The in vivo fractional rate of gingival collagen production in non-diabetic and diabetic rats
Schntir, M. ; Imberman, M. ; Ramamurtiiy, N. ; Golub, L.
Oxford, UK : Blackwell Publishing Ltd
Published 1986
Oxford, UK : Blackwell Publishing Ltd
Published 1986
| ISSN: |
1600-0765
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| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
A new approach (pool-expansion) has been applied for quantifying the in vivo fractional rate of gingival collagen production. This approach obviates a major shortcoming inherent in a lraditional tracer approach; decreasing specific radioactivity S. R., DPM/μg proline of tissue free-Phlproline oocurring throughout the interval during stuch production is meausured, Poolexparision, involving the injection of excess unlaheled proline concomitant with a tracer amount of nidiotabeled proline, has been judged successful for incisor gingiva of non-diabetic control rats by the following enteria. (I) the S. R. of gingival tree-PHlproline remained constant from 0.5 to 2 h after Phlproline anjection and (2) during this interval, radiolabeled collagen Phlhydroxyprobne S. R. inereised linearly in contrasl pool-expansion in gingiva of diabetic rats was less successful 0.5 h after injection, the S. R. of gingival free S. R. of gingival freep-Phlproline was less than that after 2 h. indicating incomplete pool-expansion at 0.5 h.For meisor gingiva of non-diabetic control rats, the fractronal rate of collagen production 1–1% a day is slouer than that in rat skin, For incisor gingiva of diaberic rats, the fractronat rate in reduced by 65%
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| Type of Medium: |
Electronic Resource
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| URL: |