The association between admission for poisoning with paracetamol or other weak analgesics and subsequent admission for psychiatric disorder: a Danish nationwide case–control study
JEPSEN, P. ; QIN, P. ; NØRGÅRD, B. ; AGERBO, E. ; MORTENSEN, P. B. ; VILSTRUP, H. ; SØRENSEN, H. T.
Oxford, UK : Blackwell Science Ltd
Published 2005
Oxford, UK : Blackwell Science Ltd
Published 2005
| ISSN: |
1365-2036
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|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
Background : Many cases of paracetamol poisoning are with suicidal intent, but the association between paracetamol poisoning and subsequent psychiatric disorder is unknown.Aim : To examine the association between poisoning with paracetamol or other weak analgesics and subsequent psychiatric disorder.Methods : The study was set in a nested case–control design and based on nationwide Danish registers. We identified all patients diagnosed with schizophrenia, affective disorder or eating disorder in 1994–1998 and matched population controls. We estimated the relative risk of these psychiatric disorders after admission for paracetamol or nonparacetamol poisoning, adjusting for income, employment and marital status.Results : We included 12 603 cases with psychiatric disorder, and 1.2% had a diagnosis of poisoning compared with 0.2% of the 252 060 matched population controls. Compared with those with no diagnoses of weak analgesic poisoning, the risk of schizophrenia increased 3.9-fold after paracetamol poisoning, and 2.0-fold after nonparacetamol poisoning. The risk of affective disorder increased 12.2-fold after paracetamol poisoning and 2.6-fold after nonparacetamol poisoning. The risk of eating disorder increased 5.0-fold after paracetamol poisoning, and 2.2-fold after nonparacetamol poisoning. The risk of a diagnosis of psychiatric disorder was very high immediately after poisoning and remained increased for more than 10 years.Conclusions : Paracetamol poisoning is a strong risk marker for psychiatric disorder, particularly affective disorders.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798290073248071680 |
|---|---|
| autor | JEPSEN, P. QIN, P. NØRGÅRD, B. AGERBO, E. MORTENSEN, P. B. VILSTRUP, H. SØRENSEN, H. T. |
| autorsonst | AGERBO, E. MORTENSEN, P. B. VILSTRUP, H. SØRENSEN, H. T. |
| book_url | http://dx.doi.org/10.1111/j.1365-2036.2005.02638.x |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLZ242192017 |
| insertion_date | 2012-04-27 |
| issn | 1365-2036 |
| journal_name | Alimentary pharmacology & therapeutics |
| materialart | 1 |
| notes | Background : Many cases of paracetamol poisoning are with suicidal intent, but the association between paracetamol poisoning and subsequent psychiatric disorder is unknown.Aim : To examine the association between poisoning with paracetamol or other weak analgesics and subsequent psychiatric disorder.Methods : The study was set in a nested case–control design and based on nationwide Danish registers. We identified all patients diagnosed with schizophrenia, affective disorder or eating disorder in 1994–1998 and matched population controls. We estimated the relative risk of these psychiatric disorders after admission for paracetamol or nonparacetamol poisoning, adjusting for income, employment and marital status.Results : We included 12 603 cases with psychiatric disorder, and 1.2% had a diagnosis of poisoning compared with 0.2% of the 252 060 matched population controls. Compared with those with no diagnoses of weak analgesic poisoning, the risk of schizophrenia increased 3.9-fold after paracetamol poisoning, and 2.0-fold after nonparacetamol poisoning. The risk of affective disorder increased 12.2-fold after paracetamol poisoning and 2.6-fold after nonparacetamol poisoning. The risk of eating disorder increased 5.0-fold after paracetamol poisoning, and 2.2-fold after nonparacetamol poisoning. The risk of a diagnosis of psychiatric disorder was very high immediately after poisoning and remained increased for more than 10 years.Conclusions : Paracetamol poisoning is a strong risk marker for psychiatric disorder, particularly affective disorders. |
| package_name | Blackwell Publishing |
| publikationsjahr_anzeige | 2005 |
| publikationsjahr_facette | 2005 |
| publikationsjahr_intervall | 7994:2005-2009 |
| publikationsjahr_sort | 2005 |
| publikationsort | Oxford, UK |
| publisher | Blackwell Science Ltd |
| reference | 22 (2005), S. 0 |
| search_space | articles |
| shingle_author_1 | JEPSEN, P. QIN, P. NØRGÅRD, B. AGERBO, E. MORTENSEN, P. B. VILSTRUP, H. SØRENSEN, H. T. |
