Overexpression of anti-apoptotic Mcl-1 in testicular germ cell tumours
Sano, M ; Nakanishi, Y ; Yagasaki, H ; Honma, T ; Oinuma, T ; Obana, Y ; Suzuki, A ; Nemoto, N
Oxford, UK : Blackwell Science Ltd
Published 2005
Oxford, UK : Blackwell Science Ltd
Published 2005
| ISSN: |
1365-2559
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|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
Aims: To determine the expression of Mcl-1 in testicular germ cell tumours in order to clarify the role of this anti-apoptotic factor in these tumours. Various members of the Bcl-2 family have been implicated in the apoptotic mechanisms regulating germ cell apoptosis. Mcl-1 is an anti-apoptotic Bcl-2 family member and has recently been reported to be related to the progression of malignancy; however, the involvement of Mcl-1 in the development of germ cell tumours is still unknown.Methods and results: Mcl-1 expression in testicular germ cell tumours was investigated by immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR). By immunohistochemistry, overexpression of Mcl-1 was present in all germ cell tumours that were studied, including embryonal carcinoma and yolk sac tumour, as well as choriocarcinoma and teratoma. In teratomas, Mcl-1 was widely distributed in the epithelial, myogenic, neural and mesenchymal components. RT-PCR analysis after microdissection revealed high levels of Mcl-1 mRNA in all tumour variants compared with non-neoplastic germ cells.Conclusion: Overexpression of anti-apoptotic Mcl-1 may function to enhance the viability of testicular germ cells, thereby leading to tumorigenesis.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798290213885181956 |
|---|---|
| autor | Sano, M Nakanishi, Y Yagasaki, H Honma, T Oinuma, T Obana, Y Suzuki, A Nemoto, N |
| autorsonst | Honma, T Oinuma, T Obana, Y Suzuki, A Nemoto, N |
| book_url | http://dx.doi.org/10.1111/j.1365-2559.2005.02118.x |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLZ242757588 |
| insertion_date | 2012-04-27 |
| issn | 1365-2559 |
| journal_name | Histopathology |
| materialart | 1 |
| notes | Aims: To determine the expression of Mcl-1 in testicular germ cell tumours in order to clarify the role of this anti-apoptotic factor in these tumours. Various members of the Bcl-2 family have been implicated in the apoptotic mechanisms regulating germ cell apoptosis. Mcl-1 is an anti-apoptotic Bcl-2 family member and has recently been reported to be related to the progression of malignancy; however, the involvement of Mcl-1 in the development of germ cell tumours is still unknown.Methods and results: Mcl-1 expression in testicular germ cell tumours was investigated by immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR). By immunohistochemistry, overexpression of Mcl-1 was present in all germ cell tumours that were studied, including embryonal carcinoma and yolk sac tumour, as well as choriocarcinoma and teratoma. In teratomas, Mcl-1 was widely distributed in the epithelial, myogenic, neural and mesenchymal components. RT-PCR analysis after microdissection revealed high levels of Mcl-1 mRNA in all tumour variants compared with non-neoplastic germ cells.Conclusion: Overexpression of anti-apoptotic Mcl-1 may function to enhance the viability of testicular germ cells, thereby leading to tumorigenesis. |
| package_name | Blackwell Publishing |
| publikationsjahr_anzeige | 2005 |
| publikationsjahr_facette | 2005 |
| publikationsjahr_intervall | 7994:2005-2009 |
| publikationsjahr_sort | 2005 |
| publikationsort | Oxford, UK |
| publisher | Blackwell Science Ltd |
| reference | 46 (2005), S. 0 |
| search_space | articles |
| shingle_author_1 | Sano, M Nakanishi, Y Yagasaki, H Honma, T Oinuma, T Obana, Y Suzuki, A Nemoto, N |
| shingle_author_2 | Sano, M Nakanishi, Y Yagasaki, H Honma, T Oinuma, T Obana, Y Suzuki, A Nemoto, N |
| shingle_author_3 | Sano, M Nakanishi, Y Yagasaki, H Honma, T Oinuma, T Obana, Y Suzuki, A Nemoto, N |
| shingle_author_4 | Sano, M Nakanishi, Y Yagasaki, H Honma, T Oinuma, T Obana, Y Suzuki, A Nemoto, N |
| shingle_catch_all_1 | Sano, M Nakanishi, Y Yagasaki, H Honma, T Oinuma, T Obana, Y Suzuki, A Nemoto, N Overexpression of anti-apoptotic Mcl-1 in testicular germ cell tumours Blackwell Science Ltd Aims: To determine the expression of Mcl-1 in testicular germ cell tumours in order to clarify the role of this anti-apoptotic factor in these tumours. Various members of the Bcl-2 family have been implicated in the apoptotic mechanisms regulating germ cell apoptosis. Mcl-1 is an anti-apoptotic Bcl-2 family member and has recently been reported to be related to the progression of malignancy; however, the involvement of Mcl-1 in the development of germ cell tumours is still unknown.Methods and results: Mcl-1 expression in testicular germ cell tumours was investigated by immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR). By immunohistochemistry, overexpression of Mcl-1 was present in all germ cell tumours that were studied, including embryonal carcinoma and yolk sac tumour, as well as choriocarcinoma and teratoma. In teratomas, Mcl-1 was widely distributed in the epithelial, myogenic, neural and mesenchymal components. RT-PCR analysis after microdissection revealed high levels of Mcl-1 mRNA in all tumour variants compared with non-neoplastic germ cells.Conclusion: Overexpression of anti-apoptotic Mcl-1 may function to enhance the viability of testicular germ cells, thereby leading to tumorigenesis. 1365-2559 13652559 |
