Long-Lasting Immune Response Induced by Recombinant Bacillus Calmette–Guérin (BCG) Secretion System
WADA, N. ; OHARA, N. ; KAMEOKA, M. ; NISHINO, Y. ; MATSUMOTO, S. ; NISHIYAMA, T. ; NAITO, M. ; YUKITAKE, H. ; OKADA, Y. ; IKUTA, K. ; YAMADA, T.
Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
Published 1996
Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
Published 1996
| ISSN: |
1365-3083
|
|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
|
| Topics: |
Medicine
|
| Notes: |
The recombinant bacillus Calmette–Guérin (rBCG) secretion system utilizing an extracellular α antigen of Mycobacterium kansasii (α-K) was characterized biochemically and immunologically. The human immunodeficiency virus type1 (HIV-1) p17gag B cell epitope fused to α-K was secreted in extremely large amounts. At least three mice out of seven inoculated with rBCG generated high titres of antibody to the epitope. The long-lasting antibody production persisted more than 14 months.
|
| Type of Medium: |
Electronic Resource
|
| URL: |