Successful liver transplantation in a patient with severe haemophilia A and a high-titre factor VIII inhibitor
Ashrani, A. A. ; Reding, M. T. ; Shet, A. ; Osip, J. ; Humar, A. ; Lake, J. R. ; Key, N. S.
Oxford, UK : Blackwell Science Ltd
Published 2004
Oxford, UK : Blackwell Science Ltd
Published 2004
| ISSN: |
1365-2516
|
|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
|
| Topics: |
Medicine
|
| Notes: |
Summary. We present the case of a 61-year-old man with severe haemophilia A and a high-titre factor VIII inhibitor who underwent successful orthotopic liver transplantation (OLT) for hepatocellular carcinoma. Postoperatively, a modest early anamnestic response to FVIII was followed by immunological tolerance to FVIII. This case illustrates the technical feasibility of OLT in some patients with high-titre inhibitors to FVIII, and suggests that immune tolerance may be induced by endogenously produced FVIII from the transplanted organ.
|
| Type of Medium: |
Electronic Resource
|
| URL: |