Effects of Chronic Ethanol Administration on Rat Brain Phospholipid Metabolism
Sun, Grace Y. ; Huang, Hsueh-Meei ; Chandrasekhar, Renuka ; Lee, Ding Z. ; Sun, Albert Y.
Oxford, UK : Blackwell Publishing Ltd
Published 1987
Oxford, UK : Blackwell Publishing Ltd
Published 1987
| ISSN: |
1471-4159
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|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
Abstract: Alterations in brain phospholipid metabolism were observed after chronic ethanol administration for 16 days to developing rats. Animals were injected intraperitoneally with 32Pi 16 h prior to killing. Overall uptake of 32Pi by brain did not differ between the control and ethanol-treated groups, which were killed 2 h and 24 h after the last ethanol feeding. Except for an increase in the labeling of myelin after ethanoi treatment, the amount of radioactivity recovered in the synaptosomal-mitochondrial and plasma membrane fractions of control and ethanol-treated groups was not different. Relative to the radioactivity of phosphatidylcholines, which indicated no change, there were increases (20–44%) in labeling of ethanolamine plasmalogens, phosphatidic acids, and phosphatidylinositols in cortical synaptosomes from the 2-h ethanol-treated group. In the plasma membrane fractions, however, increases (9–14%) in labeling of phosphatidylserines and phosphatidylinositols were observed in both 2- and 24-h ethanol-treated groups. In both membrane fractions, there was an obvious increase (44–86%) in labeling of polyphosphoinositides at 24 h after withdrawal from ethanol. Results thus indicate an adaptive increase in the biosynthesis of ethanolamine plasmalogen and brain acidic phospholipids due to chronic ethanol administration. Furthermore, the increase in labeling of polyphosphoinositides in the 24-h withdrawal group may reflect the hypoactivity associated with ethanol withdrawal.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798289990295224320 |
|---|---|
| autor | Sun, Grace Y. Huang, Hsueh-Meei Chandrasekhar, Renuka Lee, Ding Z. Sun, Albert Y. |
| autorsonst | Lee, Ding Z. Sun, Albert Y. |
| book_url | http://dx.doi.org/10.1111/j.1471-4159.1987.tb05612.x |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLZ240289153 |
| insertion_date | 2012-04-26 |
| issn | 1471-4159 |
| journal_name | Journal of neurochemistry |
| materialart | 1 |
| notes | Abstract: Alterations in brain phospholipid metabolism were observed after chronic ethanol administration for 16 days to developing rats. Animals were injected intraperitoneally with 32Pi 16 h prior to killing. Overall uptake of 32Pi by brain did not differ between the control and ethanol-treated groups, which were killed 2 h and 24 h after the last ethanol feeding. Except for an increase in the labeling of myelin after ethanoi treatment, the amount of radioactivity recovered in the synaptosomal-mitochondrial and plasma membrane fractions of control and ethanol-treated groups was not different. Relative to the radioactivity of phosphatidylcholines, which indicated no change, there were increases (20–44%) in labeling of ethanolamine plasmalogens, phosphatidic acids, and phosphatidylinositols in cortical synaptosomes from the 2-h ethanol-treated group. In the plasma membrane fractions, however, increases (9–14%) in labeling of phosphatidylserines and phosphatidylinositols were observed in both 2- and 24-h ethanol-treated groups. In both membrane fractions, there was an obvious increase (44–86%) in labeling of polyphosphoinositides at 24 h after withdrawal from ethanol. Results thus indicate an adaptive increase in the biosynthesis of ethanolamine plasmalogen and brain acidic phospholipids due to chronic ethanol administration. Furthermore, the increase in labeling of polyphosphoinositides in the 24-h withdrawal group may reflect the hypoactivity associated with ethanol withdrawal. |
| package_name | Blackwell Publishing |
| publikationsjahr_anzeige | 1987 |
| publikationsjahr_facette | 1987 |
| publikationsjahr_intervall | 8014:1985-1989 |
| publikationsjahr_sort | 1987 |
| publikationsort | Oxford, UK |
