Phenotypic Characterization of Splenic T Cells from Mice Infected with Plasmodium chabaudi chabaudi
| ISSN: |
1365-3083
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|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
T cells from spleens of mice infected with the erythrocytic stages of Plasmodium chabaudi chabaudi have been analysed with respect to their expression of surface molecules CD3, CD4 and CDS and T-cell receptor (TCR)αβ and γδ. The majority of T cells from infected mice were αβTCR +. However, there was an increase of approximately 8–10-fold in the proportion and total number of γδ T cells. Immunocytochemical analysis of sections of spleens taken from infected C57BL/6 mice during a primary infection showed that this increase took place particularly in the non-lymphoid areas. Within the αβ TCR+ T-cell population, both CD4+ T cells and CD8+ T cells were represented in proportions similar to those observed in normal uninfected mice. Stimulation of splenic T cells from infected mice with P. chabaudi-infected erythrocytes in vitro resulted ina blasted cell population composed predominantly of αβTTCR+ T cells with no preferential expansion of γβTCR+ T cells. There was no evidence of superantigen-like stimulation of T cells bearing particular Vβ chains of the TCR. The representation of the different Vβ chains within the population was not significantly different from that seen in uninfected mice.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798290237307224064 |
|---|---|
| autor | LANGHORNE, J. PELLS, S. EICHMANN, K. |
| book_url | http://dx.doi.org/10.1111/j.1365-3083.1993.tb03235.x |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLZ241948916 |
| insertion_date | 2012-04-27 |
| issn | 1365-3083 |
| journal_name | Scandinavian journal of immunology |
| materialart | 1 |
| notes | T cells from spleens of mice infected with the erythrocytic stages of Plasmodium chabaudi chabaudi have been analysed with respect to their expression of surface molecules CD3, CD4 and CDS and T-cell receptor (TCR)αβ and γδ. The majority of T cells from infected mice were αβTCR +. However, there was an increase of approximately 8–10-fold in the proportion and total number of γδ T cells. Immunocytochemical analysis of sections of spleens taken from infected C57BL/6 mice during a primary infection showed that this increase took place particularly in the non-lymphoid areas. Within the αβ TCR+ T-cell population, both CD4+ T cells and CD8+ T cells were represented in proportions similar to those observed in normal uninfected mice. Stimulation of splenic T cells from infected mice with P. chabaudi-infected erythrocytes in vitro resulted ina blasted cell population composed predominantly of αβTTCR+ T cells with no preferential expansion of γβTCR+ T cells. There was no evidence of superantigen-like stimulation of T cells bearing particular Vβ chains of the TCR. The representation of the different Vβ chains within the population was not significantly different from that seen in uninfected mice. |
| package_name | Blackwell Publishing |
| publikationsjahr_anzeige | 1993 |
| publikationsjahr_facette | 1993 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1993 |
| publikationsort | Oxford, UK |
| publisher | Blackwell Publishing Ltd |
| reference | 38 (1993), S. 0 |
| search_space | articles |
| shingle_author_1 | LANGHORNE, J. PELLS, S. EICHMANN, K. |
| shingle_author_2 | LANGHORNE, J. PELLS, S. EICHMANN, K. |
| shingle_author_3 | LANGHORNE, J. PELLS, S. EICHMANN, K. |
| shingle_author_4 | LANGHORNE, J. PELLS, S. EICHMANN, K. |
| shingle_catch_all_1 | LANGHORNE, J. PELLS, S. EICHMANN, K. Phenotypic Characterization of Splenic T Cells from Mice Infected with Plasmodium chabaudi chabaudi Blackwell Publishing Ltd T cells from spleens of mice infected with the erythrocytic stages of Plasmodium chabaudi chabaudi have been analysed with respect to their expression of surface molecules CD3, CD4 and CDS and T-cell receptor (TCR)αβ and γδ. The majority of T cells from infected mice were αβTCR +. However, there was an increase of approximately 8–10-fold in the proportion and total number of γδ T cells. Immunocytochemical analysis of sections of spleens taken from infected C57BL/6 mice during a primary infection showed that this increase took place particularly in the non-lymphoid areas. Within the αβ TCR+ T-cell population, both CD4+ T cells and CD8+ T cells were represented in proportions similar to those observed in normal uninfected mice. Stimulation of splenic T cells from infected mice with P. chabaudi-infected erythrocytes in vitro resulted ina blasted cell population composed predominantly of αβTTCR+ T cells with no preferential expansion of γβTCR+ T cells. There was no evidence of superantigen-like stimulation of T cells bearing particular Vβ chains of the TCR. The representation of the different Vβ chains within the population was not significantly different from that seen in uninfected mice. 1365-3083 13653083 |
