What is the role of serology in assessing Helicobacter pylori eradication?
Bergey, B. ; Marchildon, P. ; Peacock, J. ; Mégraud, F.
Oxford, UK : Blackwell Science Ltd
Published 2003
Oxford, UK : Blackwell Science Ltd
Published 2003
| ISSN: |
1365-2036
|
|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
|
| Topics: |
Medicine
|
| Notes: |
Aim : To assess the decline in Helicobacter pylori antibodies after eradication of infection.Methods : The H. pylori status was determined at entry (D0) by culture and histology performed on antral biopsies and after eradication treatment at day 42 (day 42) and after 6 months (M6) by the 13C-urea breath test. The EIA kits used to determine the anti-H. pylori antibody titre were HM-CAP (immunoglobulin-G) and PP-CAP (immunoglobulin-A) kits (Enteric Products, Inc.) and Pyloriset EIA-G (Orion Diagnostica).Results : Ninety-three patients were included. For 82 patients who were successfully treated, no kit was sufficiently accurate at D42 to show eradication. The antibody titre decreased for HM-CAP, PP-CAP and Pyloriset EIA-G by a mean of 35.6%, 41.2% and 64.7% between D0 and M6, respectively. According to the cut-off values defined by the manufacturers, 8.5% (PP-CAP, Pyloriset EIA-G) and 9.7% (HM-CAP) of the patients became H. pylori negative at M6. Using a 25% decrease in antibody titre between D0 and M6 as a threshold for H. pylori eradication, specificity was 100% for HM-CAP, 89.9% for Pyloriset EIA-G and 100% for PP-CAP, whereas the sensitivity was 76.8%, 98.8% and 72%, respectively.Conclusion : An antibody titre decrease of 25% at M6 was found to be accurate in confirming H. pylori eradication.
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798290074113146880 |
|---|---|
| autor | Bergey, B. Marchildon, P. Peacock, J. Mégraud, F. |
| autorsonst | Mégraud, F. |
| book_url | http://dx.doi.org/10.1046/j.1365-2036.2003.01716.x |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLZ242201059 |
| insertion_date | 2012-04-27 |
| issn | 1365-2036 |
| journal_name | Alimentary pharmacology & therapeutics |
| materialart | 1 |
| notes | Aim : To assess the decline in Helicobacter pylori antibodies after eradication of infection.Methods : The H. pylori status was determined at entry (D0) by culture and histology performed on antral biopsies and after eradication treatment at day 42 (day 42) and after 6 months (M6) by the 13C-urea breath test. The EIA kits used to determine the anti-H. pylori antibody titre were HM-CAP (immunoglobulin-G) and PP-CAP (immunoglobulin-A) kits (Enteric Products, Inc.) and Pyloriset EIA-G (Orion Diagnostica).Results : Ninety-three patients were included. For 82 patients who were successfully treated, no kit was sufficiently accurate at D42 to show eradication. The antibody titre decreased for HM-CAP, PP-CAP and Pyloriset EIA-G by a mean of 35.6%, 41.2% and 64.7% between D0 and M6, respectively. According to the cut-off values defined by the manufacturers, 8.5% (PP-CAP, Pyloriset EIA-G) and 9.7% (HM-CAP) of the patients became H. pylori negative at M6. Using a 25% decrease in antibody titre between D0 and M6 as a threshold for H. pylori eradication, specificity was 100% for HM-CAP, 89.9% for Pyloriset EIA-G and 100% for PP-CAP, whereas the sensitivity was 76.8%, 98.8% and 72%, respectively.Conclusion : An antibody titre decrease of 25% at M6 was found to be accurate in confirming H. pylori eradication. |
| package_name | Blackwell Publishing |
| publikationsjahr_anzeige | 2003 |
| publikationsjahr_facette | 2003 |
| publikationsjahr_intervall | 7999:2000-2004 |
| publikationsjahr_sort | 2003 |
