Heme oxygenase1 (HSP-32) is induced in myelin-phagocytosing Schwann cells of injured sciatic nerves in the rat
Hirata, Kazuho ; He, Jian-wen ; Kuraoka, Akio ; Omata, Yoshiaki ; Hirata, Mizuki ; Islam, A. T. M. Shariful ; Noguchi, Masato ; Kawabuchi, Masaru
Oxford, UK : Blackwell Science Ltd
Published 2000
Oxford, UK : Blackwell Science Ltd
Published 2000
| ISSN: |
1460-9568
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| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
Schwann cells participate in myelin phagocytosis in the early stage of Wallerian degeneration, prior to the recruitment of macrophages. This is the first report that Schwann cells induce heme oxygenase-1 (HO-1), a 32-kDa heat shock protein, only when they have transformed into myelin-phagocytosing cells from myelinating cells (days 2–3) immediately after crush injury of rat sciatic nerves. Double immunofluorescent labelling for HO-1 and transferrin receptors revealed that HO-1-immunoreactive Schwann cells also expressed transferrin receptors suggesting activation of iron metabolism. The transient induction of HO-1 in Schwann cells may contribute to the adaptive function in an altered environment when the cells have lost contact with axons, and may play a crucial role in the ensuing regeneration.
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| Type of Medium: |
Electronic Resource
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| URL: |