Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload
Chan, W. S. ; Irwin, M. G. ; Tong, W. N. ; Lam, Y. H.
Oxford, UK : Blackwell Science Ltd
Published 1997
Oxford, UK : Blackwell Science Ltd
Published 1997
| ISSN: |
1365-2044
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|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
We compared the efficacy of prophylactic ephedrine infusion over fluid preloading in prevention of maternal hypotension during spinal anaesthesia for Caesarean section. Forty-six women undergoing elective Caesarean section at term were allocated randomly to receive either intravenous fluid preloading with Hartmann's solution 20 ml.kg−1 (fluid group) or prophylactic intravenous ephedrine 0.25 mgkg−1 (ephedrine group). Moderate hypotension was defined as ≥ 20% reduction in systolic blood pressure and severe hypotension as ≥ 30% reduction in systolic blood pressure. Maternal uterine circulation was measured using Doppler ultrasound in 11 parturients before and after spinal anaesthesia. There was a lower incidence of severe hypotension in the ephedrine group compared with the fluid group (35% vs. 65%, p = 0.04), although the incidence of moderate hypotension was similar. Mean umbilical venous pH was higher in the ephedrine group than in the fluid group (7.33 vs. 7.29, p = 0.02) and the number of patients shivering was lower in the ephedrine group (2 vs. 9, p = 0.02). No difference was found between pre- and postspinal uterine artery pulsatility indices in either group. We conclude that prophylactic ephedrine infusion alone is at least as good as fluid preload alone in combating the hypotension associated with spinal anaesthesia for Caesarean section.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798290188507545601 |
|---|---|
| autor | Chan, W. S. Irwin, M. G. Tong, W. N. Lam, Y. H. |
| autorsonst | Lam, Y. H. |
| book_url | http://dx.doi.org/10.1111/j.1365-2044.1997.190-az0323.x |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLZ242283411 |
| insertion_date | 2012-04-27 |
| issn | 1365-2044 |
| journal_name | Anaesthesia |
| materialart | 1 |
| notes | We compared the efficacy of prophylactic ephedrine infusion over fluid preloading in prevention of maternal hypotension during spinal anaesthesia for Caesarean section. Forty-six women undergoing elective Caesarean section at term were allocated randomly to receive either intravenous fluid preloading with Hartmann's solution 20 ml.kg−1 (fluid group) or prophylactic intravenous ephedrine 0.25 mgkg−1 (ephedrine group). Moderate hypotension was defined as ≥ 20% reduction in systolic blood pressure and severe hypotension as ≥ 30% reduction in systolic blood pressure. Maternal uterine circulation was measured using Doppler ultrasound in 11 parturients before and after spinal anaesthesia. There was a lower incidence of severe hypotension in the ephedrine group compared with the fluid group (35% vs. 65%, p = 0.04), although the incidence of moderate hypotension was similar. Mean umbilical venous pH was higher in the ephedrine group than in the fluid group (7.33 vs. 7.29, p = 0.02) and the number of patients shivering was lower in the ephedrine group (2 vs. 9, p = 0.02). No difference was found between pre- and postspinal uterine artery pulsatility indices in either group. We conclude that prophylactic ephedrine infusion alone is at least as good as fluid preload alone in combating the hypotension associated with spinal anaesthesia for Caesarean section. |
| package_name | Blackwell Publishing |
| publikationsjahr_anzeige | 1997 |
| publikationsjahr_facette | 1997 |
| publikationsjahr_intervall | 8004:1995-1999 |
| publikationsjahr_sort | 1997 |
| publikationsort | Oxford, UK |
| publisher | Blackwell Science Ltd |
| reference | 52 (1997), S. 0 |
| search_space | articles |
| shingle_author_1 | Chan, W. S. Irwin, M. G. Tong, W. N. Lam, Y. H. |
| shingle_author_2 | Chan, W. S. Irwin, M. G. Tong, W. N. Lam, Y. H. |
| shingle_author_3 | Chan, W. S. Irwin, M. G. Tong, W. N. Lam, Y. H. |
| shingle_author_4 | Chan, W. S. Irwin, M. G. Tong, W. N. Lam, Y. H. |
| shingle_catch_all_1 | Chan, W. S. Irwin, M. G. Tong, W. N. Lam, Y. H. Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload Blackwell Science Ltd We compared the efficacy of prophylactic ephedrine infusion over fluid preloading in prevention of maternal hypotension during spinal anaesthesia for Caesarean section. Forty-six women undergoing elective Caesarean section at term were allocated randomly to receive either intravenous fluid preloading with Hartmann's solution 20 ml.kg−1 (fluid group) or prophylactic intravenous ephedrine 0.25 mgkg−1 (ephedrine group). Moderate hypotension was defined as ≥ 20% reduction in systolic blood pressure and severe hypotension as ≥ 30% reduction in systolic blood pressure. Maternal uterine circulation was measured using Doppler ultrasound in 11 parturients before and after spinal anaesthesia. There was a lower incidence of severe hypotension in the ephedrine group compared with the fluid group (35% vs. 65%, p = 0.04), although the incidence of moderate hypotension was similar. Mean umbilical venous pH was higher in the ephedrine group than in the fluid group (7.33 vs. 7.29, p = 0.02) and the number of patients shivering was lower in the ephedrine group (2 vs. 9, p = 0.02). No difference was found between pre- and postspinal uterine artery pulsatility indices in either group. We conclude that prophylactic ephedrine infusion alone is at least as good as fluid preload alone in combating the hypotension associated with spinal anaesthesia for Caesarean section. 1365-2044 13652044 |