| publikationsort | Oxford, UK |
| publisher | Blackwell Science Ltd |
| reference | 18 (2003), S. 0 |
| search_space | articles |
| shingle_author_1 | Bergey, B. Marchildon, P. Peacock, J. Mégraud, F. |
| shingle_author_2 | Bergey, B. Marchildon, P. Peacock, J. Mégraud, F. |
| shingle_author_3 | Bergey, B. Marchildon, P. Peacock, J. Mégraud, F. |
| shingle_author_4 | Bergey, B. Marchildon, P. Peacock, J. Mégraud, F. |
| shingle_catch_all_1 | Bergey, B. Marchildon, P. Peacock, J. Mégraud, F. What is the role of serology in assessing Helicobacter pylori eradication? Blackwell Science Ltd Aim : To assess the decline in Helicobacter pylori antibodies after eradication of infection.Methods : The H. pylori status was determined at entry (D0) by culture and histology performed on antral biopsies and after eradication treatment at day 42 (day 42) and after 6 months (M6) by the 13C-urea breath test. The EIA kits used to determine the anti-H. pylori antibody titre were HM-CAP (immunoglobulin-G) and PP-CAP (immunoglobulin-A) kits (Enteric Products, Inc.) and Pyloriset EIA-G (Orion Diagnostica).Results : Ninety-three patients were included. For 82 patients who were successfully treated, no kit was sufficiently accurate at D42 to show eradication. The antibody titre decreased for HM-CAP, PP-CAP and Pyloriset EIA-G by a mean of 35.6%, 41.2% and 64.7% between D0 and M6, respectively. According to the cut-off values defined by the manufacturers, 8.5% (PP-CAP, Pyloriset EIA-G) and 9.7% (HM-CAP) of the patients became H. pylori negative at M6. Using a 25% decrease in antibody titre between D0 and M6 as a threshold for H. pylori eradication, specificity was 100% for HM-CAP, 89.9% for Pyloriset EIA-G and 100% for PP-CAP, whereas the sensitivity was 76.8%, 98.8% and 72%, respectively.Conclusion : An antibody titre decrease of 25% at M6 was found to be accurate in confirming H. pylori eradication. 1365-2036 13652036 |
| shingle_catch_all_2 | Bergey, B. Marchildon, P. Peacock, J. Mégraud, F. What is the role of serology in assessing Helicobacter pylori eradication? Blackwell Science Ltd Aim : To assess the decline in Helicobacter pylori antibodies after eradication of infection.Methods : The H. pylori status was determined at entry (D0) by culture and histology performed on antral biopsies and after eradication treatment at day 42 (day 42) and after 6 months (M6) by the 13C-urea breath test. The EIA kits used to determine the anti-H. pylori antibody titre were HM-CAP (immunoglobulin-G) and PP-CAP (immunoglobulin-A) kits (Enteric Products, Inc.) and Pyloriset EIA-G (Orion Diagnostica).Results : Ninety-three patients were included. For 82 patients who were successfully treated, no kit was sufficiently accurate at D42 to show eradication. The antibody titre decreased for HM-CAP, PP-CAP and Pyloriset EIA-G by a mean of 35.6%, 41.2% and 64.7% between D0 and M6, respectively. According to the cut-off values defined by the manufacturers, 8.5% (PP-CAP, Pyloriset EIA-G) and 9.7% (HM-CAP) of the patients became H. pylori negative at M6. Using a 25% decrease in antibody titre between D0 and M6 as a threshold for H. pylori eradication, specificity was 100% for HM-CAP, 89.9% for Pyloriset EIA-G and 100% for PP-CAP, whereas the sensitivity was 76.8%, 98.8% and 72%, respectively.Conclusion : An antibody titre decrease of 25% at M6 was found to be accurate in confirming H. pylori eradication. 1365-2036 13652036 |
