Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload

Chan, W. S. ; Irwin, M. G. ; Tong, W. N. ; Lam, Y. H.

Oxford, UK : Blackwell Science Ltd
Published 1997
ISSN:
1365-2044
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
We compared the efficacy of prophylactic ephedrine infusion over fluid preloading in prevention of maternal hypotension during spinal anaesthesia for Caesarean section. Forty-six women undergoing elective Caesarean section at term were allocated randomly to receive either intravenous fluid preloading with Hartmann's solution 20 ml.kg−1 (fluid group) or prophylactic intravenous ephedrine 0.25 mgkg−1 (ephedrine group). Moderate hypotension was defined as ≥ 20% reduction in systolic blood pressure and severe hypotension as ≥ 30% reduction in systolic blood pressure. Maternal uterine circulation was measured using Doppler ultrasound in 11 parturients before and after spinal anaesthesia. There was a lower incidence of severe hypotension in the ephedrine group compared with the fluid group (35% vs. 65%, p = 0.04), although the incidence of moderate hypotension was similar. Mean umbilical venous pH was higher in the ephedrine group than in the fluid group (7.33 vs. 7.29, p = 0.02) and the number of patients shivering was lower in the ephedrine group (2 vs. 9, p = 0.02). No difference was found between pre- and postspinal uterine artery pulsatility indices in either group. We conclude that prophylactic ephedrine infusion alone is at least as good as fluid preload alone in combating the hypotension associated with spinal anaesthesia for Caesarean section.
Type of Medium:
Electronic Resource
URL:
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autor Chan, W. S.
Irwin, M. G.
Tong, W. N.
Lam, Y. H.
autorsonst Lam, Y. H.
book_url http://dx.doi.org/10.1111/j.1365-2044.1997.190-az0323.x
datenlieferant nat_lic_papers
hauptsatz hsatz_simple
identnr NLZ242283411
insertion_date 2012-04-27
issn 1365-2044
journal_name Anaesthesia
materialart 1
notes We compared the efficacy of prophylactic ephedrine infusion over fluid preloading in prevention of maternal hypotension during spinal anaesthesia for Caesarean section. Forty-six women undergoing elective Caesarean section at term were allocated randomly to receive either intravenous fluid preloading with Hartmann's solution 20 ml.kg−1 (fluid group) or prophylactic intravenous ephedrine 0.25 mgkg−1 (ephedrine group). Moderate hypotension was defined as ≥ 20% reduction in systolic blood pressure and severe hypotension as ≥ 30% reduction in systolic blood pressure. Maternal uterine circulation was measured using Doppler ultrasound in 11 parturients before and after spinal anaesthesia. There was a lower incidence of severe hypotension in the ephedrine group compared with the fluid group (35% vs. 65%, p = 0.04), although the incidence of moderate hypotension was similar. Mean umbilical venous pH was higher in the ephedrine group than in the fluid group (7.33 vs. 7.29, p = 0.02) and the number of patients shivering was lower in the ephedrine group (2 vs. 9, p = 0.02). No difference was found between pre- and postspinal uterine artery pulsatility indices in either group. We conclude that prophylactic ephedrine infusion alone is at least as good as fluid preload alone in combating the hypotension associated with spinal anaesthesia for Caesarean section.
package_name Blackwell Publishing
publikationsjahr_anzeige 1997
publikationsjahr_facette 1997
publikationsjahr_intervall 8004:1995-1999
publikationsjahr_sort 1997
publikationsort Oxford, UK
publisher Blackwell Science Ltd
reference 52 (1997), S. 0
search_space articles
shingle_author_1 Chan, W. S.
Irwin, M. G.
Tong, W. N.
Lam, Y. H.
shingle_author_2 Chan, W. S.
Irwin, M. G.
Tong, W. N.
Lam, Y. H.
shingle_author_3 Chan, W. S.
Irwin, M. G.
Tong, W. N.
Lam, Y. H.
shingle_author_4 Chan, W. S.
Irwin, M. G.
Tong, W. N.
Lam, Y. H.
shingle_catch_all_1 Chan, W. S.
Irwin, M. G.
Tong, W. N.
Lam, Y. H.
Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload
Blackwell Science Ltd
We compared the efficacy of prophylactic ephedrine infusion over fluid preloading in prevention of maternal hypotension during spinal anaesthesia for Caesarean section. Forty-six women undergoing elective Caesarean section at term were allocated randomly to receive either intravenous fluid preloading with Hartmann's solution 20 ml.kg−1 (fluid group) or prophylactic intravenous ephedrine 0.25 mgkg−1 (ephedrine group). Moderate hypotension was defined as ≥ 20% reduction in systolic blood pressure and severe hypotension as ≥ 30% reduction in systolic blood pressure. Maternal uterine circulation was measured using Doppler ultrasound in 11 parturients before and after spinal anaesthesia. There was a lower incidence of severe hypotension in the ephedrine group compared with the fluid group (35% vs. 65%, p = 0.04), although the incidence of moderate hypotension was similar. Mean umbilical venous pH was higher in the ephedrine group than in the fluid group (7.33 vs. 7.29, p = 0.02) and the number of patients shivering was lower in the ephedrine group (2 vs. 9, p = 0.02). No difference was found between pre- and postspinal uterine artery pulsatility indices in either group. We conclude that prophylactic ephedrine infusion alone is at least as good as fluid preload alone in combating the hypotension associated with spinal anaesthesia for Caesarean section.
