Studies on cytotoxicity of nickel ions using C3H10T1/2 fibroblast cells
Taira, M. ; Toguchi, M. S. ; Hamada, Y. ; Okazaki, M. ; Takahashi, J. ; Ito, R. ; Toyosawa, S. ; Ijyuin, N.
Oxford, UK : Blackwell Science Ltd
Published 2000
Oxford, UK : Blackwell Science Ltd
Published 2000
| ISSN: |
1365-2842
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| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
Cytotoxicity of Ni ions were examined using C3H mouse derived 10T1/2 fibroblast cells. It became evident that Ni ions had dose-dependent cytotoxicity. The cell number incubated in DME medium containing 0·04 mm/L Ni ion for 6 days was reduced to half that in control DME medium without Ni. The cell totally disappeared in DME medium containing 2 mm/L Ni ion. The dissolution of Ni ions from Ni-containing metallic restorations must be lower than these concentration levels so that oral tissues might not be damaged. No neoplastic transformation was found on all cells examined.
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| Type of Medium: |
Electronic Resource
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| URL: |