| shingle_catch_all_3 | Bergey, B. Marchildon, P. Peacock, J. Mégraud, F. What is the role of serology in assessing Helicobacter pylori eradication? Blackwell Science Ltd Aim : To assess the decline in Helicobacter pylori antibodies after eradication of infection.Methods : The H. pylori status was determined at entry (D0) by culture and histology performed on antral biopsies and after eradication treatment at day 42 (day 42) and after 6 months (M6) by the 13C-urea breath test. The EIA kits used to determine the anti-H. pylori antibody titre were HM-CAP (immunoglobulin-G) and PP-CAP (immunoglobulin-A) kits (Enteric Products, Inc.) and Pyloriset EIA-G (Orion Diagnostica).Results : Ninety-three patients were included. For 82 patients who were successfully treated, no kit was sufficiently accurate at D42 to show eradication. The antibody titre decreased for HM-CAP, PP-CAP and Pyloriset EIA-G by a mean of 35.6%, 41.2% and 64.7% between D0 and M6, respectively. According to the cut-off values defined by the manufacturers, 8.5% (PP-CAP, Pyloriset EIA-G) and 9.7% (HM-CAP) of the patients became H. pylori negative at M6. Using a 25% decrease in antibody titre between D0 and M6 as a threshold for H. pylori eradication, specificity was 100% for HM-CAP, 89.9% for Pyloriset EIA-G and 100% for PP-CAP, whereas the sensitivity was 76.8%, 98.8% and 72%, respectively.Conclusion : An antibody titre decrease of 25% at M6 was found to be accurate in confirming H. pylori eradication. 1365-2036 13652036 |
| shingle_catch_all_4 | Bergey, B. Marchildon, P. Peacock, J. Mégraud, F. What is the role of serology in assessing Helicobacter pylori eradication? Blackwell Science Ltd Aim : To assess the decline in Helicobacter pylori antibodies after eradication of infection.Methods : The H. pylori status was determined at entry (D0) by culture and histology performed on antral biopsies and after eradication treatment at day 42 (day 42) and after 6 months (M6) by the 13C-urea breath test. The EIA kits used to determine the anti-H. pylori antibody titre were HM-CAP (immunoglobulin-G) and PP-CAP (immunoglobulin-A) kits (Enteric Products, Inc.) and Pyloriset EIA-G (Orion Diagnostica).Results : Ninety-three patients were included. For 82 patients who were successfully treated, no kit was sufficiently accurate at D42 to show eradication. The antibody titre decreased for HM-CAP, PP-CAP and Pyloriset EIA-G by a mean of 35.6%, 41.2% and 64.7% between D0 and M6, respectively. According to the cut-off values defined by the manufacturers, 8.5% (PP-CAP, Pyloriset EIA-G) and 9.7% (HM-CAP) of the patients became H. pylori negative at M6. Using a 25% decrease in antibody titre between D0 and M6 as a threshold for H. pylori eradication, specificity was 100% for HM-CAP, 89.9% for Pyloriset EIA-G and 100% for PP-CAP, whereas the sensitivity was 76.8%, 98.8% and 72%, respectively.Conclusion : An antibody titre decrease of 25% at M6 was found to be accurate in confirming H. pylori eradication. 1365-2036 13652036 |
| shingle_title_1 | What is the role of serology in assessing Helicobacter pylori eradication? |
| shingle_title_2 | What is the role of serology in assessing Helicobacter pylori eradication? |
| shingle_title_3 | What is the role of serology in assessing Helicobacter pylori eradication? |
| shingle_title_4 | What is the role of serology in assessing Helicobacter pylori eradication? |
| sigel_instance_filter | dkfz geomar wilbert ipn albert |
| source_archive | Blackwell Publishing Journal Backfiles 1879-2005 |
| timestamp | 2024-05-06T08:10:56.559Z |
| titel | What is the role of serology in assessing Helicobacter pylori eradication? |
| titel_suche | What is the role of serology in assessing Helicobacter pylori eradication? |
| topic | WW-YZ |
| uid | nat_lic_papers_NLZ242201059 |