Detection of Antibodies in Human Sera to Streptococcal Groups A and C Carbohydrates by a Radioimmunoassay
AASTED, B. ; BERNSTEIN, D. ; KLAPPER, D. G. ; KHOLY, A. ; KRAUSE, R. M.
Oxford, UK : Blackwell Publishing Ltd
Published 1979
Oxford, UK : Blackwell Publishing Ltd
Published 1979
| ISSN: |
1365-3083
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| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
Human antibodies to Streptococcal groups A and C carbohydrates were measured quantitatively with a radioimmunoassay using tyrosylated 125I carbohydrate. Analysis of acute and convalescent sera from people with groups A or C streptococcal pharyngeal infection or persistent carriage revealed a significant rise in antibodies. Inhibition reactions with the cold carbohydrate indicated the specificity of the elicited antibodies. In some instances, group C as well as group A antibodies occurred after group A pharyngeal infections. Further clinical and epidemiological studies are required to determine the significance of group-specific antibodies. Antistreptolysin-O (ASO) rises were observed in individuals with group C antibody responses after persistent group C pharyngeal carriage. For this reason, epidemiological surveys that rely primarily on ASO surveys to determine the incidence of group A streptococcal infections must be interpreted wilh caution, at least in the developing countries, where group C pharyngeal carriage is common.
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| Type of Medium: |
Electronic Resource
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| URL: |