| shingle_catch_all_2 | LANGHORNE, J. PELLS, S. EICHMANN, K. Phenotypic Characterization of Splenic T Cells from Mice Infected with Plasmodium chabaudi chabaudi Blackwell Publishing Ltd T cells from spleens of mice infected with the erythrocytic stages of Plasmodium chabaudi chabaudi have been analysed with respect to their expression of surface molecules CD3, CD4 and CDS and T-cell receptor (TCR)αβ and γδ. The majority of T cells from infected mice were αβTCR +. However, there was an increase of approximately 8–10-fold in the proportion and total number of γδ T cells. Immunocytochemical analysis of sections of spleens taken from infected C57BL/6 mice during a primary infection showed that this increase took place particularly in the non-lymphoid areas. Within the αβ TCR+ T-cell population, both CD4+ T cells and CD8+ T cells were represented in proportions similar to those observed in normal uninfected mice. Stimulation of splenic T cells from infected mice with P. chabaudi-infected erythrocytes in vitro resulted ina blasted cell population composed predominantly of αβTTCR+ T cells with no preferential expansion of γβTCR+ T cells. There was no evidence of superantigen-like stimulation of T cells bearing particular Vβ chains of the TCR. The representation of the different Vβ chains within the population was not significantly different from that seen in uninfected mice. 1365-3083 13653083 |
| shingle_catch_all_3 | LANGHORNE, J. PELLS, S. EICHMANN, K. Phenotypic Characterization of Splenic T Cells from Mice Infected with Plasmodium chabaudi chabaudi Blackwell Publishing Ltd T cells from spleens of mice infected with the erythrocytic stages of Plasmodium chabaudi chabaudi have been analysed with respect to their expression of surface molecules CD3, CD4 and CDS and T-cell receptor (TCR)αβ and γδ. The majority of T cells from infected mice were αβTCR +. However, there was an increase of approximately 8–10-fold in the proportion and total number of γδ T cells. Immunocytochemical analysis of sections of spleens taken from infected C57BL/6 mice during a primary infection showed that this increase took place particularly in the non-lymphoid areas. Within the αβ TCR+ T-cell population, both CD4+ T cells and CD8+ T cells were represented in proportions similar to those observed in normal uninfected mice. Stimulation of splenic T cells from infected mice with P. chabaudi-infected erythrocytes in vitro resulted ina blasted cell population composed predominantly of αβTTCR+ T cells with no preferential expansion of γβTCR+ T cells. There was no evidence of superantigen-like stimulation of T cells bearing particular Vβ chains of the TCR. The representation of the different Vβ chains within the population was not significantly different from that seen in uninfected mice. 1365-3083 13653083 |
| shingle_catch_all_4 | LANGHORNE, J. PELLS, S. EICHMANN, K. Phenotypic Characterization of Splenic T Cells from Mice Infected with Plasmodium chabaudi chabaudi Blackwell Publishing Ltd T cells from spleens of mice infected with the erythrocytic stages of Plasmodium chabaudi chabaudi have been analysed with respect to their expression of surface molecules CD3, CD4 and CDS and T-cell receptor (TCR)αβ and γδ. The majority of T cells from infected mice were αβTCR +. However, there was an increase of approximately 8–10-fold in the proportion and total number of γδ T cells. Immunocytochemical analysis of sections of spleens taken from infected C57BL/6 mice during a primary infection showed that this increase took place particularly in the non-lymphoid areas. Within the αβ TCR+ T-cell population, both CD4+ T cells and CD8+ T cells were represented in proportions similar to those observed in normal uninfected mice. Stimulation of splenic T cells from infected mice with P. chabaudi-infected erythrocytes in vitro resulted ina blasted cell population composed predominantly of αβTTCR+ T cells with no preferential expansion of γβTCR+ T cells. There was no evidence of superantigen-like stimulation of T cells bearing particular Vβ chains of the TCR. The representation of the different Vβ chains within the population was not significantly different from that seen in uninfected mice. 1365-3083 13653083 |
| shingle_title_1 | Phenotypic Characterization of Splenic T Cells from Mice Infected with Plasmodium chabaudi chabaudi |
| shingle_title_2 | Phenotypic Characterization of Splenic T Cells from Mice Infected with Plasmodium chabaudi chabaudi |
| shingle_title_3 | Phenotypic Characterization of Splenic T Cells from Mice Infected with Plasmodium chabaudi chabaudi |
| shingle_title_4 | Phenotypic Characterization of Splenic T Cells from Mice Infected with Plasmodium chabaudi chabaudi |
| sigel_instance_filter | dkfz geomar wilbert ipn albert |
| source_archive | Blackwell Publishing Journal Backfiles 1879-2005 |
| timestamp | 2024-05-06T08:13:30.001Z |
| titel | Phenotypic Characterization of Splenic T Cells from Mice Infected with Plasmodium chabaudi chabaudi |
| titel_suche | Phenotypic Characterization of Splenic T Cells from Mice Infected with Plasmodium chabaudi chabaudi |
| topic | WW-YZ |
| uid | nat_lic_papers_NLZ241948916 |