| shingle_catch_all_2 | Chan, W. S. Irwin, M. G. Tong, W. N. Lam, Y. H. Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload Blackwell Science Ltd We compared the efficacy of prophylactic ephedrine infusion over fluid preloading in prevention of maternal hypotension during spinal anaesthesia for Caesarean section. Forty-six women undergoing elective Caesarean section at term were allocated randomly to receive either intravenous fluid preloading with Hartmann's solution 20 ml.kg−1 (fluid group) or prophylactic intravenous ephedrine 0.25 mgkg−1 (ephedrine group). Moderate hypotension was defined as ≥ 20% reduction in systolic blood pressure and severe hypotension as ≥ 30% reduction in systolic blood pressure. Maternal uterine circulation was measured using Doppler ultrasound in 11 parturients before and after spinal anaesthesia. There was a lower incidence of severe hypotension in the ephedrine group compared with the fluid group (35% vs. 65%, p = 0.04), although the incidence of moderate hypotension was similar. Mean umbilical venous pH was higher in the ephedrine group than in the fluid group (7.33 vs. 7.29, p = 0.02) and the number of patients shivering was lower in the ephedrine group (2 vs. 9, p = 0.02). No difference was found between pre- and postspinal uterine artery pulsatility indices in either group. We conclude that prophylactic ephedrine infusion alone is at least as good as fluid preload alone in combating the hypotension associated with spinal anaesthesia for Caesarean section. 1365-2044 13652044 |
| shingle_catch_all_3 | Chan, W. S. Irwin, M. G. Tong, W. N. Lam, Y. H. Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload Blackwell Science Ltd We compared the efficacy of prophylactic ephedrine infusion over fluid preloading in prevention of maternal hypotension during spinal anaesthesia for Caesarean section. Forty-six women undergoing elective Caesarean section at term were allocated randomly to receive either intravenous fluid preloading with Hartmann's solution 20 ml.kg−1 (fluid group) or prophylactic intravenous ephedrine 0.25 mgkg−1 (ephedrine group). Moderate hypotension was defined as ≥ 20% reduction in systolic blood pressure and severe hypotension as ≥ 30% reduction in systolic blood pressure. Maternal uterine circulation was measured using Doppler ultrasound in 11 parturients before and after spinal anaesthesia. There was a lower incidence of severe hypotension in the ephedrine group compared with the fluid group (35% vs. 65%, p = 0.04), although the incidence of moderate hypotension was similar. Mean umbilical venous pH was higher in the ephedrine group than in the fluid group (7.33 vs. 7.29, p = 0.02) and the number of patients shivering was lower in the ephedrine group (2 vs. 9, p = 0.02). No difference was found between pre- and postspinal uterine artery pulsatility indices in either group. We conclude that prophylactic ephedrine infusion alone is at least as good as fluid preload alone in combating the hypotension associated with spinal anaesthesia for Caesarean section. 1365-2044 13652044 |
| shingle_catch_all_4 | Chan, W. S. Irwin, M. G. Tong, W. N. Lam, Y. H. Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload Blackwell Science Ltd We compared the efficacy of prophylactic ephedrine infusion over fluid preloading in prevention of maternal hypotension during spinal anaesthesia for Caesarean section. Forty-six women undergoing elective Caesarean section at term were allocated randomly to receive either intravenous fluid preloading with Hartmann's solution 20 ml.kg−1 (fluid group) or prophylactic intravenous ephedrine 0.25 mgkg−1 (ephedrine group). Moderate hypotension was defined as ≥ 20% reduction in systolic blood pressure and severe hypotension as ≥ 30% reduction in systolic blood pressure. Maternal uterine circulation was measured using Doppler ultrasound in 11 parturients before and after spinal anaesthesia. There was a lower incidence of severe hypotension in the ephedrine group compared with the fluid group (35% vs. 65%, p = 0.04), although the incidence of moderate hypotension was similar. Mean umbilical venous pH was higher in the ephedrine group than in the fluid group (7.33 vs. 7.29, p = 0.02) and the number of patients shivering was lower in the ephedrine group (2 vs. 9, p = 0.02). No difference was found between pre- and postspinal uterine artery pulsatility indices in either group. We conclude that prophylactic ephedrine infusion alone is at least as good as fluid preload alone in combating the hypotension associated with spinal anaesthesia for Caesarean section. 1365-2044 13652044 |
| shingle_title_1 | Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload |
| shingle_title_2 | Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload |
| shingle_title_3 | Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload |
| shingle_title_4 | Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload |
| sigel_instance_filter | dkfz geomar wilbert ipn albert |
| source_archive | Blackwell Publishing Journal Backfiles 1879-2005 |
| timestamp | 2024-05-06T08:12:45.946Z |
| titel | Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload |
| titel_suche | Prevention of hypotension during spinal anaesthesia for Caesarean section: ephedrine infusion versus fluid preload |
| topic | WW-YZ |
| uid | nat_lic_papers_NLZ242283411 |