| shingle_author_2 | JEPSEN, P. QIN, P. NØRGÅRD, B. AGERBO, E. MORTENSEN, P. B. VILSTRUP, H. SØRENSEN, H. T. |
| shingle_author_3 | JEPSEN, P. QIN, P. NØRGÅRD, B. AGERBO, E. MORTENSEN, P. B. VILSTRUP, H. SØRENSEN, H. T. |
| shingle_author_4 | JEPSEN, P. QIN, P. NØRGÅRD, B. AGERBO, E. MORTENSEN, P. B. VILSTRUP, H. SØRENSEN, H. T. |
| shingle_catch_all_1 | JEPSEN, P. QIN, P. NØRGÅRD, B. AGERBO, E. MORTENSEN, P. B. VILSTRUP, H. SØRENSEN, H. T. The association between admission for poisoning with paracetamol or other weak analgesics and subsequent admission for psychiatric disorder: a Danish nationwide case–control study Blackwell Science Ltd Background : Many cases of paracetamol poisoning are with suicidal intent, but the association between paracetamol poisoning and subsequent psychiatric disorder is unknown.Aim : To examine the association between poisoning with paracetamol or other weak analgesics and subsequent psychiatric disorder.Methods : The study was set in a nested case–control design and based on nationwide Danish registers. We identified all patients diagnosed with schizophrenia, affective disorder or eating disorder in 1994–1998 and matched population controls. We estimated the relative risk of these psychiatric disorders after admission for paracetamol or nonparacetamol poisoning, adjusting for income, employment and marital status.Results : We included 12 603 cases with psychiatric disorder, and 1.2% had a diagnosis of poisoning compared with 0.2% of the 252 060 matched population controls. Compared with those with no diagnoses of weak analgesic poisoning, the risk of schizophrenia increased 3.9-fold after paracetamol poisoning, and 2.0-fold after nonparacetamol poisoning. The risk of affective disorder increased 12.2-fold after paracetamol poisoning and 2.6-fold after nonparacetamol poisoning. The risk of eating disorder increased 5.0-fold after paracetamol poisoning, and 2.2-fold after nonparacetamol poisoning. The risk of a diagnosis of psychiatric disorder was very high immediately after poisoning and remained increased for more than 10 years.Conclusions : Paracetamol poisoning is a strong risk marker for psychiatric disorder, particularly affective disorders. 1365-2036 13652036 |
| shingle_catch_all_2 | JEPSEN, P. QIN, P. NØRGÅRD, B. AGERBO, E. MORTENSEN, P. B. VILSTRUP, H. SØRENSEN, H. T. The association between admission for poisoning with paracetamol or other weak analgesics and subsequent admission for psychiatric disorder: a Danish nationwide case–control study Blackwell Science Ltd Background : Many cases of paracetamol poisoning are with suicidal intent, but the association between paracetamol poisoning and subsequent psychiatric disorder is unknown.Aim : To examine the association between poisoning with paracetamol or other weak analgesics and subsequent psychiatric disorder.Methods : The study was set in a nested case–control design and based on nationwide Danish registers. We identified all patients diagnosed with schizophrenia, affective disorder or eating disorder in 1994–1998 and matched population controls. We estimated the relative risk of these psychiatric disorders after admission for paracetamol or nonparacetamol poisoning, adjusting for income, employment and marital status.Results : We included 12 603 cases with psychiatric disorder, and 1.2% had a diagnosis of poisoning compared with 0.2% of the 252 060 matched population controls. Compared with those with no diagnoses of weak analgesic poisoning, the risk of schizophrenia increased 3.9-fold after paracetamol poisoning, and 2.0-fold after nonparacetamol poisoning. The risk of affective disorder increased 12.2-fold after paracetamol poisoning and 2.6-fold after nonparacetamol poisoning. The risk of eating disorder increased 5.0-fold after paracetamol poisoning, and 2.2-fold after nonparacetamol poisoning. The risk of a diagnosis of psychiatric disorder was very high immediately after poisoning and remained increased for more than 10 years.Conclusions : Paracetamol poisoning is a strong risk marker for psychiatric disorder, particularly affective disorders. 1365-2036 13652036 |