1365-2044
13652044
shingle_catch_all_2 Chan, W. S.
Irwin, M. G.
Tong, W. N.
Lam, Y. H.
Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload
Blackwell Science Ltd
We compared the efficacy of prophylactic ephedrine infusion over fluid preloading in prevention of maternal hypotension during spinal anaesthesia for Caesarean section. Forty-six women undergoing elective Caesarean section at term were allocated randomly to receive either intravenous fluid preloading with Hartmann's solution 20 ml.kg−1 (fluid group) or prophylactic intravenous ephedrine 0.25 mgkg−1 (ephedrine group). Moderate hypotension was defined as ≥ 20% reduction in systolic blood pressure and severe hypotension as ≥ 30% reduction in systolic blood pressure. Maternal uterine circulation was measured using Doppler ultrasound in 11 parturients before and after spinal anaesthesia. There was a lower incidence of severe hypotension in the ephedrine group compared with the fluid group (35% vs. 65%, p = 0.04), although the incidence of moderate hypotension was similar. Mean umbilical venous pH was higher in the ephedrine group than in the fluid group (7.33 vs. 7.29, p = 0.02) and the number of patients shivering was lower in the ephedrine group (2 vs. 9, p = 0.02). No difference was found between pre- and postspinal uterine artery pulsatility indices in either group. We conclude that prophylactic ephedrine infusion alone is at least as good as fluid preload alone in combating the hypotension associated with spinal anaesthesia for Caesarean section.
1365-2044
13652044
shingle_catch_all_3 Chan, W. S.
Irwin, M. G.
Tong, W. N.
Lam, Y. H.
Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload
Blackwell Science Ltd
We compared the efficacy of prophylactic ephedrine infusion over fluid preloading in prevention of maternal hypotension during spinal anaesthesia for Caesarean section. Forty-six women undergoing elective Caesarean section at term were allocated randomly to receive either intravenous fluid preloading with Hartmann's solution 20 ml.kg−1 (fluid group) or prophylactic intravenous ephedrine 0.25 mgkg−1 (ephedrine group). Moderate hypotension was defined as ≥ 20% reduction in systolic blood pressure and severe hypotension as ≥ 30% reduction in systolic blood pressure. Maternal uterine circulation was measured using Doppler ultrasound in 11 parturients before and after spinal anaesthesia. There was a lower incidence of severe hypotension in the ephedrine group compared with the fluid group (35% vs. 65%, p = 0.04), although the incidence of moderate hypotension was similar. Mean umbilical venous pH was higher in the ephedrine group than in the fluid group (7.33 vs. 7.29, p = 0.02) and the number of patients shivering was lower in the ephedrine group (2 vs. 9, p = 0.02). No difference was found between pre- and postspinal uterine artery pulsatility indices in either group. We conclude that prophylactic ephedrine infusion alone is at least as good as fluid preload alone in combating the hypotension associated with spinal anaesthesia for Caesarean section.
1365-2044
13652044
shingle_catch_all_4 Chan, W. S.
Irwin, M. G.
Tong, W. N.
Lam, Y. H.
Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload
Blackwell Science Ltd
We compared the efficacy of prophylactic ephedrine infusion over fluid preloading in prevention of maternal hypotension during spinal anaesthesia for Caesarean section. Forty-six women undergoing elective Caesarean section at term were allocated randomly to receive either intravenous fluid preloading with Hartmann's solution 20 ml.kg−1 (fluid group) or prophylactic intravenous ephedrine 0.25 mgkg−1 (ephedrine group). Moderate hypotension was defined as ≥ 20% reduction in systolic blood pressure and severe hypotension as ≥ 30% reduction in systolic blood pressure. Maternal uterine circulation was measured using Doppler ultrasound in 11 parturients before and after spinal anaesthesia. There was a lower incidence of severe hypotension in the ephedrine group compared with the fluid group (35% vs. 65%, p = 0.04), although the incidence of moderate hypotension was similar. Mean umbilical venous pH was higher in the ephedrine group than in the fluid group (7.33 vs. 7.29, p = 0.02) and the number of patients shivering was lower in the ephedrine group (2 vs. 9, p = 0.02). No difference was found between pre- and postspinal uterine artery pulsatility indices in either group. We conclude that prophylactic ephedrine infusion alone is at least as good as fluid preload alone in combating the hypotension associated with spinal anaesthesia for Caesarean section.
1365-2044
13652044
shingle_title_1 Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload
shingle_title_2 Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload
shingle_title_3 Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload
shingle_title_4 Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload
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source_archive Blackwell Publishing Journal Backfiles 1879-2005
timestamp 2024-05-06T08:12:45.946Z
titel Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload
titel_suche Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload
topic WW-YZ
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