A Chemical Approach to the Mechanism of B-Lymphocyte Activation

VIDAL-GOMEZ, J. ; HAMMARSTRÖM, L. ; SMITH, C. I. E.

Oxford, UK : Blackwell Publishing Ltd
Published 1978
ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
In an attempt 10 definitively determine whether the pure presentation of haptens (on repetitive, non-metabolizable carriers) to B lymphocytes triggers differentiation to antibody-producing cells, dinitrophenyl and trinitrophenyl groups have been covalently coupled to potentially inert carriers (polymethylmethacrylate, chlorinated polyethylene and cellulose). The resulting conjugates (with three different degrees of hapten substitution) are not immunogenic. It is therefore concluded that the pure presentation of haptens to B lymphocytes docs not trigger antibody formation.
Type of Medium:
Electronic Resource
URL: