The Effect of Human Chorionic Gonadotropin and Placental Lactogen on Lymphocyte Transformation In Vitro

MORSE, J. H.

Oxford, UK : Blackwell Publishing Ltd
Published 1976
ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Crude preparations of human chorionic gonadotropin (hCG) inhibited phytohemagglutinin (PHA) and allogeneic cell (MLC) lymphocyte stimulation of human peripheral blood lymphocytes (PBL) in vitro as measured by [3H]thymidine incorporation, whereas purified hCG was not inhibitory except at very high concentrations. Sephadex G-100 chromatography of crude hCG showed that the inhibitory effect on PHA lymphocyte stimulation eluted in those fractions after hormonally active hCG. In addition, purified human placental lactogen (hPL) did not inhibit lymphocyte transformation except at very high concentrations. These data suggest that the immunosuppressive activities found in crude preparations arc not due to the hormones but to contaminating material.
Type of Medium:
Electronic Resource
URL: