharp, P. J.
Oxford, UK : Blackwell Science Ltd
Published 2004
Oxford, UK : Blackwell Science Ltd
Published 2004
| ISSN: |
1365-2826
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| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
Studies performed in vitro suggest that a novel 12 amino acid RF amide peptide, isolated from the quail hypothalamus, is a gonadotrophin inhibitory hormone (GnIH). The aim of the present study was to investigate this hypothesis in the domestic chicken. Injections of GnIH into nest-deprived incubating hens failed to depress the concentration of plasma luteinizing hormone (LH). Addition of GnIH to short-term (120 min) cultures of diced pituitary glands from adult cockerels depressed follicle-stimulating hormone (FSH) and LH release and depressed common α and FSHβ gonadotrophin subunit mRNAs, with no effect on LHβ subunit mRNA. Hypothalamic GnIH mRNA was higher in incubating (out-of-lay) than in laying hens, but there was no significant difference in the amount of hypothalamic GnIH mRNA in out-of-lay and laying broiler breeder hens at the end of a laying year. It is concluded that avian GnIH may play a role in controlling gonadotrophin synthesis and associated constitutive release in the domestic chicken.
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| Type of Medium: |
Electronic Resource
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| URL: |