THE COMPARATIVE EFFECTS OF VARIOUS HYDRA-ZIDES ON γ-AMINOBUTYRIC ACID AND ITS METABOLISM

1471-4159

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Abstract— The administration of different hydrazides to chicks (20-23 days post-hatching) in amounts giving similar latent periods before the onset of seizures produced (i) similar rates of decrease in content of cerebral GABA, (ii) considerable but dissimilar inhibitions of cerebral GAD activity, (iii) slight inhibitions of cerebral GABA-T activity. The results support the view that low GABA levels were involved in. the etiology of the seizures but seemed to rule out the possibility that a reduced turnover of GABA was responsible for the occurrence of the convulsions.

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