| shingle_catch_all_3 | JEPSEN, P. QIN, P. NØRGÅRD, B. AGERBO, E. MORTENSEN, P. B. VILSTRUP, H. SØRENSEN, H. T. The association between admission for poisoning with paracetamol or other weak analgesics and subsequent admission for psychiatric disorder: a Danish nationwide case–control study Blackwell Science Ltd Background : Many cases of paracetamol poisoning are with suicidal intent, but the association between paracetamol poisoning and subsequent psychiatric disorder is unknown.Aim : To examine the association between poisoning with paracetamol or other weak analgesics and subsequent psychiatric disorder.Methods : The study was set in a nested case–control design and based on nationwide Danish registers. We identified all patients diagnosed with schizophrenia, affective disorder or eating disorder in 1994–1998 and matched population controls. We estimated the relative risk of these psychiatric disorders after admission for paracetamol or nonparacetamol poisoning, adjusting for income, employment and marital status.Results : We included 12 603 cases with psychiatric disorder, and 1.2% had a diagnosis of poisoning compared with 0.2% of the 252 060 matched population controls. Compared with those with no diagnoses of weak analgesic poisoning, the risk of schizophrenia increased 3.9-fold after paracetamol poisoning, and 2.0-fold after nonparacetamol poisoning. The risk of affective disorder increased 12.2-fold after paracetamol poisoning and 2.6-fold after nonparacetamol poisoning. The risk of eating disorder increased 5.0-fold after paracetamol poisoning, and 2.2-fold after nonparacetamol poisoning. The risk of a diagnosis of psychiatric disorder was very high immediately after poisoning and remained increased for more than 10 years.Conclusions : Paracetamol poisoning is a strong risk marker for psychiatric disorder, particularly affective disorders. 1365-2036 13652036 |
| shingle_catch_all_4 | JEPSEN, P. QIN, P. NØRGÅRD, B. AGERBO, E. MORTENSEN, P. B. VILSTRUP, H. SØRENSEN, H. T. The association between admission for poisoning with paracetamol or other weak analgesics and subsequent admission for psychiatric disorder: a Danish nationwide case–control study Blackwell Science Ltd Background : Many cases of paracetamol poisoning are with suicidal intent, but the association between paracetamol poisoning and subsequent psychiatric disorder is unknown.Aim : To examine the association between poisoning with paracetamol or other weak analgesics and subsequent psychiatric disorder.Methods : The study was set in a nested case–control design and based on nationwide Danish registers. We identified all patients diagnosed with schizophrenia, affective disorder or eating disorder in 1994–1998 and matched population controls. We estimated the relative risk of these psychiatric disorders after admission for paracetamol or nonparacetamol poisoning, adjusting for income, employment and marital status.Results : We included 12 603 cases with psychiatric disorder, and 1.2% had a diagnosis of poisoning compared with 0.2% of the 252 060 matched population controls. Compared with those with no diagnoses of weak analgesic poisoning, the risk of schizophrenia increased 3.9-fold after paracetamol poisoning, and 2.0-fold after nonparacetamol poisoning. The risk of affective disorder increased 12.2-fold after paracetamol poisoning and 2.6-fold after nonparacetamol poisoning. The risk of eating disorder increased 5.0-fold after paracetamol poisoning, and 2.2-fold after nonparacetamol poisoning. The risk of a diagnosis of psychiatric disorder was very high immediately after poisoning and remained increased for more than 10 years.Conclusions : Paracetamol poisoning is a strong risk marker for psychiatric disorder, particularly affective disorders. 1365-2036 13652036 |
| shingle_title_1 | The association between admission for poisoning with paracetamol or other weak analgesics and subsequent admission for psychiatric disorder: a Danish nationwide case–control study |
| shingle_title_2 | The association between admission for poisoning with paracetamol or other weak analgesics and subsequent admission for psychiatric disorder: a Danish nationwide case–control study |
| shingle_title_3 | The association between admission for poisoning with paracetamol or other weak analgesics and subsequent admission for psychiatric disorder: a Danish nationwide case–control study |
| shingle_title_4 | The association between admission for poisoning with paracetamol or other weak analgesics and subsequent admission for psychiatric disorder: a Danish nationwide case–control study |
| sigel_instance_filter | dkfz geomar wilbert ipn albert |
| source_archive | Blackwell Publishing Journal Backfiles 1879-2005 |
| timestamp | 2024-05-06T08:10:55.562Z |
| titel | The association between admission for poisoning with paracetamol or other weak analgesics and subsequent admission for psychiatric disorder: a Danish nationwide case–control study |
| titel_suche | The association between admission for poisoning with paracetamol or other weak analgesics and subsequent admission for psychiatric disorder: a Danish nationwide case–control study |
| topic | WW-YZ |
| uid | nat_lic_papers_NLZ242192017 |