VH-Gene Family Dominance in Ageing Mice
VIALE, A.-C. ; CHIES, J. A. B. ; HUETZ, F. ; MALENCHERE, E. ; WEKSLER, M. ; FREITAS, A. A. ; COUTINHO, A.
Oxford, UK : Blackwell Publishing Ltd
Published 1994
Oxford, UK : Blackwell Publishing Ltd
Published 1994
| ISSN: |
1365-3083
|
|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
|
| Topics: |
Medicine
|
| Notes: |
The cellular composition and Vn-gene family repertoire were compared in different B-cell compartments from young adult (8–12 weeks) and old (18–24 months) C57BL/6 and BALB/c mice. Ageing mice were found to have a higher frequency of peripheral mature B cells utilizing genes from a single VH-gene family. While in each individual old C57BL/6 mice cells expressing the VH J558 gene family consistently were over-represented, a marked individual variation was observed in old BALB/c mice with increased frequency of either the Vh J558, Q52 or J606 families. Aged mice were found also to have a reduced number of bone-marrow pre-B cells and an augmented number of splenic Ig-secreting cells. These results suggest that old mice express less diversified antibody repertoires possibly as a consequence of reduced input from precursors and increased peripheral selection, which may be responsible for the progressive establishment of immunodeficiency.
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798290237206560769 |
|---|---|
| autor | VIALE, A.-C. CHIES, J. A. B. HUETZ, F. MALENCHERE, E. WEKSLER, M. FREITAS, A. A. COUTINHO, A. |
| autorsonst | MALENCHERE, E. WEKSLER, M. FREITAS, A. A. COUTINHO, A. |
| book_url | http://dx.doi.org/10.1111/j.1365-3083.1994.tb03358.x |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLZ241948630 |
| insertion_date | 2012-04-27 |
| issn | 1365-3083 |
| journal_name | Scandinavian journal of immunology |
| materialart | 1 |
| notes | The cellular composition and Vn-gene family repertoire were compared in different B-cell compartments from young adult (8–12 weeks) and old (18–24 months) C57BL/6 and BALB/c mice. Ageing mice were found to have a higher frequency of peripheral mature B cells utilizing genes from a single VH-gene family. While in each individual old C57BL/6 mice cells expressing the VH J558 gene family consistently were over-represented, a marked individual variation was observed in old BALB/c mice with increased frequency of either the Vh J558, Q52 or J606 families. Aged mice were found also to have a reduced number of bone-marrow pre-B cells and an augmented number of splenic Ig-secreting cells. These results suggest that old mice express less diversified antibody repertoires possibly as a consequence of reduced input from precursors and increased peripheral selection, which may be responsible for the progressive establishment of immunodeficiency. |
| package_name | Blackwell Publishing |
| publikationsjahr_anzeige | 1994 |
| publikationsjahr_facette | 1994 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1994 |
| publikationsort | Oxford, UK |
| publisher | Blackwell Publishing Ltd |
| reference | 39 (1994), S. 0 |
| search_space | articles |
| shingle_author_1 | VIALE, A.-C. CHIES, J. A. B. HUETZ, F. MALENCHERE, E. WEKSLER, M. FREITAS, A. A. COUTINHO, A. |
| shingle_author_2 | VIALE, A.-C. CHIES, J. A. B. HUETZ, F. MALENCHERE, E. WEKSLER, M. FREITAS, A. A. COUTINHO, A. |
| shingle_author_3 | VIALE, A.-C. CHIES, J. A. B. HUETZ, F. MALENCHERE, E. WEKSLER, M. FREITAS, A. A. COUTINHO, A. |
| shingle_author_4 | VIALE, A.-C. CHIES, J. A. B. HUETZ, F. MALENCHERE, E. WEKSLER, M. FREITAS, A. A. COUTINHO, A. |
| shingle_catch_all_1 | VIALE, A.-C. CHIES, J. A. B. HUETZ, F. MALENCHERE, E. WEKSLER, M. FREITAS, A. A. COUTINHO, A. VH-Gene Family Dominance in Ageing Mice Blackwell Publishing Ltd The cellular composition and Vn-gene family repertoire were compared in different B-cell compartments from young adult (8–12 weeks) and old (18–24 months) C57BL/6 and BALB/c mice. Ageing mice were found to have a higher frequency of peripheral mature B cells utilizing genes from a single VH-gene family. While in each individual old C57BL/6 mice cells expressing the VH J558 gene family consistently were over-represented, a marked individual variation was observed in old BALB/c mice with increased frequency of either the Vh J558, Q52 or J606 families. Aged mice were found also to have a reduced number of bone-marrow pre-B cells and an augmented number of splenic Ig-secreting cells. These results suggest that old mice express less diversified antibody repertoires possibly as a consequence of reduced input from precursors and increased peripheral selection, which may be responsible for the progressive establishment of immunodeficiency. 1365-3083 13653083 |