| publisher | Blackwell Publishing Ltd |
| reference | 48 (1987), S. 0 |
| search_space | articles |
| shingle_author_1 | Sun, Grace Y. Huang, Hsueh-Meei Chandrasekhar, Renuka Lee, Ding Z. Sun, Albert Y. |
| shingle_author_2 | Sun, Grace Y. Huang, Hsueh-Meei Chandrasekhar, Renuka Lee, Ding Z. Sun, Albert Y. |
| shingle_author_3 | Sun, Grace Y. Huang, Hsueh-Meei Chandrasekhar, Renuka Lee, Ding Z. Sun, Albert Y. |
| shingle_author_4 | Sun, Grace Y. Huang, Hsueh-Meei Chandrasekhar, Renuka Lee, Ding Z. Sun, Albert Y. |
| shingle_catch_all_1 | Sun, Grace Y. Huang, Hsueh-Meei Chandrasekhar, Renuka Lee, Ding Z. Sun, Albert Y. Effects of Chronic Ethanol Administration on Rat Brain Phospholipid Metabolism Blackwell Publishing Ltd Abstract: Alterations in brain phospholipid metabolism were observed after chronic ethanol administration for 16 days to developing rats. Animals were injected intraperitoneally with 32Pi 16 h prior to killing. Overall uptake of 32Pi by brain did not differ between the control and ethanol-treated groups, which were killed 2 h and 24 h after the last ethanol feeding. Except for an increase in the labeling of myelin after ethanoi treatment, the amount of radioactivity recovered in the synaptosomal-mitochondrial and plasma membrane fractions of control and ethanol-treated groups was not different. Relative to the radioactivity of phosphatidylcholines, which indicated no change, there were increases (20–44%) in labeling of ethanolamine plasmalogens, phosphatidic acids, and phosphatidylinositols in cortical synaptosomes from the 2-h ethanol-treated group. In the plasma membrane fractions, however, increases (9–14%) in labeling of phosphatidylserines and phosphatidylinositols were observed in both 2- and 24-h ethanol-treated groups. In both membrane fractions, there was an obvious increase (44–86%) in labeling of polyphosphoinositides at 24 h after withdrawal from ethanol. Results thus indicate an adaptive increase in the biosynthesis of ethanolamine plasmalogen and brain acidic phospholipids due to chronic ethanol administration. Furthermore, the increase in labeling of polyphosphoinositides in the 24-h withdrawal group may reflect the hypoactivity associated with ethanol withdrawal. 1471-4159 14714159 |
| shingle_catch_all_2 | Sun, Grace Y. Huang, Hsueh-Meei Chandrasekhar, Renuka Lee, Ding Z. Sun, Albert Y. Effects of Chronic Ethanol Administration on Rat Brain Phospholipid Metabolism Blackwell Publishing Ltd Abstract: Alterations in brain phospholipid metabolism were observed after chronic ethanol administration for 16 days to developing rats. Animals were injected intraperitoneally with 32Pi 16 h prior to killing. Overall uptake of 32Pi by brain did not differ between the control and ethanol-treated groups, which were killed 2 h and 24 h after the last ethanol feeding. Except for an increase in the labeling of myelin after ethanoi treatment, the amount of radioactivity recovered in the synaptosomal-mitochondrial and plasma membrane fractions of control and ethanol-treated groups was not different. Relative to the radioactivity of phosphatidylcholines, which indicated no change, there were increases (20–44%) in labeling of ethanolamine plasmalogens, phosphatidic acids, and phosphatidylinositols in cortical synaptosomes from the 2-h ethanol-treated group. In the plasma membrane fractions, however, increases (9–14%) in labeling of phosphatidylserines and phosphatidylinositols were observed in both 2- and 24-h ethanol-treated groups. In both membrane fractions, there was an obvious increase (44–86%) in labeling of polyphosphoinositides at 24 h after withdrawal from ethanol. Results thus indicate an adaptive increase in the biosynthesis of ethanolamine plasmalogen and brain acidic phospholipids due to chronic ethanol administration. Furthermore, the increase in labeling of polyphosphoinositides in the 24-h withdrawal group may reflect the hypoactivity associated with ethanol withdrawal. 1471-4159 14714159 |
