Improvement with disodium cromoglycate of neutrophil phagocytosis and respiratory burst activity in a patient with hyperimmunoglobulin E syndrome
Kojima, K. ; Inoue, Y. ; Katayama, Y. ; Kataoka, M. ; Sunami, K. ; Fukuda, S. ; Sezaki, T. ; Omoto, E. ; Harada, M.
Oxford, UK : Blackwell Publishing Ltd
Published 1998
Oxford, UK : Blackwell Publishing Ltd
Published 1998
| ISSN: |
1398-9995
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|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
We report a case of hyperimmunoglobulin E syndrome (HIE) complicated by neutrophil deficiency which was successfully treated with oral administration of disodium cromoglycate. A 48-year-old Japanese man with HIE developed Streptococcus pneumoniae meningitis. Laboratory tests after the meningitis revealed persistent neutropenia (300-800/mm3) and defects of phagocytosis and bacterial killing by neutrophils. Administration of disodium cromoglycate was started, and neutrophil counts gradually increased to 1200-1600/mm3 TTie impaired neutrophil activities returned to normal. The patient improved clinically; during the 2-year treatment, he had only two brief episodes of the common cold. Disodium cromoglycate may have potential clinical use in the treatment of cases of HIE even with neutrophil deficiency.
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| Type of Medium: |
Electronic Resource
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| URL: |