| shingle_catch_all_2 | Sano, M Nakanishi, Y Yagasaki, H Honma, T Oinuma, T Obana, Y Suzuki, A Nemoto, N Overexpression of anti-apoptotic Mcl-1 in testicular germ cell tumours Blackwell Science Ltd Aims: To determine the expression of Mcl-1 in testicular germ cell tumours in order to clarify the role of this anti-apoptotic factor in these tumours. Various members of the Bcl-2 family have been implicated in the apoptotic mechanisms regulating germ cell apoptosis. Mcl-1 is an anti-apoptotic Bcl-2 family member and has recently been reported to be related to the progression of malignancy; however, the involvement of Mcl-1 in the development of germ cell tumours is still unknown.Methods and results: Mcl-1 expression in testicular germ cell tumours was investigated by immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR). By immunohistochemistry, overexpression of Mcl-1 was present in all germ cell tumours that were studied, including embryonal carcinoma and yolk sac tumour, as well as choriocarcinoma and teratoma. In teratomas, Mcl-1 was widely distributed in the epithelial, myogenic, neural and mesenchymal components. RT-PCR analysis after microdissection revealed high levels of Mcl-1 mRNA in all tumour variants compared with non-neoplastic germ cells.Conclusion: Overexpression of anti-apoptotic Mcl-1 may function to enhance the viability of testicular germ cells, thereby leading to tumorigenesis. 1365-2559 13652559 |
| shingle_catch_all_3 | Sano, M Nakanishi, Y Yagasaki, H Honma, T Oinuma, T Obana, Y Suzuki, A Nemoto, N Overexpression of anti-apoptotic Mcl-1 in testicular germ cell tumours Blackwell Science Ltd Aims: To determine the expression of Mcl-1 in testicular germ cell tumours in order to clarify the role of this anti-apoptotic factor in these tumours. Various members of the Bcl-2 family have been implicated in the apoptotic mechanisms regulating germ cell apoptosis. Mcl-1 is an anti-apoptotic Bcl-2 family member and has recently been reported to be related to the progression of malignancy; however, the involvement of Mcl-1 in the development of germ cell tumours is still unknown.Methods and results: Mcl-1 expression in testicular germ cell tumours was investigated by immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR). By immunohistochemistry, overexpression of Mcl-1 was present in all germ cell tumours that were studied, including embryonal carcinoma and yolk sac tumour, as well as choriocarcinoma and teratoma. In teratomas, Mcl-1 was widely distributed in the epithelial, myogenic, neural and mesenchymal components. RT-PCR analysis after microdissection revealed high levels of Mcl-1 mRNA in all tumour variants compared with non-neoplastic germ cells.Conclusion: Overexpression of anti-apoptotic Mcl-1 may function to enhance the viability of testicular germ cells, thereby leading to tumorigenesis. 1365-2559 13652559 |
| shingle_catch_all_4 | Sano, M Nakanishi, Y Yagasaki, H Honma, T Oinuma, T Obana, Y Suzuki, A Nemoto, N Overexpression of anti-apoptotic Mcl-1 in testicular germ cell tumours Blackwell Science Ltd Aims: To determine the expression of Mcl-1 in testicular germ cell tumours in order to clarify the role of this anti-apoptotic factor in these tumours. Various members of the Bcl-2 family have been implicated in the apoptotic mechanisms regulating germ cell apoptosis. Mcl-1 is an anti-apoptotic Bcl-2 family member and has recently been reported to be related to the progression of malignancy; however, the involvement of Mcl-1 in the development of germ cell tumours is still unknown.Methods and results: Mcl-1 expression in testicular germ cell tumours was investigated by immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR). By immunohistochemistry, overexpression of Mcl-1 was present in all germ cell tumours that were studied, including embryonal carcinoma and yolk sac tumour, as well as choriocarcinoma and teratoma. In teratomas, Mcl-1 was widely distributed in the epithelial, myogenic, neural and mesenchymal components. RT-PCR analysis after microdissection revealed high levels of Mcl-1 mRNA in all tumour variants compared with non-neoplastic germ cells.Conclusion: Overexpression of anti-apoptotic Mcl-1 may function to enhance the viability of testicular germ cells, thereby leading to tumorigenesis. 1365-2559 13652559 |
| shingle_title_1 | Overexpression of anti-apoptotic Mcl-1 in testicular germ cell tumours |
| shingle_title_2 | Overexpression of anti-apoptotic Mcl-1 in testicular germ cell tumours |
| shingle_title_3 | Overexpression of anti-apoptotic Mcl-1 in testicular germ cell tumours |
| shingle_title_4 | Overexpression of anti-apoptotic Mcl-1 in testicular germ cell tumours |
| sigel_instance_filter | dkfz geomar wilbert ipn albert |
| source_archive | Blackwell Publishing Journal Backfiles 1879-2005 |
| timestamp | 2024-05-06T08:13:09.922Z |
| titel | Overexpression of anti-apoptotic Mcl-1 in testicular germ cell tumours |
| titel_suche | Overexpression of anti-apoptotic Mcl-1 in testicular germ cell tumours |
| topic | WW-YZ |
| uid | nat_lic_papers_NLZ242757588 |