| shingle_catch_all_3 | Sun, Grace Y. Huang, Hsueh-Meei Chandrasekhar, Renuka Lee, Ding Z. Sun, Albert Y. Effects of Chronic Ethanol Administration on Rat Brain Phospholipid Metabolism Blackwell Publishing Ltd Abstract: Alterations in brain phospholipid metabolism were observed after chronic ethanol administration for 16 days to developing rats. Animals were injected intraperitoneally with 32Pi 16 h prior to killing. Overall uptake of 32Pi by brain did not differ between the control and ethanol-treated groups, which were killed 2 h and 24 h after the last ethanol feeding. Except for an increase in the labeling of myelin after ethanoi treatment, the amount of radioactivity recovered in the synaptosomal-mitochondrial and plasma membrane fractions of control and ethanol-treated groups was not different. Relative to the radioactivity of phosphatidylcholines, which indicated no change, there were increases (20–44%) in labeling of ethanolamine plasmalogens, phosphatidic acids, and phosphatidylinositols in cortical synaptosomes from the 2-h ethanol-treated group. In the plasma membrane fractions, however, increases (9–14%) in labeling of phosphatidylserines and phosphatidylinositols were observed in both 2- and 24-h ethanol-treated groups. In both membrane fractions, there was an obvious increase (44–86%) in labeling of polyphosphoinositides at 24 h after withdrawal from ethanol. Results thus indicate an adaptive increase in the biosynthesis of ethanolamine plasmalogen and brain acidic phospholipids due to chronic ethanol administration. Furthermore, the increase in labeling of polyphosphoinositides in the 24-h withdrawal group may reflect the hypoactivity associated with ethanol withdrawal. 1471-4159 14714159 |
| shingle_catch_all_4 | Sun, Grace Y. Huang, Hsueh-Meei Chandrasekhar, Renuka Lee, Ding Z. Sun, Albert Y. Effects of Chronic Ethanol Administration on Rat Brain Phospholipid Metabolism Blackwell Publishing Ltd Abstract: Alterations in brain phospholipid metabolism were observed after chronic ethanol administration for 16 days to developing rats. Animals were injected intraperitoneally with 32Pi 16 h prior to killing. Overall uptake of 32Pi by brain did not differ between the control and ethanol-treated groups, which were killed 2 h and 24 h after the last ethanol feeding. Except for an increase in the labeling of myelin after ethanoi treatment, the amount of radioactivity recovered in the synaptosomal-mitochondrial and plasma membrane fractions of control and ethanol-treated groups was not different. Relative to the radioactivity of phosphatidylcholines, which indicated no change, there were increases (20–44%) in labeling of ethanolamine plasmalogens, phosphatidic acids, and phosphatidylinositols in cortical synaptosomes from the 2-h ethanol-treated group. In the plasma membrane fractions, however, increases (9–14%) in labeling of phosphatidylserines and phosphatidylinositols were observed in both 2- and 24-h ethanol-treated groups. In both membrane fractions, there was an obvious increase (44–86%) in labeling of polyphosphoinositides at 24 h after withdrawal from ethanol. Results thus indicate an adaptive increase in the biosynthesis of ethanolamine plasmalogen and brain acidic phospholipids due to chronic ethanol administration. Furthermore, the increase in labeling of polyphosphoinositides in the 24-h withdrawal group may reflect the hypoactivity associated with ethanol withdrawal. 1471-4159 14714159 |
| shingle_title_1 | Effects of Chronic Ethanol Administration on Rat Brain Phospholipid Metabolism |
| shingle_title_2 | Effects of Chronic Ethanol Administration on Rat Brain Phospholipid Metabolism |
| shingle_title_3 | Effects of Chronic Ethanol Administration on Rat Brain Phospholipid Metabolism |
| shingle_title_4 | Effects of Chronic Ethanol Administration on Rat Brain Phospholipid Metabolism |
| sigel_instance_filter | dkfz geomar wilbert ipn albert |
| source_archive | Blackwell Publishing Journal Backfiles 1879-2005 |
| timestamp | 2024-05-06T08:09:36.926Z |
| titel | Effects of Chronic Ethanol Administration on Rat Brain Phospholipid Metabolism |
| titel_suche | Effects of Chronic Ethanol Administration on Rat Brain Phospholipid Metabolism |
| topic | WW-YZ |
| uid | nat_lic_papers_NLZ240289153 |