| shingle_catch_all_2 | VIALE, A.-C. CHIES, J. A. B. HUETZ, F. MALENCHERE, E. WEKSLER, M. FREITAS, A. A. COUTINHO, A. VH-Gene Family Dominance in Ageing Mice Blackwell Publishing Ltd The cellular composition and Vn-gene family repertoire were compared in different B-cell compartments from young adult (8–12 weeks) and old (18–24 months) C57BL/6 and BALB/c mice. Ageing mice were found to have a higher frequency of peripheral mature B cells utilizing genes from a single VH-gene family. While in each individual old C57BL/6 mice cells expressing the VH J558 gene family consistently were over-represented, a marked individual variation was observed in old BALB/c mice with increased frequency of either the Vh J558, Q52 or J606 families. Aged mice were found also to have a reduced number of bone-marrow pre-B cells and an augmented number of splenic Ig-secreting cells. These results suggest that old mice express less diversified antibody repertoires possibly as a consequence of reduced input from precursors and increased peripheral selection, which may be responsible for the progressive establishment of immunodeficiency. 1365-3083 13653083 |
| shingle_catch_all_3 | VIALE, A.-C. CHIES, J. A. B. HUETZ, F. MALENCHERE, E. WEKSLER, M. FREITAS, A. A. COUTINHO, A. VH-Gene Family Dominance in Ageing Mice Blackwell Publishing Ltd The cellular composition and Vn-gene family repertoire were compared in different B-cell compartments from young adult (8–12 weeks) and old (18–24 months) C57BL/6 and BALB/c mice. Ageing mice were found to have a higher frequency of peripheral mature B cells utilizing genes from a single VH-gene family. While in each individual old C57BL/6 mice cells expressing the VH J558 gene family consistently were over-represented, a marked individual variation was observed in old BALB/c mice with increased frequency of either the Vh J558, Q52 or J606 families. Aged mice were found also to have a reduced number of bone-marrow pre-B cells and an augmented number of splenic Ig-secreting cells. These results suggest that old mice express less diversified antibody repertoires possibly as a consequence of reduced input from precursors and increased peripheral selection, which may be responsible for the progressive establishment of immunodeficiency. 1365-3083 13653083 |
| shingle_catch_all_4 | VIALE, A.-C. CHIES, J. A. B. HUETZ, F. MALENCHERE, E. WEKSLER, M. FREITAS, A. A. COUTINHO, A. VH-Gene Family Dominance in Ageing Mice Blackwell Publishing Ltd The cellular composition and Vn-gene family repertoire were compared in different B-cell compartments from young adult (8–12 weeks) and old (18–24 months) C57BL/6 and BALB/c mice. Ageing mice were found to have a higher frequency of peripheral mature B cells utilizing genes from a single VH-gene family. While in each individual old C57BL/6 mice cells expressing the VH J558 gene family consistently were over-represented, a marked individual variation was observed in old BALB/c mice with increased frequency of either the Vh J558, Q52 or J606 families. Aged mice were found also to have a reduced number of bone-marrow pre-B cells and an augmented number of splenic Ig-secreting cells. These results suggest that old mice express less diversified antibody repertoires possibly as a consequence of reduced input from precursors and increased peripheral selection, which may be responsible for the progressive establishment of immunodeficiency. 1365-3083 13653083 |
| shingle_title_1 | VH-Gene Family Dominance in Ageing Mice |
| shingle_title_2 | VH-Gene Family Dominance in Ageing Mice |
| shingle_title_3 | VH-Gene Family Dominance in Ageing Mice |
| shingle_title_4 | VH-Gene Family Dominance in Ageing Mice |
| sigel_instance_filter | dkfz geomar wilbert ipn albert |
| source_archive | Blackwell Publishing Journal Backfiles 1879-2005 |
| timestamp | 2024-05-06T08:13:30.001Z |
| titel | VH-Gene Family Dominance in Ageing Mice |
| titel_suche | VH-Gene Family Dominance in Ageing Mice |
| topic | WW-YZ |
| uid | nat_lic_papers_NLZ241948630 |